Biflorin: an o-naphthoquinone of clinical significance

Detalhes bibliográficos
Autor(a) principal: WISINTAINER,GABRIELLE G.N.S.
Data de Publicação: 2014
Outros Autores: SIMÕES,EVELYNE R.B., LEMOS,TELMA L.G., MOURA,SIDNEI, SOUZA,LUCIANA G.S., FONSECA,ALUISIO M., MORAES,MANOEL ODORICO, PESSOA,CLAUDIA, ROESCH-ELY,MARIANA, HENRIQUES,JOÃO A.P.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Anais da Academia Brasileira de Ciências (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652014000401907
Resumo: Biflorin is an o-naphthoquinone with proven cytotoxic effects on tumor cells showing antimicrobial, antitumor and antimutagenic activities. Biflorin is an isolated compound taken from the roots of the plantCapraria biflora L. (Schrophulariaceae), indigenous of the West Indies and South America, which is located in temperate or tropical areas. This compound has shown to be strongly active against grampositive and alcohol-acid-resistant bacteria. It has been efficient in inhibiting the proliferation tumor cell lines CEM, HL-60, B16, HCT-8 and MCF-7. Recently, SK-Br3 cell line was treated with biflorin showing important cytotoxic effects. In this article, information related to the first structural characterization studies are presented, as well as the latest reports concerning the biological activity of this molecule.
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spelling Biflorin: an o-naphthoquinone of clinical significancebiological activityBiflorinCapraria bifloranatural productsBiflorin is an o-naphthoquinone with proven cytotoxic effects on tumor cells showing antimicrobial, antitumor and antimutagenic activities. Biflorin is an isolated compound taken from the roots of the plantCapraria biflora L. (Schrophulariaceae), indigenous of the West Indies and South America, which is located in temperate or tropical areas. This compound has shown to be strongly active against grampositive and alcohol-acid-resistant bacteria. It has been efficient in inhibiting the proliferation tumor cell lines CEM, HL-60, B16, HCT-8 and MCF-7. Recently, SK-Br3 cell line was treated with biflorin showing important cytotoxic effects. In this article, information related to the first structural characterization studies are presented, as well as the latest reports concerning the biological activity of this molecule.Academia Brasileira de Ciências2014-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652014000401907Anais da Academia Brasileira de Ciências v.86 n.4 2014reponame:Anais da Academia Brasileira de Ciências (Online)instname:Academia Brasileira de Ciências (ABC)instacron:ABC10.1590/0001-3765201420140085info:eu-repo/semantics/openAccessWISINTAINER,GABRIELLE G.N.S.SIMÕES,EVELYNE R.B.LEMOS,TELMA L.G.MOURA,SIDNEISOUZA,LUCIANA G.S.FONSECA,ALUISIO M.MORAES,MANOEL ODORICOPESSOA,CLAUDIAROESCH-ELY,MARIANAHENRIQUES,JOÃO A.P.eng2015-10-27T00:00:00Zoai:scielo:S0001-37652014000401907Revistahttp://www.scielo.br/aabchttps://old.scielo.br/oai/scielo-oai.php||aabc@abc.org.br1678-26900001-3765opendoar:2015-10-27T00:00Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC)false
dc.title.none.fl_str_mv Biflorin: an o-naphthoquinone of clinical significance
title Biflorin: an o-naphthoquinone of clinical significance
spellingShingle Biflorin: an o-naphthoquinone of clinical significance
WISINTAINER,GABRIELLE G.N.S.
biological activity
Biflorin
Capraria biflora
natural products
title_short Biflorin: an o-naphthoquinone of clinical significance
title_full Biflorin: an o-naphthoquinone of clinical significance
title_fullStr Biflorin: an o-naphthoquinone of clinical significance
title_full_unstemmed Biflorin: an o-naphthoquinone of clinical significance
title_sort Biflorin: an o-naphthoquinone of clinical significance
author WISINTAINER,GABRIELLE G.N.S.
author_facet WISINTAINER,GABRIELLE G.N.S.
SIMÕES,EVELYNE R.B.
LEMOS,TELMA L.G.
MOURA,SIDNEI
SOUZA,LUCIANA G.S.
FONSECA,ALUISIO M.
MORAES,MANOEL ODORICO
PESSOA,CLAUDIA
ROESCH-ELY,MARIANA
HENRIQUES,JOÃO A.P.
author_role author
author2 SIMÕES,EVELYNE R.B.
LEMOS,TELMA L.G.
MOURA,SIDNEI
SOUZA,LUCIANA G.S.
FONSECA,ALUISIO M.
MORAES,MANOEL ODORICO
PESSOA,CLAUDIA
ROESCH-ELY,MARIANA
HENRIQUES,JOÃO A.P.
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv WISINTAINER,GABRIELLE G.N.S.
SIMÕES,EVELYNE R.B.
LEMOS,TELMA L.G.
MOURA,SIDNEI
SOUZA,LUCIANA G.S.
FONSECA,ALUISIO M.
MORAES,MANOEL ODORICO
PESSOA,CLAUDIA
ROESCH-ELY,MARIANA
HENRIQUES,JOÃO A.P.
dc.subject.por.fl_str_mv biological activity
Biflorin
Capraria biflora
natural products
topic biological activity
Biflorin
Capraria biflora
natural products
description Biflorin is an o-naphthoquinone with proven cytotoxic effects on tumor cells showing antimicrobial, antitumor and antimutagenic activities. Biflorin is an isolated compound taken from the roots of the plantCapraria biflora L. (Schrophulariaceae), indigenous of the West Indies and South America, which is located in temperate or tropical areas. This compound has shown to be strongly active against grampositive and alcohol-acid-resistant bacteria. It has been efficient in inhibiting the proliferation tumor cell lines CEM, HL-60, B16, HCT-8 and MCF-7. Recently, SK-Br3 cell line was treated with biflorin showing important cytotoxic effects. In this article, information related to the first structural characterization studies are presented, as well as the latest reports concerning the biological activity of this molecule.
publishDate 2014
dc.date.none.fl_str_mv 2014-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652014000401907
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652014000401907
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0001-3765201420140085
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Ciências
publisher.none.fl_str_mv Academia Brasileira de Ciências
dc.source.none.fl_str_mv Anais da Academia Brasileira de Ciências v.86 n.4 2014
reponame:Anais da Academia Brasileira de Ciências (Online)
instname:Academia Brasileira de Ciências (ABC)
instacron:ABC
instname_str Academia Brasileira de Ciências (ABC)
instacron_str ABC
institution ABC
reponame_str Anais da Academia Brasileira de Ciências (Online)
collection Anais da Academia Brasileira de Ciências (Online)
repository.name.fl_str_mv Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC)
repository.mail.fl_str_mv ||aabc@abc.org.br
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