Novel insights in bacterial vaginosis etiology through genomic approaches

Detalhes bibliográficos
Autor(a) principal: ALMEIDA,MARCELLE O.
Data de Publicação: 2021
Outros Autores: VIANA,MARCUS V.C., CERQUEIRA,JANAÍNA C., ABURJAILE,FLAVIA F., JUNIOR,ANDREY A.Z., AZEVEDO,VASCO, CARVALHO,RODRIGO D.O.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Anais da Academia Brasileira de Ciências (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652021000300901
Resumo: Abstract Bacterial vaginosis (BV) has been considered as dysbiosis state whose etiology is not fully understood. This condition affects a large number of women of reproductive age and its study has been highly relevant due to the growing association of BV with and gynecological and obstetric complications and diseases, in addition to a greater susceptibility to sexually transmitted diseases, including HIV. The vaginal microbiota composition presents high variability among different ethnic groups of women, although, generally, the prevalence of lactobacilli species has been reported. Several studies suggest they may play a protective role, especially Lactobacillus crispatus whose population is typically present in low proportions in women with BV. This review article describes the contributions and limitations of genomic approaches in elucidating protective characteristics and mechanisms associated with colonization and persistence of lactobacilli strains. Although some genetic features were associated with resilience of L. crispatus during BV, furher studies are required to uncover their functions.
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spelling Novel insights in bacterial vaginosis etiology through genomic approachesbacterial vaginosisgenomicshealthLactobacillusAbstract Bacterial vaginosis (BV) has been considered as dysbiosis state whose etiology is not fully understood. This condition affects a large number of women of reproductive age and its study has been highly relevant due to the growing association of BV with and gynecological and obstetric complications and diseases, in addition to a greater susceptibility to sexually transmitted diseases, including HIV. The vaginal microbiota composition presents high variability among different ethnic groups of women, although, generally, the prevalence of lactobacilli species has been reported. Several studies suggest they may play a protective role, especially Lactobacillus crispatus whose population is typically present in low proportions in women with BV. This review article describes the contributions and limitations of genomic approaches in elucidating protective characteristics and mechanisms associated with colonization and persistence of lactobacilli strains. Although some genetic features were associated with resilience of L. crispatus during BV, furher studies are required to uncover their functions.Academia Brasileira de Ciências2021-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652021000300901Anais da Academia Brasileira de Ciências v.93 n.2 2021reponame:Anais da Academia Brasileira de Ciências (Online)instname:Academia Brasileira de Ciências (ABC)instacron:ABC10.1590/0001-3765202120200945info:eu-repo/semantics/openAccessALMEIDA,MARCELLE O.VIANA,MARCUS V.C.CERQUEIRA,JANAÍNA C.ABURJAILE,FLAVIA F.JUNIOR,ANDREY A.Z.AZEVEDO,VASCOCARVALHO,RODRIGO D.O.eng2021-03-04T00:00:00Zoai:scielo:S0001-37652021000300901Revistahttp://www.scielo.br/aabchttps://old.scielo.br/oai/scielo-oai.php||aabc@abc.org.br1678-26900001-3765opendoar:2021-03-04T00:00Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC)false
dc.title.none.fl_str_mv Novel insights in bacterial vaginosis etiology through genomic approaches
title Novel insights in bacterial vaginosis etiology through genomic approaches
spellingShingle Novel insights in bacterial vaginosis etiology through genomic approaches
ALMEIDA,MARCELLE O.
bacterial vaginosis
genomics
health
Lactobacillus
title_short Novel insights in bacterial vaginosis etiology through genomic approaches
title_full Novel insights in bacterial vaginosis etiology through genomic approaches
title_fullStr Novel insights in bacterial vaginosis etiology through genomic approaches
title_full_unstemmed Novel insights in bacterial vaginosis etiology through genomic approaches
title_sort Novel insights in bacterial vaginosis etiology through genomic approaches
author ALMEIDA,MARCELLE O.
author_facet ALMEIDA,MARCELLE O.
VIANA,MARCUS V.C.
CERQUEIRA,JANAÍNA C.
ABURJAILE,FLAVIA F.
JUNIOR,ANDREY A.Z.
AZEVEDO,VASCO
CARVALHO,RODRIGO D.O.
author_role author
author2 VIANA,MARCUS V.C.
CERQUEIRA,JANAÍNA C.
ABURJAILE,FLAVIA F.
JUNIOR,ANDREY A.Z.
AZEVEDO,VASCO
CARVALHO,RODRIGO D.O.
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv ALMEIDA,MARCELLE O.
VIANA,MARCUS V.C.
CERQUEIRA,JANAÍNA C.
ABURJAILE,FLAVIA F.
JUNIOR,ANDREY A.Z.
AZEVEDO,VASCO
CARVALHO,RODRIGO D.O.
dc.subject.por.fl_str_mv bacterial vaginosis
genomics
health
Lactobacillus
topic bacterial vaginosis
genomics
health
Lactobacillus
description Abstract Bacterial vaginosis (BV) has been considered as dysbiosis state whose etiology is not fully understood. This condition affects a large number of women of reproductive age and its study has been highly relevant due to the growing association of BV with and gynecological and obstetric complications and diseases, in addition to a greater susceptibility to sexually transmitted diseases, including HIV. The vaginal microbiota composition presents high variability among different ethnic groups of women, although, generally, the prevalence of lactobacilli species has been reported. Several studies suggest they may play a protective role, especially Lactobacillus crispatus whose population is typically present in low proportions in women with BV. This review article describes the contributions and limitations of genomic approaches in elucidating protective characteristics and mechanisms associated with colonization and persistence of lactobacilli strains. Although some genetic features were associated with resilience of L. crispatus during BV, furher studies are required to uncover their functions.
publishDate 2021
dc.date.none.fl_str_mv 2021-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652021000300901
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652021000300901
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0001-3765202120200945
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Ciências
publisher.none.fl_str_mv Academia Brasileira de Ciências
dc.source.none.fl_str_mv Anais da Academia Brasileira de Ciências v.93 n.2 2021
reponame:Anais da Academia Brasileira de Ciências (Online)
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reponame_str Anais da Academia Brasileira de Ciências (Online)
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repository.name.fl_str_mv Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC)
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