Apoptotic cell and phagocyte interplay: recognition and consequences in different cell systems
Autor(a) principal: | |
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Data de Publicação: | 2004 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Anais da Academia Brasileira de Ciências (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652004000100009 |
Resumo: | Cell death by apoptosis is characterized by specific biochemical changes, including the exposure of multiple ligands, expected to tag the dying cell for prompt recognition by phagocytes. In non-pathological conditions, an efficient clearance is assured by the redundant interaction between apoptotic cell ligands and multiple receptor molecules present on the engulfing cell surface. This review concentrates on the molecular interactions operating in mammalian and non-mammalian systems for apoptotic cell recognition, as well as on the consequences of their signaling. Furthermore, some cellular models where the exposure of the phosphatidylserine (PS) phospholipid, a classical hallmark of the apoptotic phenotype, is not followed by cell death will be discussed. |
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Apoptotic cell and phagocyte interplay: recognition and consequences in different cell systemscell deathapoptosisapoptotic cell recognitionapoptotic mimicryphagocyteintracellular signalingCell death by apoptosis is characterized by specific biochemical changes, including the exposure of multiple ligands, expected to tag the dying cell for prompt recognition by phagocytes. In non-pathological conditions, an efficient clearance is assured by the redundant interaction between apoptotic cell ligands and multiple receptor molecules present on the engulfing cell surface. This review concentrates on the molecular interactions operating in mammalian and non-mammalian systems for apoptotic cell recognition, as well as on the consequences of their signaling. Furthermore, some cellular models where the exposure of the phosphatidylserine (PS) phospholipid, a classical hallmark of the apoptotic phenotype, is not followed by cell death will be discussed.Academia Brasileira de Ciências2004-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652004000100009Anais da Academia Brasileira de Ciências v.76 n.1 2004reponame:Anais da Academia Brasileira de Ciências (Online)instname:Academia Brasileira de Ciências (ABC)instacron:ABC10.1590/S0001-37652004000100009info:eu-repo/semantics/openAccessMoreira,Maria Elisabete C.Barcinski,Marcello A.eng2004-02-17T00:00:00Zoai:scielo:S0001-37652004000100009Revistahttp://www.scielo.br/aabchttps://old.scielo.br/oai/scielo-oai.php||aabc@abc.org.br1678-26900001-3765opendoar:2004-02-17T00:00Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC)false |
dc.title.none.fl_str_mv |
Apoptotic cell and phagocyte interplay: recognition and consequences in different cell systems |
title |
Apoptotic cell and phagocyte interplay: recognition and consequences in different cell systems |
spellingShingle |
Apoptotic cell and phagocyte interplay: recognition and consequences in different cell systems Moreira,Maria Elisabete C. cell death apoptosis apoptotic cell recognition apoptotic mimicry phagocyte intracellular signaling |
title_short |
Apoptotic cell and phagocyte interplay: recognition and consequences in different cell systems |
title_full |
Apoptotic cell and phagocyte interplay: recognition and consequences in different cell systems |
title_fullStr |
Apoptotic cell and phagocyte interplay: recognition and consequences in different cell systems |
title_full_unstemmed |
Apoptotic cell and phagocyte interplay: recognition and consequences in different cell systems |
title_sort |
Apoptotic cell and phagocyte interplay: recognition and consequences in different cell systems |
author |
Moreira,Maria Elisabete C. |
author_facet |
Moreira,Maria Elisabete C. Barcinski,Marcello A. |
author_role |
author |
author2 |
Barcinski,Marcello A. |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Moreira,Maria Elisabete C. Barcinski,Marcello A. |
dc.subject.por.fl_str_mv |
cell death apoptosis apoptotic cell recognition apoptotic mimicry phagocyte intracellular signaling |
topic |
cell death apoptosis apoptotic cell recognition apoptotic mimicry phagocyte intracellular signaling |
description |
Cell death by apoptosis is characterized by specific biochemical changes, including the exposure of multiple ligands, expected to tag the dying cell for prompt recognition by phagocytes. In non-pathological conditions, an efficient clearance is assured by the redundant interaction between apoptotic cell ligands and multiple receptor molecules present on the engulfing cell surface. This review concentrates on the molecular interactions operating in mammalian and non-mammalian systems for apoptotic cell recognition, as well as on the consequences of their signaling. Furthermore, some cellular models where the exposure of the phosphatidylserine (PS) phospholipid, a classical hallmark of the apoptotic phenotype, is not followed by cell death will be discussed. |
publishDate |
2004 |
dc.date.none.fl_str_mv |
2004-03-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652004000100009 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652004000100009 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0001-37652004000100009 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Ciências |
publisher.none.fl_str_mv |
Academia Brasileira de Ciências |
dc.source.none.fl_str_mv |
Anais da Academia Brasileira de Ciências v.76 n.1 2004 reponame:Anais da Academia Brasileira de Ciências (Online) instname:Academia Brasileira de Ciências (ABC) instacron:ABC |
instname_str |
Academia Brasileira de Ciências (ABC) |
instacron_str |
ABC |
institution |
ABC |
reponame_str |
Anais da Academia Brasileira de Ciências (Online) |
collection |
Anais da Academia Brasileira de Ciências (Online) |
repository.name.fl_str_mv |
Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC) |
repository.mail.fl_str_mv |
||aabc@abc.org.br |
_version_ |
1754302856085635072 |