Association between the use of magnesium sulfate as neuroprotector in prematurity and the neonatal hemodynamic effects

• Autor(a) principal: Nunes, Rodrigo Dias
• Data de Publicação: 2017
• Outros Autores: Schutz, Flávia Duarte, Traebert, Jefferson
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Universitário da Ânima (RUNA)
• Texto Completo: http://www.tandfonline.com/doi/full/10.1080/14767058.2017.1332033; https://repositorio.animaeducacao.com.br/handle/ANIMA/2623
• topic: Magnesium sulfate; Hemodynamics; Infant; Premature; Neuroprotection; Fetal outcome

Purpose: Cerebral palsy is often associated with prematurity and magnesium sulfate (MgSO4) has been used as a neuroprotector, with favorable results. However, its mechanism of action has not been fully elucidated. This study aimed to evaluate the association between MgSO4 at the imminent premature delivery and neonatal hemodynamic effects. Materials and methods: A cross-sectional study involving 94 newborns (NB) between 24 and 32weeks at a Brazilian hospital was performed. Bivariate analysis between the use or the non- use of MgSO4 and hemodynamic characteristics was performed, using the Chi-square test. Results: NB were evaluated between those who received MgSO4 (27.7) and those who did not (72.3%). Normal heart rate was verified in 62.8% of NB, normal respiratory rate in 70.2%, and nor- mal temperature in 22.3%. Oxygen saturation higher or equal than 95% was evidenced in 85.1% of NB, normal hemoglucotest in 74.5%, and hemoglobin greater or equal than 16.4g/dL in 30.9%. Non-invasive ventilation was performed in 48.9% of NB, while 51.1% were submitted to endotracheal ventilation. There was no significance relation detected between the use of MgSO4 and the hemodynamic characteristics. Conclusions: MgSO4 does not appear to influence hemodynamic factors as a cause of the neu- roprotection in premature NB.