Apoptotic cell and phagocyte interplay: recognition and consequences in different cell systems

Detalhes bibliográficos
Autor(a) principal: Moreira,Maria Elisabete C.
Data de Publicação: 2004
Outros Autores: Barcinski,Marcello A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Anais da Academia Brasileira de Ciências (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652004000100009
Resumo: Cell death by apoptosis is characterized by specific biochemical changes, including the exposure of multiple ligands, expected to tag the dying cell for prompt recognition by phagocytes. In non-pathological conditions, an efficient clearance is assured by the redundant interaction between apoptotic cell ligands and multiple receptor molecules present on the engulfing cell surface. This review concentrates on the molecular interactions operating in mammalian and non-mammalian systems for apoptotic cell recognition, as well as on the consequences of their signaling. Furthermore, some cellular models where the exposure of the phosphatidylserine (PS) phospholipid, a classical hallmark of the apoptotic phenotype, is not followed by cell death will be discussed.
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spelling Apoptotic cell and phagocyte interplay: recognition and consequences in different cell systemscell deathapoptosisapoptotic cell recognitionapoptotic mimicryphagocyteintracellular signalingCell death by apoptosis is characterized by specific biochemical changes, including the exposure of multiple ligands, expected to tag the dying cell for prompt recognition by phagocytes. In non-pathological conditions, an efficient clearance is assured by the redundant interaction between apoptotic cell ligands and multiple receptor molecules present on the engulfing cell surface. This review concentrates on the molecular interactions operating in mammalian and non-mammalian systems for apoptotic cell recognition, as well as on the consequences of their signaling. Furthermore, some cellular models where the exposure of the phosphatidylserine (PS) phospholipid, a classical hallmark of the apoptotic phenotype, is not followed by cell death will be discussed.Academia Brasileira de Ciências2004-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652004000100009Anais da Academia Brasileira de Ciências v.76 n.1 2004reponame:Anais da Academia Brasileira de Ciências (Online)instname:Academia Brasileira de Ciências (ABC)instacron:ABC10.1590/S0001-37652004000100009info:eu-repo/semantics/openAccessMoreira,Maria Elisabete C.Barcinski,Marcello A.eng2004-02-17T00:00:00Zoai:scielo:S0001-37652004000100009Revistahttp://www.scielo.br/aabchttps://old.scielo.br/oai/scielo-oai.php||aabc@abc.org.br1678-26900001-3765opendoar:2004-02-17T00:00Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC)false
dc.title.none.fl_str_mv Apoptotic cell and phagocyte interplay: recognition and consequences in different cell systems
title Apoptotic cell and phagocyte interplay: recognition and consequences in different cell systems
spellingShingle Apoptotic cell and phagocyte interplay: recognition and consequences in different cell systems
Moreira,Maria Elisabete C.
cell death
apoptosis
apoptotic cell recognition
apoptotic mimicry
phagocyte
intracellular signaling
title_short Apoptotic cell and phagocyte interplay: recognition and consequences in different cell systems
title_full Apoptotic cell and phagocyte interplay: recognition and consequences in different cell systems
title_fullStr Apoptotic cell and phagocyte interplay: recognition and consequences in different cell systems
title_full_unstemmed Apoptotic cell and phagocyte interplay: recognition and consequences in different cell systems
title_sort Apoptotic cell and phagocyte interplay: recognition and consequences in different cell systems
author Moreira,Maria Elisabete C.
author_facet Moreira,Maria Elisabete C.
Barcinski,Marcello A.
author_role author
author2 Barcinski,Marcello A.
author2_role author
dc.contributor.author.fl_str_mv Moreira,Maria Elisabete C.
Barcinski,Marcello A.
dc.subject.por.fl_str_mv cell death
apoptosis
apoptotic cell recognition
apoptotic mimicry
phagocyte
intracellular signaling
topic cell death
apoptosis
apoptotic cell recognition
apoptotic mimicry
phagocyte
intracellular signaling
description Cell death by apoptosis is characterized by specific biochemical changes, including the exposure of multiple ligands, expected to tag the dying cell for prompt recognition by phagocytes. In non-pathological conditions, an efficient clearance is assured by the redundant interaction between apoptotic cell ligands and multiple receptor molecules present on the engulfing cell surface. This review concentrates on the molecular interactions operating in mammalian and non-mammalian systems for apoptotic cell recognition, as well as on the consequences of their signaling. Furthermore, some cellular models where the exposure of the phosphatidylserine (PS) phospholipid, a classical hallmark of the apoptotic phenotype, is not followed by cell death will be discussed.
publishDate 2004
dc.date.none.fl_str_mv 2004-03-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652004000100009
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652004000100009
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0001-37652004000100009
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Ciências
publisher.none.fl_str_mv Academia Brasileira de Ciências
dc.source.none.fl_str_mv Anais da Academia Brasileira de Ciências v.76 n.1 2004
reponame:Anais da Academia Brasileira de Ciências (Online)
instname:Academia Brasileira de Ciências (ABC)
instacron:ABC
instname_str Academia Brasileira de Ciências (ABC)
instacron_str ABC
institution ABC
reponame_str Anais da Academia Brasileira de Ciências (Online)
collection Anais da Academia Brasileira de Ciências (Online)
repository.name.fl_str_mv Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC)
repository.mail.fl_str_mv ||aabc@abc.org.br
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