Relationship between testicular lesion and hormone levels in male rats infected with Trypanosoma evansi
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Anais da Academia Brasileira de Ciências (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652014000301537 |
Resumo: | The aim of this study was to evaluate the relationship between testicular lesions and hormone levels in rats experimentally infected with Trypanosoma evansi. For that, the measurement of reproductive hormones, histopathology and biomarkers of cellular injury were carried out in twenty-four animals, which were divided into two groups with 12 animals each. Group A was the negative control, or uninfected, while group B was composed by animals infected with T. evansi. Both groups were divided again into two other subgroups (n=6), from which serum and testicular fragments were collected on days 5 (A1 and B1) and 15 (A2 and B2) post-infection (PI). The morphological analysis showed increased alterations of head and tail of sperm in infected rats when compared with those of the control group. A significant reduction (P<0.01) in the levels of LH, FSH, testosterone and estradiol, associated with an increase in cortisol, was observed in serum of group B when compared with negative control. Additionally, NOx, lipid peroxidation and protein oxidation were enhanced in testicles, indicating the occurrence of cellular lesion. On histopathology, it was possible to observe testicular degeneration, among other disorders in infected animals. Therefore, based on these results, it is possible to conclude that the experimental infection with T. evansi caused changes in the levels of the main hormones of male rats associated with cellular injury. |
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Relationship between testicular lesion and hormone levels in male rats infected with Trypanosoma evansiprotozoaWistar ratstesticular lesionreproductionoxidative stressThe aim of this study was to evaluate the relationship between testicular lesions and hormone levels in rats experimentally infected with Trypanosoma evansi. For that, the measurement of reproductive hormones, histopathology and biomarkers of cellular injury were carried out in twenty-four animals, which were divided into two groups with 12 animals each. Group A was the negative control, or uninfected, while group B was composed by animals infected with T. evansi. Both groups were divided again into two other subgroups (n=6), from which serum and testicular fragments were collected on days 5 (A1 and B1) and 15 (A2 and B2) post-infection (PI). The morphological analysis showed increased alterations of head and tail of sperm in infected rats when compared with those of the control group. A significant reduction (P<0.01) in the levels of LH, FSH, testosterone and estradiol, associated with an increase in cortisol, was observed in serum of group B when compared with negative control. Additionally, NOx, lipid peroxidation and protein oxidation were enhanced in testicles, indicating the occurrence of cellular lesion. On histopathology, it was possible to observe testicular degeneration, among other disorders in infected animals. Therefore, based on these results, it is possible to conclude that the experimental infection with T. evansi caused changes in the levels of the main hormones of male rats associated with cellular injury.Academia Brasileira de Ciências2014-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652014000301537Anais da Academia Brasileira de Ciências v.86 n.3 2014reponame:Anais da Academia Brasileira de Ciências (Online)instname:Academia Brasileira de Ciências (ABC)instacron:ABC10.1590/0001-3765201420130167info:eu-repo/semantics/openAccessFACCIO,LUCIANASILVA,ALEKSANDRO S. DATONIN,ALEXANDRE A.OBERHERR,LUCASGRESSLER,LUCAS T.OLIVEIRA,CAMILA B.OLIVEIRA,DIONATAN T.SANGOI,MANUELA B.MORESCO,RAFAEL N.SAMARA,YASMIN N.VEIGA,MARCELODUARTE,MARTA M.M.F.MONTEIRO,SILVIA G.eng2015-05-07T00:00:00Zoai:scielo:S0001-37652014000301537Revistahttp://www.scielo.br/aabchttps://old.scielo.br/oai/scielo-oai.php||aabc@abc.org.br1678-26900001-3765opendoar:2015-05-07T00:00Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC)false |
dc.title.none.fl_str_mv |
Relationship between testicular lesion and hormone levels in male rats infected with Trypanosoma evansi |
title |
Relationship between testicular lesion and hormone levels in male rats infected with Trypanosoma evansi |
spellingShingle |
Relationship between testicular lesion and hormone levels in male rats infected with Trypanosoma evansi FACCIO,LUCIANA protozoa Wistar rats testicular lesion reproduction oxidative stress |
title_short |
Relationship between testicular lesion and hormone levels in male rats infected with Trypanosoma evansi |
title_full |
Relationship between testicular lesion and hormone levels in male rats infected with Trypanosoma evansi |
title_fullStr |
Relationship between testicular lesion and hormone levels in male rats infected with Trypanosoma evansi |
title_full_unstemmed |
Relationship between testicular lesion and hormone levels in male rats infected with Trypanosoma evansi |
title_sort |
Relationship between testicular lesion and hormone levels in male rats infected with Trypanosoma evansi |
author |
FACCIO,LUCIANA |
author_facet |
FACCIO,LUCIANA SILVA,ALEKSANDRO S. DA TONIN,ALEXANDRE A. OBERHERR,LUCAS GRESSLER,LUCAS T. OLIVEIRA,CAMILA B. OLIVEIRA,DIONATAN T. SANGOI,MANUELA B. MORESCO,RAFAEL N. SAMARA,YASMIN N. VEIGA,MARCELO DUARTE,MARTA M.M.F. MONTEIRO,SILVIA G. |
author_role |
author |
author2 |
SILVA,ALEKSANDRO S. DA TONIN,ALEXANDRE A. OBERHERR,LUCAS GRESSLER,LUCAS T. OLIVEIRA,CAMILA B. OLIVEIRA,DIONATAN T. SANGOI,MANUELA B. MORESCO,RAFAEL N. SAMARA,YASMIN N. VEIGA,MARCELO DUARTE,MARTA M.M.F. MONTEIRO,SILVIA G. |
author2_role |
author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
FACCIO,LUCIANA SILVA,ALEKSANDRO S. DA TONIN,ALEXANDRE A. OBERHERR,LUCAS GRESSLER,LUCAS T. OLIVEIRA,CAMILA B. OLIVEIRA,DIONATAN T. SANGOI,MANUELA B. MORESCO,RAFAEL N. SAMARA,YASMIN N. VEIGA,MARCELO DUARTE,MARTA M.M.F. MONTEIRO,SILVIA G. |
dc.subject.por.fl_str_mv |
protozoa Wistar rats testicular lesion reproduction oxidative stress |
topic |
protozoa Wistar rats testicular lesion reproduction oxidative stress |
description |
The aim of this study was to evaluate the relationship between testicular lesions and hormone levels in rats experimentally infected with Trypanosoma evansi. For that, the measurement of reproductive hormones, histopathology and biomarkers of cellular injury were carried out in twenty-four animals, which were divided into two groups with 12 animals each. Group A was the negative control, or uninfected, while group B was composed by animals infected with T. evansi. Both groups were divided again into two other subgroups (n=6), from which serum and testicular fragments were collected on days 5 (A1 and B1) and 15 (A2 and B2) post-infection (PI). The morphological analysis showed increased alterations of head and tail of sperm in infected rats when compared with those of the control group. A significant reduction (P<0.01) in the levels of LH, FSH, testosterone and estradiol, associated with an increase in cortisol, was observed in serum of group B when compared with negative control. Additionally, NOx, lipid peroxidation and protein oxidation were enhanced in testicles, indicating the occurrence of cellular lesion. On histopathology, it was possible to observe testicular degeneration, among other disorders in infected animals. Therefore, based on these results, it is possible to conclude that the experimental infection with T. evansi caused changes in the levels of the main hormones of male rats associated with cellular injury. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-09-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652014000301537 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652014000301537 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/0001-3765201420130167 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Ciências |
publisher.none.fl_str_mv |
Academia Brasileira de Ciências |
dc.source.none.fl_str_mv |
Anais da Academia Brasileira de Ciências v.86 n.3 2014 reponame:Anais da Academia Brasileira de Ciências (Online) instname:Academia Brasileira de Ciências (ABC) instacron:ABC |
instname_str |
Academia Brasileira de Ciências (ABC) |
instacron_str |
ABC |
institution |
ABC |
reponame_str |
Anais da Academia Brasileira de Ciências (Online) |
collection |
Anais da Academia Brasileira de Ciências (Online) |
repository.name.fl_str_mv |
Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC) |
repository.mail.fl_str_mv |
||aabc@abc.org.br |
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1754302860321882112 |