Avaliação histológica de neoplasias mamárias induzidas por DMBA em camundongos SWISS sujeitos à dieta hiperlipídica e tratados com inibidor de COX-2

• Autor(a) principal: Vieira, Thaynan Cunha
• Data de Publicação: 2019
• Tipo de documento: Trabalho de conclusão de curso
• Idioma: por
• Título da fonte: Repositório Universitário da Ânima (RUNA)
• Texto Completo: https://repositorio.animaeducacao.com.br/handle/ANIMA/12725
• topic: Câncer de mama; Classificação histológica; Camundongos; Inflamação

The present study has as objective to report through a scientific article the comparison of two references to classify DMBA-induced breast tumors in female Swiss mice, as well as to evaluate and correlate the tissue inflammation in these tumors of mice subjected to a high fat diet (DH) and treatment with etoricoxib. In this work, breast cancer and animal models were reviewed, as well as the role of the lipid-rich diet and tissue inflammation in the neoplastic context. 52 tumors induced by DMBA in mice were histologically classified. Subsequently, only those of mammary origin were analyzed for inflammatory infiltrate and angiogenesis. 22/52 (42.31%) tumors of mammary origin were observed. From these, it was possible to classify 2 histological types according to Sass and Dunn, whereas according to Cassali, 7 types were obtained, and Adenoacantoma and Micropapillary Carcinoma were the most frequent type, respectively. Among the carcinomas, there were 3 more aggressive types, present significantly more frequently in the DH groups, and there was no difference in the group treated with etoricoxib. Likewise, there was a slight increase in the intensity of inflammatory infiltrate and number of blood vessels in the DH groups. Therefore, it is concluded that DMBA did not induce mammary tumors in the majority, and the histological classification of Cassali was more detailed. Although treatment with Etoricoxib did not decrease inflammation, the DH was able to induce a greater degree of tumor malignancy.