Effects of grape juice, red wine and resveratrol on liver parameters of rat submitted high-fat diet

Detalhes bibliográficos
Autor(a) principal: BEDÊ,TERESA P.
Data de Publicação: 2020
Outros Autores: JESUZ,VANESSA A., SOUZA,VANESSA R., ELIAS,MONIQUE B., OLIVEIRA,FELIPE L., DIAS,JULIANA F., TEODORO,ANDERSON J., AZEREDO,VILMA B.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Anais da Academia Brasileira de Ciências (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652020000300909
Resumo: Abstract This work evaluated the effect of grape juice, red wine and resveratrol in liver parameters of rats submitted to high-fat diet. Experimental model was conducted with groups of adult females Rattus norvegicus: control (CG); high-fat (HG); grape juice (JG); red wine (RW) and resveratrol solution (RG). The high-fat diet significantly altered hepatocytes and Kupffer cells in all treated groups. HG group presented severe steatosis followed hepatocyte ballooning and tissue damages. JG group minimized hepatic histological lesion caused by high-fat diet and WG group also induced steatosis and inflammation in hepatocytes, similar to HG. Still, resveratrol protected the tissue against fatty liver disease by reducing fat infiltration and inflammation, indicating possible therapeutic effects on the liver. Cell cycle analysis showed that HG promoted damage to the tissue, reducing the viable cell content and increasing apoptosis, even when associated with wine consumption or isolated resveratrol. However, JG protected the liver against cell damage generated by the diet. Consumption of grape juice, even associated with a high-fat diet, represents a promising protection of the liver against cellular damage, but red wine further affects the tissue, and resveratrol alone was able to reduce damage but did not minimize cellular damage to the liver.
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spelling Effects of grape juice, red wine and resveratrol on liver parameters of rat submitted high-fat dietGrape juicehigh-fat dietliverresveratrolwineAbstract This work evaluated the effect of grape juice, red wine and resveratrol in liver parameters of rats submitted to high-fat diet. Experimental model was conducted with groups of adult females Rattus norvegicus: control (CG); high-fat (HG); grape juice (JG); red wine (RW) and resveratrol solution (RG). The high-fat diet significantly altered hepatocytes and Kupffer cells in all treated groups. HG group presented severe steatosis followed hepatocyte ballooning and tissue damages. JG group minimized hepatic histological lesion caused by high-fat diet and WG group also induced steatosis and inflammation in hepatocytes, similar to HG. Still, resveratrol protected the tissue against fatty liver disease by reducing fat infiltration and inflammation, indicating possible therapeutic effects on the liver. Cell cycle analysis showed that HG promoted damage to the tissue, reducing the viable cell content and increasing apoptosis, even when associated with wine consumption or isolated resveratrol. However, JG protected the liver against cell damage generated by the diet. Consumption of grape juice, even associated with a high-fat diet, represents a promising protection of the liver against cellular damage, but red wine further affects the tissue, and resveratrol alone was able to reduce damage but did not minimize cellular damage to the liver.Academia Brasileira de Ciências2020-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652020000300909Anais da Academia Brasileira de Ciências v.92 n.2 2020reponame:Anais da Academia Brasileira de Ciências (Online)instname:Academia Brasileira de Ciências (ABC)instacron:ABC10.1590/0001-3765202020191230info:eu-repo/semantics/openAccessBEDÊ,TERESA P.JESUZ,VANESSA A.SOUZA,VANESSA R.ELIAS,MONIQUE B.OLIVEIRA,FELIPE L.DIAS,JULIANA F.TEODORO,ANDERSON J.AZEREDO,VILMA B.eng2020-08-07T00:00:00Zoai:scielo:S0001-37652020000300909Revistahttp://www.scielo.br/aabchttps://old.scielo.br/oai/scielo-oai.php||aabc@abc.org.br1678-26900001-3765opendoar:2020-08-07T00:00Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC)false
dc.title.none.fl_str_mv Effects of grape juice, red wine and resveratrol on liver parameters of rat submitted high-fat diet
title Effects of grape juice, red wine and resveratrol on liver parameters of rat submitted high-fat diet
spellingShingle Effects of grape juice, red wine and resveratrol on liver parameters of rat submitted high-fat diet
BEDÊ,TERESA P.
Grape juice
high-fat diet
liver
resveratrol
wine
title_short Effects of grape juice, red wine and resveratrol on liver parameters of rat submitted high-fat diet
title_full Effects of grape juice, red wine and resveratrol on liver parameters of rat submitted high-fat diet
title_fullStr Effects of grape juice, red wine and resveratrol on liver parameters of rat submitted high-fat diet
title_full_unstemmed Effects of grape juice, red wine and resveratrol on liver parameters of rat submitted high-fat diet
title_sort Effects of grape juice, red wine and resveratrol on liver parameters of rat submitted high-fat diet
author BEDÊ,TERESA P.
author_facet BEDÊ,TERESA P.
JESUZ,VANESSA A.
SOUZA,VANESSA R.
ELIAS,MONIQUE B.
OLIVEIRA,FELIPE L.
DIAS,JULIANA F.
TEODORO,ANDERSON J.
AZEREDO,VILMA B.
author_role author
author2 JESUZ,VANESSA A.
SOUZA,VANESSA R.
ELIAS,MONIQUE B.
OLIVEIRA,FELIPE L.
DIAS,JULIANA F.
TEODORO,ANDERSON J.
AZEREDO,VILMA B.
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv BEDÊ,TERESA P.
JESUZ,VANESSA A.
SOUZA,VANESSA R.
ELIAS,MONIQUE B.
OLIVEIRA,FELIPE L.
DIAS,JULIANA F.
TEODORO,ANDERSON J.
AZEREDO,VILMA B.
dc.subject.por.fl_str_mv Grape juice
high-fat diet
liver
resveratrol
wine
topic Grape juice
high-fat diet
liver
resveratrol
wine
description Abstract This work evaluated the effect of grape juice, red wine and resveratrol in liver parameters of rats submitted to high-fat diet. Experimental model was conducted with groups of adult females Rattus norvegicus: control (CG); high-fat (HG); grape juice (JG); red wine (RW) and resveratrol solution (RG). The high-fat diet significantly altered hepatocytes and Kupffer cells in all treated groups. HG group presented severe steatosis followed hepatocyte ballooning and tissue damages. JG group minimized hepatic histological lesion caused by high-fat diet and WG group also induced steatosis and inflammation in hepatocytes, similar to HG. Still, resveratrol protected the tissue against fatty liver disease by reducing fat infiltration and inflammation, indicating possible therapeutic effects on the liver. Cell cycle analysis showed that HG promoted damage to the tissue, reducing the viable cell content and increasing apoptosis, even when associated with wine consumption or isolated resveratrol. However, JG protected the liver against cell damage generated by the diet. Consumption of grape juice, even associated with a high-fat diet, represents a promising protection of the liver against cellular damage, but red wine further affects the tissue, and resveratrol alone was able to reduce damage but did not minimize cellular damage to the liver.
publishDate 2020
dc.date.none.fl_str_mv 2020-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652020000300909
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652020000300909
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0001-3765202020191230
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Ciências
publisher.none.fl_str_mv Academia Brasileira de Ciências
dc.source.none.fl_str_mv Anais da Academia Brasileira de Ciências v.92 n.2 2020
reponame:Anais da Academia Brasileira de Ciências (Online)
instname:Academia Brasileira de Ciências (ABC)
instacron:ABC
instname_str Academia Brasileira de Ciências (ABC)
instacron_str ABC
institution ABC
reponame_str Anais da Academia Brasileira de Ciências (Online)
collection Anais da Academia Brasileira de Ciências (Online)
repository.name.fl_str_mv Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC)
repository.mail.fl_str_mv ||aabc@abc.org.br
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