Nanoparticle-based therapy for respiratory diseases
Autor(a) principal: | |
---|---|
Data de Publicação: | 2013 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Anais da Academia Brasileira de Ciências (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652013000100137 |
Resumo: | Nanotechnology is an emerging science with the potential to create new materials and strategies involving manipulation of matter at the nanometer scale (<100 nm). With size-dependent properties, nanoparticles have introduced a new paradigm in pharmacotherapy – the possibility of cell-targeted drug delivery with minimal systemic side effects and toxicity. The present review provides a summary of published findings, especially regarding to nanoparticle formulations for lung diseases. The available data have shown some benefits with nanoparticle-based therapy in the development of the disease and lung remodeling in respiratory diseases. However, there is a wide gap between the concepts of nanomedicine and the published experimental data and clinical reality. In addition, studies are still required to determine the potential of nanotherapy and the systemic toxicity of nanomaterials for future human use. |
id |
ABC-1_d038194fe0eb11b339587bab6c8adfe8 |
---|---|
oai_identifier_str |
oai:scielo:S0001-37652013000100137 |
network_acronym_str |
ABC-1 |
network_name_str |
Anais da Academia Brasileira de Ciências (Online) |
repository_id_str |
|
spelling |
Nanoparticle-based therapy for respiratory diseasesasthmaturberculosisnanotechnologylung cancerNanotechnology is an emerging science with the potential to create new materials and strategies involving manipulation of matter at the nanometer scale (<100 nm). With size-dependent properties, nanoparticles have introduced a new paradigm in pharmacotherapy – the possibility of cell-targeted drug delivery with minimal systemic side effects and toxicity. The present review provides a summary of published findings, especially regarding to nanoparticle formulations for lung diseases. The available data have shown some benefits with nanoparticle-based therapy in the development of the disease and lung remodeling in respiratory diseases. However, there is a wide gap between the concepts of nanomedicine and the published experimental data and clinical reality. In addition, studies are still required to determine the potential of nanotherapy and the systemic toxicity of nanomaterials for future human use.Academia Brasileira de Ciências2013-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652013000100137Anais da Academia Brasileira de Ciências v.85 n.1 2013reponame:Anais da Academia Brasileira de Ciências (Online)instname:Academia Brasileira de Ciências (ABC)instacron:ABC10.1590/S0001-37652013005000018info:eu-repo/semantics/openAccessSILVA,ADRIANA L. DASANTOS,RAQUEL S.XISTO,DÉBORA G.ALONSO,SILVIA DEL V.MORALES,MARCELO M.ROCCO,PATRICIA R.M.eng2015-10-19T00:00:00Zoai:scielo:S0001-37652013000100137Revistahttp://www.scielo.br/aabchttps://old.scielo.br/oai/scielo-oai.php||aabc@abc.org.br1678-26900001-3765opendoar:2015-10-19T00:00Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC)false |
dc.title.none.fl_str_mv |
Nanoparticle-based therapy for respiratory diseases |
title |
Nanoparticle-based therapy for respiratory diseases |
spellingShingle |
Nanoparticle-based therapy for respiratory diseases SILVA,ADRIANA L. DA asthma turberculosis nanotechnology lung cancer |
title_short |
Nanoparticle-based therapy for respiratory diseases |
title_full |
Nanoparticle-based therapy for respiratory diseases |
title_fullStr |
Nanoparticle-based therapy for respiratory diseases |
title_full_unstemmed |
Nanoparticle-based therapy for respiratory diseases |
title_sort |
Nanoparticle-based therapy for respiratory diseases |
author |
SILVA,ADRIANA L. DA |
author_facet |
SILVA,ADRIANA L. DA SANTOS,RAQUEL S. XISTO,DÉBORA G. ALONSO,SILVIA DEL V. MORALES,MARCELO M. ROCCO,PATRICIA R.M. |
author_role |
author |
author2 |
SANTOS,RAQUEL S. XISTO,DÉBORA G. ALONSO,SILVIA DEL V. MORALES,MARCELO M. ROCCO,PATRICIA R.M. |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
SILVA,ADRIANA L. DA SANTOS,RAQUEL S. XISTO,DÉBORA G. ALONSO,SILVIA DEL V. MORALES,MARCELO M. ROCCO,PATRICIA R.M. |
dc.subject.por.fl_str_mv |
asthma turberculosis nanotechnology lung cancer |
topic |
asthma turberculosis nanotechnology lung cancer |
description |
Nanotechnology is an emerging science with the potential to create new materials and strategies involving manipulation of matter at the nanometer scale (<100 nm). With size-dependent properties, nanoparticles have introduced a new paradigm in pharmacotherapy – the possibility of cell-targeted drug delivery with minimal systemic side effects and toxicity. The present review provides a summary of published findings, especially regarding to nanoparticle formulations for lung diseases. The available data have shown some benefits with nanoparticle-based therapy in the development of the disease and lung remodeling in respiratory diseases. However, there is a wide gap between the concepts of nanomedicine and the published experimental data and clinical reality. In addition, studies are still required to determine the potential of nanotherapy and the systemic toxicity of nanomaterials for future human use. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-03-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652013000100137 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652013000100137 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0001-37652013005000018 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Ciências |
publisher.none.fl_str_mv |
Academia Brasileira de Ciências |
dc.source.none.fl_str_mv |
Anais da Academia Brasileira de Ciências v.85 n.1 2013 reponame:Anais da Academia Brasileira de Ciências (Online) instname:Academia Brasileira de Ciências (ABC) instacron:ABC |
instname_str |
Academia Brasileira de Ciências (ABC) |
instacron_str |
ABC |
institution |
ABC |
reponame_str |
Anais da Academia Brasileira de Ciências (Online) |
collection |
Anais da Academia Brasileira de Ciências (Online) |
repository.name.fl_str_mv |
Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC) |
repository.mail.fl_str_mv |
||aabc@abc.org.br |
_version_ |
1754302859141185536 |