Comparação da prevalência de comorbidades em pacientes com Arterite de Takayasu e Arterite de células gigantes

• Autor(a) principal: Ferreira, Cristiane Janson
• Data de Publicação: 2017
• Tipo de documento: Trabalho de conclusão de curso
• Idioma: por
• Título da fonte: Repositório Universitário da Ânima (RUNA)
• Texto Completo: https://repositorio.animaeducacao.com.br/handle/ANIMA/9252
• topic: Arterite de Takayasu; Arterite de células gigantes; Dislipidemias; Diabetes Mellitus; Hipertensão Arterial Sistêmica; Comorbidade

Introduction: Vasculitis are associated with high morbi-mortality caused by cardiovascular disease, through accelerated atherosclerosis. This process has a multifactorial risk factors, which could be related to aspects of the inflammatory disease itself, to the use of steroids and to the presence of traditional risk factors of cardiovascular diseases. Objective: Analyze if patients with large vessels vasculitis (LVV) have higher frequency of comorbidities and compare the prevalence between Takayasu arteritis (TAA) and giant cell arteritis (GCA). Method: 45 medical records of patients who had LVV were analyzed in a retrospective study in Florianopolis, Brazil. Demographic data were collected, as well as related to clinical tidings. These data were compared between the vasculitis groups (TAA and GCA) through analysis on SPSS 18.0, t-student test and chi-squared test or Fisher’s exact test, p ≤ 0,05. Project was approved by Human Research Ethics Committee of the related institutions. Results: Among the 45 patients, 22 had TAA and 23 had GCA. 84,4% of the patients were women. The percentage of systemic arterial hypertension, diabetes mellitus and dyslipidemia on TAA were 77,3%, 9,1% and 95,5%, respectively. In the same order these comorbidities were found in GCA patients in 87%, 39,1% and 100%. The control of dyslipidemia was not satisfactory in both groups. Lipid profile did not have a significant difference between TAA and GCA. Conclusion: Patients with GCA have higher prevalence of diabetes mellitus when compared to general population and to TAA. The higher prevalence of systemic arterial hypertension and dyslipidemia found in LVV combined with endothelial inflammation due to vasculitis can contribute to accelerate atherosclerosis and should be evaluated and well treated.