Evaluation of Bcl-2, Bcl-x and Cleaved Caspase-3 in Malignant Peripheral Nerve Sheath Tumors and Neurofibromas

Detalhes bibliográficos
Autor(a) principal: CUNHA,KARIN S.
Data de Publicação: 2013
Outros Autores: CARUSO,ANABELA C., FARIA,PAULO A., SILVA,LICíNIO E. DA, FONSECA,ELIENE C. DA, GELLER,MAURO, MOURA-NETO,RODRIGO S. DE, LOPES,VÂNIA S.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Anais da Academia Brasileira de Ciências (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652013000401497
Resumo: ABSTRACTAIMSTo study the expression of Bcl-2, Bcl-x, as well the presence of cleaved caspase-3 in neurofibromas and malignant peripheral nerve sheath tumors. The expression of Bcl-2 and Bcl-x and the presence of cleaved caspase 3 were compared to clinicopathological features of malignant peripheral nerve sheath tumors and their impact on survival rates were also investigated.MATERIALS AND METHODSThe evaluation of Bcl-2, Bcl-x and cleaved caspase-3 was performed by immunohistochemistry using tissue microarrays in 28 malignant peripheral nerve sheath tumors and 38 neurofibromas. Immunoquantification was performed by computerized digital image analysis.CONCLUSIONSApoptosis is altered in neurofibromas and mainly in malignant peripheral nerve sheath tumors. High levels of cleaved caspase-3 are more common in tumors with more aggressive histological features and it is associated with lower disease free survival of patients with malignant peripheral nerve sheath tumors.
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spelling Evaluation of Bcl-2, Bcl-x and Cleaved Caspase-3 in Malignant Peripheral Nerve Sheath Tumors and Neurofibromasapoptosis regulatory proteinsmalignant peripheral nervous sheath tumorsneurofibromaNeurofibromatosis 1ABSTRACTAIMSTo study the expression of Bcl-2, Bcl-x, as well the presence of cleaved caspase-3 in neurofibromas and malignant peripheral nerve sheath tumors. The expression of Bcl-2 and Bcl-x and the presence of cleaved caspase 3 were compared to clinicopathological features of malignant peripheral nerve sheath tumors and their impact on survival rates were also investigated.MATERIALS AND METHODSThe evaluation of Bcl-2, Bcl-x and cleaved caspase-3 was performed by immunohistochemistry using tissue microarrays in 28 malignant peripheral nerve sheath tumors and 38 neurofibromas. Immunoquantification was performed by computerized digital image analysis.CONCLUSIONSApoptosis is altered in neurofibromas and mainly in malignant peripheral nerve sheath tumors. High levels of cleaved caspase-3 are more common in tumors with more aggressive histological features and it is associated with lower disease free survival of patients with malignant peripheral nerve sheath tumors.Academia Brasileira de Ciências2013-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652013000401497Anais da Academia Brasileira de Ciências v.85 n.4 2013reponame:Anais da Academia Brasileira de Ciências (Online)instname:Academia Brasileira de Ciências (ABC)instacron:ABC10.1590/0001-3765201320120026info:eu-repo/semantics/openAccessCUNHA,KARIN S.CARUSO,ANABELA C.FARIA,PAULO A.SILVA,LICíNIO E. DAFONSECA,ELIENE C. DAGELLER,MAUROMOURA-NETO,RODRIGO S. DELOPES,VÂNIA S.eng2015-11-03T00:00:00Zoai:scielo:S0001-37652013000401497Revistahttp://www.scielo.br/aabchttps://old.scielo.br/oai/scielo-oai.php||aabc@abc.org.br1678-26900001-3765opendoar:2015-11-03T00:00Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC)false
dc.title.none.fl_str_mv Evaluation of Bcl-2, Bcl-x and Cleaved Caspase-3 in Malignant Peripheral Nerve Sheath Tumors and Neurofibromas
title Evaluation of Bcl-2, Bcl-x and Cleaved Caspase-3 in Malignant Peripheral Nerve Sheath Tumors and Neurofibromas
spellingShingle Evaluation of Bcl-2, Bcl-x and Cleaved Caspase-3 in Malignant Peripheral Nerve Sheath Tumors and Neurofibromas
CUNHA,KARIN S.
apoptosis regulatory proteins
malignant peripheral nervous sheath tumors
neurofibroma
Neurofibromatosis 1
title_short Evaluation of Bcl-2, Bcl-x and Cleaved Caspase-3 in Malignant Peripheral Nerve Sheath Tumors and Neurofibromas
title_full Evaluation of Bcl-2, Bcl-x and Cleaved Caspase-3 in Malignant Peripheral Nerve Sheath Tumors and Neurofibromas
title_fullStr Evaluation of Bcl-2, Bcl-x and Cleaved Caspase-3 in Malignant Peripheral Nerve Sheath Tumors and Neurofibromas
title_full_unstemmed Evaluation of Bcl-2, Bcl-x and Cleaved Caspase-3 in Malignant Peripheral Nerve Sheath Tumors and Neurofibromas
title_sort Evaluation of Bcl-2, Bcl-x and Cleaved Caspase-3 in Malignant Peripheral Nerve Sheath Tumors and Neurofibromas
author CUNHA,KARIN S.
author_facet CUNHA,KARIN S.
CARUSO,ANABELA C.
FARIA,PAULO A.
SILVA,LICíNIO E. DA
FONSECA,ELIENE C. DA
GELLER,MAURO
MOURA-NETO,RODRIGO S. DE
LOPES,VÂNIA S.
author_role author
author2 CARUSO,ANABELA C.
FARIA,PAULO A.
SILVA,LICíNIO E. DA
FONSECA,ELIENE C. DA
GELLER,MAURO
MOURA-NETO,RODRIGO S. DE
LOPES,VÂNIA S.
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv CUNHA,KARIN S.
CARUSO,ANABELA C.
FARIA,PAULO A.
SILVA,LICíNIO E. DA
FONSECA,ELIENE C. DA
GELLER,MAURO
MOURA-NETO,RODRIGO S. DE
LOPES,VÂNIA S.
dc.subject.por.fl_str_mv apoptosis regulatory proteins
malignant peripheral nervous sheath tumors
neurofibroma
Neurofibromatosis 1
topic apoptosis regulatory proteins
malignant peripheral nervous sheath tumors
neurofibroma
Neurofibromatosis 1
description ABSTRACTAIMSTo study the expression of Bcl-2, Bcl-x, as well the presence of cleaved caspase-3 in neurofibromas and malignant peripheral nerve sheath tumors. The expression of Bcl-2 and Bcl-x and the presence of cleaved caspase 3 were compared to clinicopathological features of malignant peripheral nerve sheath tumors and their impact on survival rates were also investigated.MATERIALS AND METHODSThe evaluation of Bcl-2, Bcl-x and cleaved caspase-3 was performed by immunohistochemistry using tissue microarrays in 28 malignant peripheral nerve sheath tumors and 38 neurofibromas. Immunoquantification was performed by computerized digital image analysis.CONCLUSIONSApoptosis is altered in neurofibromas and mainly in malignant peripheral nerve sheath tumors. High levels of cleaved caspase-3 are more common in tumors with more aggressive histological features and it is associated with lower disease free survival of patients with malignant peripheral nerve sheath tumors.
publishDate 2013
dc.date.none.fl_str_mv 2013-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652013000401497
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652013000401497
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0001-3765201320120026
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Ciências
publisher.none.fl_str_mv Academia Brasileira de Ciências
dc.source.none.fl_str_mv Anais da Academia Brasileira de Ciências v.85 n.4 2013
reponame:Anais da Academia Brasileira de Ciências (Online)
instname:Academia Brasileira de Ciências (ABC)
instacron:ABC
instname_str Academia Brasileira de Ciências (ABC)
instacron_str ABC
institution ABC
reponame_str Anais da Academia Brasileira de Ciências (Online)
collection Anais da Academia Brasileira de Ciências (Online)
repository.name.fl_str_mv Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC)
repository.mail.fl_str_mv ||aabc@abc.org.br
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