Relationship between periodontal outcomes and serum biomarkers changes after non-surgical periodontal therapy

Detalhes bibliográficos
Autor(a) principal: LOBÃO,WALDER J.M.
Data de Publicação: 2019
Outros Autores: CARVALHO,ROSANA C.C. DE, LEITE,SANDRA A.M., RODRIGUES,VANDILSON P., BATISTA,JOSÉ EDUARDO, GOMES-FILHO,ISAAC S., PEREIRA,ANTONIO L.A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Anais da Academia Brasileira de Ciências (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000300805
Resumo: Abstract: The systemic effect of chronic periodontitis (CP) has been suggested by several studies as an etiologic factor and modulator of diseases based on the changes in the inflammatory marker levels. This study aimed to investigate the relationship between the changes in clinical periodontal outcomes and serum biomarkers (CRP, IL-6, albumin and percentage of leukocytes) after non-surgical periodontal therapy in systemically healthy adults. An interventional study was conducted with a sample of 29 individuals without CP (control group) and 33 with CP (CP group). Periodontal clinical variables were recorded, and the serum levels of inflammatory markers were measured. Statistical analysis included the chi-square and Student’s t-tests and Pearson’s correlation analysis. After 90 days of non-surgical periodontal treatment, a reduction of periodontal parameters and IL-6 in both groups could be observed (P < 0.001). The correlation analysis revealed a directly proportional correlation between changes in the probing depth (r = 0.349, P = 0.049) and clinical attachment level (r = 0.374, P = 0.034) with CRP in the CP group. The findings suggest a reduction of IL-6 serum concentration and periodontal clinical measures 90 days after periodontal therapy in both groups.
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spelling Relationship between periodontal outcomes and serum biomarkers changes after non-surgical periodontal therapyChronic periodontitisInflammation mediatorsInterleukin-6C-reactive proteinLeukocytesAbstract: The systemic effect of chronic periodontitis (CP) has been suggested by several studies as an etiologic factor and modulator of diseases based on the changes in the inflammatory marker levels. This study aimed to investigate the relationship between the changes in clinical periodontal outcomes and serum biomarkers (CRP, IL-6, albumin and percentage of leukocytes) after non-surgical periodontal therapy in systemically healthy adults. An interventional study was conducted with a sample of 29 individuals without CP (control group) and 33 with CP (CP group). Periodontal clinical variables were recorded, and the serum levels of inflammatory markers were measured. Statistical analysis included the chi-square and Student’s t-tests and Pearson’s correlation analysis. After 90 days of non-surgical periodontal treatment, a reduction of periodontal parameters and IL-6 in both groups could be observed (P < 0.001). The correlation analysis revealed a directly proportional correlation between changes in the probing depth (r = 0.349, P = 0.049) and clinical attachment level (r = 0.374, P = 0.034) with CRP in the CP group. The findings suggest a reduction of IL-6 serum concentration and periodontal clinical measures 90 days after periodontal therapy in both groups.Academia Brasileira de Ciências2019-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000300805Anais da Academia Brasileira de Ciências v.91 n.2 2019reponame:Anais da Academia Brasileira de Ciências (Online)instname:Academia Brasileira de Ciências (ABC)instacron:ABC10.1590/0001-3765201920170652info:eu-repo/semantics/openAccessLOBÃO,WALDER J.M.CARVALHO,ROSANA C.C. DELEITE,SANDRA A.M.RODRIGUES,VANDILSON P.BATISTA,JOSÉ EDUARDOGOMES-FILHO,ISAAC S.PEREIRA,ANTONIO L.A.eng2019-06-05T00:00:00Zoai:scielo:S0001-37652019000300805Revistahttp://www.scielo.br/aabchttps://old.scielo.br/oai/scielo-oai.php||aabc@abc.org.br1678-26900001-3765opendoar:2019-06-05T00:00Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC)false
dc.title.none.fl_str_mv Relationship between periodontal outcomes and serum biomarkers changes after non-surgical periodontal therapy
title Relationship between periodontal outcomes and serum biomarkers changes after non-surgical periodontal therapy
spellingShingle Relationship between periodontal outcomes and serum biomarkers changes after non-surgical periodontal therapy
LOBÃO,WALDER J.M.
Chronic periodontitis
Inflammation mediators
Interleukin-6
C-reactive protein
Leukocytes
title_short Relationship between periodontal outcomes and serum biomarkers changes after non-surgical periodontal therapy
title_full Relationship between periodontal outcomes and serum biomarkers changes after non-surgical periodontal therapy
title_fullStr Relationship between periodontal outcomes and serum biomarkers changes after non-surgical periodontal therapy
title_full_unstemmed Relationship between periodontal outcomes and serum biomarkers changes after non-surgical periodontal therapy
title_sort Relationship between periodontal outcomes and serum biomarkers changes after non-surgical periodontal therapy
author LOBÃO,WALDER J.M.
author_facet LOBÃO,WALDER J.M.
CARVALHO,ROSANA C.C. DE
LEITE,SANDRA A.M.
RODRIGUES,VANDILSON P.
BATISTA,JOSÉ EDUARDO
GOMES-FILHO,ISAAC S.
PEREIRA,ANTONIO L.A.
author_role author
author2 CARVALHO,ROSANA C.C. DE
LEITE,SANDRA A.M.
RODRIGUES,VANDILSON P.
BATISTA,JOSÉ EDUARDO
GOMES-FILHO,ISAAC S.
PEREIRA,ANTONIO L.A.
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv LOBÃO,WALDER J.M.
CARVALHO,ROSANA C.C. DE
LEITE,SANDRA A.M.
RODRIGUES,VANDILSON P.
BATISTA,JOSÉ EDUARDO
GOMES-FILHO,ISAAC S.
PEREIRA,ANTONIO L.A.
dc.subject.por.fl_str_mv Chronic periodontitis
Inflammation mediators
Interleukin-6
C-reactive protein
Leukocytes
topic Chronic periodontitis
Inflammation mediators
Interleukin-6
C-reactive protein
Leukocytes
description Abstract: The systemic effect of chronic periodontitis (CP) has been suggested by several studies as an etiologic factor and modulator of diseases based on the changes in the inflammatory marker levels. This study aimed to investigate the relationship between the changes in clinical periodontal outcomes and serum biomarkers (CRP, IL-6, albumin and percentage of leukocytes) after non-surgical periodontal therapy in systemically healthy adults. An interventional study was conducted with a sample of 29 individuals without CP (control group) and 33 with CP (CP group). Periodontal clinical variables were recorded, and the serum levels of inflammatory markers were measured. Statistical analysis included the chi-square and Student’s t-tests and Pearson’s correlation analysis. After 90 days of non-surgical periodontal treatment, a reduction of periodontal parameters and IL-6 in both groups could be observed (P < 0.001). The correlation analysis revealed a directly proportional correlation between changes in the probing depth (r = 0.349, P = 0.049) and clinical attachment level (r = 0.374, P = 0.034) with CRP in the CP group. The findings suggest a reduction of IL-6 serum concentration and periodontal clinical measures 90 days after periodontal therapy in both groups.
publishDate 2019
dc.date.none.fl_str_mv 2019-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000300805
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000300805
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0001-3765201920170652
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Academia Brasileira de Ciências
publisher.none.fl_str_mv Academia Brasileira de Ciências
dc.source.none.fl_str_mv Anais da Academia Brasileira de Ciências v.91 n.2 2019
reponame:Anais da Academia Brasileira de Ciências (Online)
instname:Academia Brasileira de Ciências (ABC)
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instname_str Academia Brasileira de Ciências (ABC)
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institution ABC
reponame_str Anais da Academia Brasileira de Ciências (Online)
collection Anais da Academia Brasileira de Ciências (Online)
repository.name.fl_str_mv Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC)
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