Cytotoxic sesquiterpene lactones from the aerial parts of Inula aucheriana.

Detalhes bibliográficos
Autor(a) principal: Gohari,Ahmad Reza
Data de Publicação: 2015
Outros Autores: Mosaddegh,Mahmoud, Naghibi,Farzaneh, Eslami-Tehrani,Bahara, Pirani,Atefeh, Hamzeloo-Moghadam,Maryam, Read,Roger W.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Anais da Academia Brasileira de Ciências (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652015000200777
Resumo: Inula aucheriana DC is a member of the family Asteraceae which is known to produce cytotoxic secondary metabolites noted as sesquiterpene lactones. In the present study, sesquiterpene lactones inuchinenolide B, 6-deoxychamissonolide (stevin) and 14-acetoxy-1β,5α,7αH-4β-hydroxy-guai-9(10),11(13)-dien-12,8α-olide were isolated from I. aucheriana. Inuchinenolide B and 14-acetoxy-1β,5α,7αH-4β-hydroxy-guai-9(10),11(13)-dien-12,8α-olide were further evaluated by the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) assay to demonstrate cytotoxic activity with IC50 values of (56.6, 19.0), (39.0, 11.8), and (55.7, 15.3) μg/mL against HepG-2, MCF-7 and A-549 cells, respectively. The cytotoxic activity of the two evaluated sesquiterpene lactones partly explains the cytotoxic activity that was previously observed for the extracts of Inula aucheriana. The isolated compounds could be further investigated in cancer research studies.
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spelling Cytotoxic sesquiterpene lactones from the aerial parts of Inula aucheriana.cytotoxicityInula aucherianaMTT assaysesquiterpene lactonesInula aucheriana DC is a member of the family Asteraceae which is known to produce cytotoxic secondary metabolites noted as sesquiterpene lactones. In the present study, sesquiterpene lactones inuchinenolide B, 6-deoxychamissonolide (stevin) and 14-acetoxy-1β,5α,7αH-4β-hydroxy-guai-9(10),11(13)-dien-12,8α-olide were isolated from I. aucheriana. Inuchinenolide B and 14-acetoxy-1β,5α,7αH-4β-hydroxy-guai-9(10),11(13)-dien-12,8α-olide were further evaluated by the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) assay to demonstrate cytotoxic activity with IC50 values of (56.6, 19.0), (39.0, 11.8), and (55.7, 15.3) μg/mL against HepG-2, MCF-7 and A-549 cells, respectively. The cytotoxic activity of the two evaluated sesquiterpene lactones partly explains the cytotoxic activity that was previously observed for the extracts of Inula aucheriana. The isolated compounds could be further investigated in cancer research studies.Academia Brasileira de Ciências2015-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652015000200777Anais da Academia Brasileira de Ciências v.87 n.2 2015reponame:Anais da Academia Brasileira de Ciências (Online)instname:Academia Brasileira de Ciências (ABC)instacron:ABC10.1590/0001-3765201520140063info:eu-repo/semantics/openAccessGohari,Ahmad RezaMosaddegh,MahmoudNaghibi,FarzanehEslami-Tehrani,BaharaPirani,AtefehHamzeloo-Moghadam,MaryamRead,Roger W.eng2016-03-04T00:00:00Zoai:scielo:S0001-37652015000200777Revistahttp://www.scielo.br/aabchttps://old.scielo.br/oai/scielo-oai.php||aabc@abc.org.br1678-26900001-3765opendoar:2016-03-04T00:00Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC)false
dc.title.none.fl_str_mv Cytotoxic sesquiterpene lactones from the aerial parts of Inula aucheriana.
title Cytotoxic sesquiterpene lactones from the aerial parts of Inula aucheriana.
spellingShingle Cytotoxic sesquiterpene lactones from the aerial parts of Inula aucheriana.
Gohari,Ahmad Reza
cytotoxicity
Inula aucheriana
MTT assay
sesquiterpene lactones
title_short Cytotoxic sesquiterpene lactones from the aerial parts of Inula aucheriana.
title_full Cytotoxic sesquiterpene lactones from the aerial parts of Inula aucheriana.
title_fullStr Cytotoxic sesquiterpene lactones from the aerial parts of Inula aucheriana.
title_full_unstemmed Cytotoxic sesquiterpene lactones from the aerial parts of Inula aucheriana.
title_sort Cytotoxic sesquiterpene lactones from the aerial parts of Inula aucheriana.
author Gohari,Ahmad Reza
author_facet Gohari,Ahmad Reza
Mosaddegh,Mahmoud
Naghibi,Farzaneh
Eslami-Tehrani,Bahara
Pirani,Atefeh
Hamzeloo-Moghadam,Maryam
Read,Roger W.
author_role author
author2 Mosaddegh,Mahmoud
Naghibi,Farzaneh
Eslami-Tehrani,Bahara
Pirani,Atefeh
Hamzeloo-Moghadam,Maryam
Read,Roger W.
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Gohari,Ahmad Reza
Mosaddegh,Mahmoud
Naghibi,Farzaneh
Eslami-Tehrani,Bahara
Pirani,Atefeh
Hamzeloo-Moghadam,Maryam
Read,Roger W.
dc.subject.por.fl_str_mv cytotoxicity
Inula aucheriana
MTT assay
sesquiterpene lactones
topic cytotoxicity
Inula aucheriana
MTT assay
sesquiterpene lactones
description Inula aucheriana DC is a member of the family Asteraceae which is known to produce cytotoxic secondary metabolites noted as sesquiterpene lactones. In the present study, sesquiterpene lactones inuchinenolide B, 6-deoxychamissonolide (stevin) and 14-acetoxy-1β,5α,7αH-4β-hydroxy-guai-9(10),11(13)-dien-12,8α-olide were isolated from I. aucheriana. Inuchinenolide B and 14-acetoxy-1β,5α,7αH-4β-hydroxy-guai-9(10),11(13)-dien-12,8α-olide were further evaluated by the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) assay to demonstrate cytotoxic activity with IC50 values of (56.6, 19.0), (39.0, 11.8), and (55.7, 15.3) μg/mL against HepG-2, MCF-7 and A-549 cells, respectively. The cytotoxic activity of the two evaluated sesquiterpene lactones partly explains the cytotoxic activity that was previously observed for the extracts of Inula aucheriana. The isolated compounds could be further investigated in cancer research studies.
publishDate 2015
dc.date.none.fl_str_mv 2015-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652015000200777
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652015000200777
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0001-3765201520140063
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Ciências
publisher.none.fl_str_mv Academia Brasileira de Ciências
dc.source.none.fl_str_mv Anais da Academia Brasileira de Ciências v.87 n.2 2015
reponame:Anais da Academia Brasileira de Ciências (Online)
instname:Academia Brasileira de Ciências (ABC)
instacron:ABC
instname_str Academia Brasileira de Ciências (ABC)
instacron_str ABC
institution ABC
reponame_str Anais da Academia Brasileira de Ciências (Online)
collection Anais da Academia Brasileira de Ciências (Online)
repository.name.fl_str_mv Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC)
repository.mail.fl_str_mv ||aabc@abc.org.br
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