Studies on the Synthesis of Vitamin D Analogs with Aromatic D-Ring

Detalhes bibliográficos
Autor(a) principal: EDUARDO-CANOSA,SILVINA
Data de Publicação: 2018
Outros Autores: SIGÜEIRO,MARÍA MARCO, RITA, MOURIÑO,ANTONIO
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Anais da Academia Brasileira de Ciências (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000301035
Resumo: ABSTRACT Herein, we describe our studies on the synthesis of 1α,25-dihydroxyvitamin D3 analogs possessing a benzene ring replacing the natural 5-membered D-ring by the Wittig-Horner and dienyne approaches. A key feature is the synthesis of a Cr(CO)3-complexed previtamin D derivative that enables the construction of vitamin D analogs with aromatic D-ring through a thermal [1,7]-H sigmatropic shift. This study establishes the basis for the design of new vitamin D analogs containing aromatic D-ring, complexed or uncomplexed to Cr(CO)3 type moieties for specific molecular recognition and drug research and development.
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spelling Studies on the Synthesis of Vitamin D Analogs with Aromatic D-RingD-ring modified vitamin D analogsaryl-Cr(CO)3 complexescancersigmatropic rearrangementssynthesisABSTRACT Herein, we describe our studies on the synthesis of 1α,25-dihydroxyvitamin D3 analogs possessing a benzene ring replacing the natural 5-membered D-ring by the Wittig-Horner and dienyne approaches. A key feature is the synthesis of a Cr(CO)3-complexed previtamin D derivative that enables the construction of vitamin D analogs with aromatic D-ring through a thermal [1,7]-H sigmatropic shift. This study establishes the basis for the design of new vitamin D analogs containing aromatic D-ring, complexed or uncomplexed to Cr(CO)3 type moieties for specific molecular recognition and drug research and development.Academia Brasileira de Ciências2018-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000301035Anais da Academia Brasileira de Ciências v.90 n.1 suppl.2 2018reponame:Anais da Academia Brasileira de Ciências (Online)instname:Academia Brasileira de Ciências (ABC)instacron:ABC10.1590/0001-3765201820170701info:eu-repo/semantics/openAccessEDUARDO-CANOSA,SILVINASIGÜEIRO,MARÍA MARCO, RITAMOURIÑO,ANTONIOeng2018-05-28T00:00:00Zoai:scielo:S0001-37652018000301035Revistahttp://www.scielo.br/aabchttps://old.scielo.br/oai/scielo-oai.php||aabc@abc.org.br1678-26900001-3765opendoar:2018-05-28T00:00Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC)false
dc.title.none.fl_str_mv Studies on the Synthesis of Vitamin D Analogs with Aromatic D-Ring
title Studies on the Synthesis of Vitamin D Analogs with Aromatic D-Ring
spellingShingle Studies on the Synthesis of Vitamin D Analogs with Aromatic D-Ring
EDUARDO-CANOSA,SILVINA
D-ring modified vitamin D analogs
aryl-Cr(CO)3 complexes
cancer
sigmatropic rearrangements
synthesis
title_short Studies on the Synthesis of Vitamin D Analogs with Aromatic D-Ring
title_full Studies on the Synthesis of Vitamin D Analogs with Aromatic D-Ring
title_fullStr Studies on the Synthesis of Vitamin D Analogs with Aromatic D-Ring
title_full_unstemmed Studies on the Synthesis of Vitamin D Analogs with Aromatic D-Ring
title_sort Studies on the Synthesis of Vitamin D Analogs with Aromatic D-Ring
author EDUARDO-CANOSA,SILVINA
author_facet EDUARDO-CANOSA,SILVINA
SIGÜEIRO,MARÍA MARCO, RITA
MOURIÑO,ANTONIO
author_role author
author2 SIGÜEIRO,MARÍA MARCO, RITA
MOURIÑO,ANTONIO
author2_role author
author
dc.contributor.author.fl_str_mv EDUARDO-CANOSA,SILVINA
SIGÜEIRO,MARÍA MARCO, RITA
MOURIÑO,ANTONIO
dc.subject.por.fl_str_mv D-ring modified vitamin D analogs
aryl-Cr(CO)3 complexes
cancer
sigmatropic rearrangements
synthesis
topic D-ring modified vitamin D analogs
aryl-Cr(CO)3 complexes
cancer
sigmatropic rearrangements
synthesis
description ABSTRACT Herein, we describe our studies on the synthesis of 1α,25-dihydroxyvitamin D3 analogs possessing a benzene ring replacing the natural 5-membered D-ring by the Wittig-Horner and dienyne approaches. A key feature is the synthesis of a Cr(CO)3-complexed previtamin D derivative that enables the construction of vitamin D analogs with aromatic D-ring through a thermal [1,7]-H sigmatropic shift. This study establishes the basis for the design of new vitamin D analogs containing aromatic D-ring, complexed or uncomplexed to Cr(CO)3 type moieties for specific molecular recognition and drug research and development.
publishDate 2018
dc.date.none.fl_str_mv 2018-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000301035
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000301035
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0001-3765201820170701
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Ciências
publisher.none.fl_str_mv Academia Brasileira de Ciências
dc.source.none.fl_str_mv Anais da Academia Brasileira de Ciências v.90 n.1 suppl.2 2018
reponame:Anais da Academia Brasileira de Ciências (Online)
instname:Academia Brasileira de Ciências (ABC)
instacron:ABC
instname_str Academia Brasileira de Ciências (ABC)
instacron_str ABC
institution ABC
reponame_str Anais da Academia Brasileira de Ciências (Online)
collection Anais da Academia Brasileira de Ciências (Online)
repository.name.fl_str_mv Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC)
repository.mail.fl_str_mv ||aabc@abc.org.br
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