Relationship between testicular lesion and hormone levels in male rats infected with Trypanosoma evansi

Detalhes bibliográficos
Autor(a) principal: FACCIO,LUCIANA
Data de Publicação: 2014
Outros Autores: SILVA,ALEKSANDRO S. DA, TONIN,ALEXANDRE A., OBERHERR,LUCAS, GRESSLER,LUCAS T., OLIVEIRA,CAMILA B., OLIVEIRA,DIONATAN T., SANGOI,MANUELA B., MORESCO,RAFAEL N., SAMARA,YASMIN N., VEIGA,MARCELO, DUARTE,MARTA M.M.F., MONTEIRO,SILVIA G.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Anais da Academia Brasileira de Ciências (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652014000301537
Resumo: The aim of this study was to evaluate the relationship between testicular lesions and hormone levels in rats experimentally infected with Trypanosoma evansi. For that, the measurement of reproductive hormones, histopathology and biomarkers of cellular injury were carried out in twenty-four animals, which were divided into two groups with 12 animals each. Group A was the negative control, or uninfected, while group B was composed by animals infected with T. evansi. Both groups were divided again into two other subgroups (n=6), from which serum and testicular fragments were collected on days 5 (A1 and B1) and 15 (A2 and B2) post-infection (PI). The morphological analysis showed increased alterations of head and tail of sperm in infected rats when compared with those of the control group. A significant reduction (P<0.01) in the levels of LH, FSH, testosterone and estradiol, associated with an increase in cortisol, was observed in serum of group B when compared with negative control. Additionally, NOx, lipid peroxidation and protein oxidation were enhanced in testicles, indicating the occurrence of cellular lesion. On histopathology, it was possible to observe testicular degeneration, among other disorders in infected animals. Therefore, based on these results, it is possible to conclude that the experimental infection with T. evansi caused changes in the levels of the main hormones of male rats associated with cellular injury.
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spelling Relationship between testicular lesion and hormone levels in male rats infected with Trypanosoma evansiprotozoaWistar ratstesticular lesionreproductionoxidative stressThe aim of this study was to evaluate the relationship between testicular lesions and hormone levels in rats experimentally infected with Trypanosoma evansi. For that, the measurement of reproductive hormones, histopathology and biomarkers of cellular injury were carried out in twenty-four animals, which were divided into two groups with 12 animals each. Group A was the negative control, or uninfected, while group B was composed by animals infected with T. evansi. Both groups were divided again into two other subgroups (n=6), from which serum and testicular fragments were collected on days 5 (A1 and B1) and 15 (A2 and B2) post-infection (PI). The morphological analysis showed increased alterations of head and tail of sperm in infected rats when compared with those of the control group. A significant reduction (P<0.01) in the levels of LH, FSH, testosterone and estradiol, associated with an increase in cortisol, was observed in serum of group B when compared with negative control. Additionally, NOx, lipid peroxidation and protein oxidation were enhanced in testicles, indicating the occurrence of cellular lesion. On histopathology, it was possible to observe testicular degeneration, among other disorders in infected animals. Therefore, based on these results, it is possible to conclude that the experimental infection with T. evansi caused changes in the levels of the main hormones of male rats associated with cellular injury.Academia Brasileira de Ciências2014-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652014000301537Anais da Academia Brasileira de Ciências v.86 n.3 2014reponame:Anais da Academia Brasileira de Ciências (Online)instname:Academia Brasileira de Ciências (ABC)instacron:ABC10.1590/0001-3765201420130167info:eu-repo/semantics/openAccessFACCIO,LUCIANASILVA,ALEKSANDRO S. DATONIN,ALEXANDRE A.OBERHERR,LUCASGRESSLER,LUCAS T.OLIVEIRA,CAMILA B.OLIVEIRA,DIONATAN T.SANGOI,MANUELA B.MORESCO,RAFAEL N.SAMARA,YASMIN N.VEIGA,MARCELODUARTE,MARTA M.M.F.MONTEIRO,SILVIA G.eng2015-05-07T00:00:00Zoai:scielo:S0001-37652014000301537Revistahttp://www.scielo.br/aabchttps://old.scielo.br/oai/scielo-oai.php||aabc@abc.org.br1678-26900001-3765opendoar:2015-05-07T00:00Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC)false
dc.title.none.fl_str_mv Relationship between testicular lesion and hormone levels in male rats infected with Trypanosoma evansi
title Relationship between testicular lesion and hormone levels in male rats infected with Trypanosoma evansi
spellingShingle Relationship between testicular lesion and hormone levels in male rats infected with Trypanosoma evansi
FACCIO,LUCIANA
protozoa
Wistar rats
testicular lesion
reproduction
oxidative stress
title_short Relationship between testicular lesion and hormone levels in male rats infected with Trypanosoma evansi
title_full Relationship between testicular lesion and hormone levels in male rats infected with Trypanosoma evansi
title_fullStr Relationship between testicular lesion and hormone levels in male rats infected with Trypanosoma evansi
title_full_unstemmed Relationship between testicular lesion and hormone levels in male rats infected with Trypanosoma evansi
title_sort Relationship between testicular lesion and hormone levels in male rats infected with Trypanosoma evansi
author FACCIO,LUCIANA
author_facet FACCIO,LUCIANA
SILVA,ALEKSANDRO S. DA
TONIN,ALEXANDRE A.
OBERHERR,LUCAS
GRESSLER,LUCAS T.
OLIVEIRA,CAMILA B.
OLIVEIRA,DIONATAN T.
SANGOI,MANUELA B.
MORESCO,RAFAEL N.
SAMARA,YASMIN N.
VEIGA,MARCELO
DUARTE,MARTA M.M.F.
MONTEIRO,SILVIA G.
author_role author
author2 SILVA,ALEKSANDRO S. DA
TONIN,ALEXANDRE A.
OBERHERR,LUCAS
GRESSLER,LUCAS T.
OLIVEIRA,CAMILA B.
OLIVEIRA,DIONATAN T.
SANGOI,MANUELA B.
MORESCO,RAFAEL N.
SAMARA,YASMIN N.
VEIGA,MARCELO
DUARTE,MARTA M.M.F.
MONTEIRO,SILVIA G.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv FACCIO,LUCIANA
SILVA,ALEKSANDRO S. DA
TONIN,ALEXANDRE A.
OBERHERR,LUCAS
GRESSLER,LUCAS T.
OLIVEIRA,CAMILA B.
OLIVEIRA,DIONATAN T.
SANGOI,MANUELA B.
MORESCO,RAFAEL N.
SAMARA,YASMIN N.
VEIGA,MARCELO
DUARTE,MARTA M.M.F.
MONTEIRO,SILVIA G.
dc.subject.por.fl_str_mv protozoa
Wistar rats
testicular lesion
reproduction
oxidative stress
topic protozoa
Wistar rats
testicular lesion
reproduction
oxidative stress
description The aim of this study was to evaluate the relationship between testicular lesions and hormone levels in rats experimentally infected with Trypanosoma evansi. For that, the measurement of reproductive hormones, histopathology and biomarkers of cellular injury were carried out in twenty-four animals, which were divided into two groups with 12 animals each. Group A was the negative control, or uninfected, while group B was composed by animals infected with T. evansi. Both groups were divided again into two other subgroups (n=6), from which serum and testicular fragments were collected on days 5 (A1 and B1) and 15 (A2 and B2) post-infection (PI). The morphological analysis showed increased alterations of head and tail of sperm in infected rats when compared with those of the control group. A significant reduction (P<0.01) in the levels of LH, FSH, testosterone and estradiol, associated with an increase in cortisol, was observed in serum of group B when compared with negative control. Additionally, NOx, lipid peroxidation and protein oxidation were enhanced in testicles, indicating the occurrence of cellular lesion. On histopathology, it was possible to observe testicular degeneration, among other disorders in infected animals. Therefore, based on these results, it is possible to conclude that the experimental infection with T. evansi caused changes in the levels of the main hormones of male rats associated with cellular injury.
publishDate 2014
dc.date.none.fl_str_mv 2014-09-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652014000301537
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652014000301537
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0001-3765201420130167
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Ciências
publisher.none.fl_str_mv Academia Brasileira de Ciências
dc.source.none.fl_str_mv Anais da Academia Brasileira de Ciências v.86 n.3 2014
reponame:Anais da Academia Brasileira de Ciências (Online)
instname:Academia Brasileira de Ciências (ABC)
instacron:ABC
instname_str Academia Brasileira de Ciências (ABC)
instacron_str ABC
institution ABC
reponame_str Anais da Academia Brasileira de Ciências (Online)
collection Anais da Academia Brasileira de Ciências (Online)
repository.name.fl_str_mv Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC)
repository.mail.fl_str_mv ||aabc@abc.org.br
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