Antimutagenic and antirecombinagenic activities of noni fruit juice in somatic cells of Drosophila melanogaster

• Autor(a) principal: FRANCHI,LEONARDO P.
• Data de Publicação: 2013
• Outros Autores: GUIMARAES,NILZA N., ANDRADE,LAISE R. DE, ANDRADE,HELOISA H.R. DE, LEHMANN,MAURICIO, DIHL,RAFAEL R., CUNHA,KENYA S.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Anais da Academia Brasileira de Ciências (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652013000200585
• topic: antigenotoxicity; doxorrubicin; mitomycin C; SMART; noni juice

Noni, a Hawaiian name for the fruit of Morinda citrifolia L., is a traditional medicinal plant from Polynesia widely used for the treatment of many diseases including arthritis, diabetes, asthma, hypertension and cancer. Here, a commercial noni juice (TNJ) was evaluated for its protective activities against the lesions induced by mitomycin C (MMC) and doxorrubicin (DXR) using the Somatic Mutation and Recombination Test (SMART) in Drosophila melanogaster. Three-day-old larvae, trans-heterozygous for two genetic markers (mwh and flr3 ), were co-treated with TNJ plus MMC or DXR. We have observed a reduction in genotoxic effects of MMC and DXR caused by the juice. TNJ provoked a marked decrease in all kinds of MMC- and DXR-induced mutant spots, mainly due to its antirecombinagenic activity. The TNJ protective effects were concentration-dependent, indicating a dose-response correlation, that can be attributed to a powerful antioxidant and/or free radical scavenger ability of TNJ.