Evaluation of the anti-inflammatory potential of Solidago microglossa (Arnica-brasileira) in vivo and its effects on PPARγ activity

Detalhes bibliográficos
Autor(a) principal: VOGAS,RITYELLO S.
Data de Publicação: 2020
Outros Autores: PEREIRA,MARIANA T.M., DUARTE,LUIZA S., CARNEIRO,MARA J., FARSURA,ANDREW F., MACHADO,JOÃO AUGUSTO M.M., COSTA,INGRID F., TOMÉ,MAYARA R.N., MILTON,FLORA A., NEVES,FRANCISCO A.R., ANDREO,MARCIO ADRIANO, LOPEZ,BEGOÑA GIMENEZ-CASSINA, SAWAYA,ALEXANDRA CHRISTINE HELENA F., PASCOAL,VINICIUS D’ÁVILA BITENCOURT, PASCOAL,AISLAN CRISTINA R.F.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Anais da Academia Brasileira de Ciências (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652020000300913
Resumo: Abstract Solidago microglossa is used as an anti-inflammatory agent in traditional Brazilian medicine, and this work evaluated the anti-inflammatory potential of the crude ethanolic extract of the flowers of S. microglossa in vivo, as assayed by paw edema models induced by carrageenan, prostaglandin E2, bradykinin and compound 48/80. In the chemical profile, we identified compounds by electrospray ionization mass spectrometry and quantified them by HPLC-DAD. Additionally, this study analyzed the potential to activate the in vitro transcriptional activity of PPARγ, which is a nuclear receptor linked to the anti-inflammatory response. It was possible to identify five compounds: quinic acid, quercetin, chlorogenic acid, hyperoside, and rutin. In the paw edema evaluation, it was possible to show the potential of reducing edema during the inflammatory process. The crude ethanolic extract of the flowers of S. microglossa activated PPARγ compared to the full agonist rosiglitazone and in a dose-response manner. It is possible to conclude that the extract of the flowers of S. microglossa showed anti-inflammatory activity, and the phenolic compounds present in this species might be responsible for this activity.
id ABC-1_e7f1287bdb9d39a81798b3539ea7a00b
oai_identifier_str oai:scielo:S0001-37652020000300913
network_acronym_str ABC-1
network_name_str Anais da Academia Brasileira de Ciências (Online)
repository_id_str
spelling Evaluation of the anti-inflammatory potential of Solidago microglossa (Arnica-brasileira) in vivo and its effects on PPARγ activitynatural productspopular useAsteraceaeinflammationchemical profileAbstract Solidago microglossa is used as an anti-inflammatory agent in traditional Brazilian medicine, and this work evaluated the anti-inflammatory potential of the crude ethanolic extract of the flowers of S. microglossa in vivo, as assayed by paw edema models induced by carrageenan, prostaglandin E2, bradykinin and compound 48/80. In the chemical profile, we identified compounds by electrospray ionization mass spectrometry and quantified them by HPLC-DAD. Additionally, this study analyzed the potential to activate the in vitro transcriptional activity of PPARγ, which is a nuclear receptor linked to the anti-inflammatory response. It was possible to identify five compounds: quinic acid, quercetin, chlorogenic acid, hyperoside, and rutin. In the paw edema evaluation, it was possible to show the potential of reducing edema during the inflammatory process. The crude ethanolic extract of the flowers of S. microglossa activated PPARγ compared to the full agonist rosiglitazone and in a dose-response manner. It is possible to conclude that the extract of the flowers of S. microglossa showed anti-inflammatory activity, and the phenolic compounds present in this species might be responsible for this activity.Academia Brasileira de Ciências2020-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652020000300913Anais da Academia Brasileira de Ciências v.92 n.2 2020reponame:Anais da Academia Brasileira de Ciências (Online)instname:Academia Brasileira de Ciências (ABC)instacron:ABC10.1590/0001-3765202020191201info:eu-repo/semantics/openAccessVOGAS,RITYELLO S.PEREIRA,MARIANA T.M.DUARTE,LUIZA S.CARNEIRO,MARA J.FARSURA,ANDREW F.MACHADO,JOÃO AUGUSTO M.M.COSTA,INGRID F.TOMÉ,MAYARA R.N.MILTON,FLORA A.NEVES,FRANCISCO A.R.ANDREO,MARCIO ADRIANOLOPEZ,BEGOÑA GIMENEZ-CASSINASAWAYA,ALEXANDRA CHRISTINE HELENA F.PASCOAL,VINICIUS D’ÁVILA BITENCOURTPASCOAL,AISLAN CRISTINA R.F.eng2020-08-10T00:00:00Zoai:scielo:S0001-37652020000300913Revistahttp://www.scielo.br/aabchttps://old.scielo.br/oai/scielo-oai.php||aabc@abc.org.br1678-26900001-3765opendoar:2020-08-10T00:00Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC)false
dc.title.none.fl_str_mv Evaluation of the anti-inflammatory potential of Solidago microglossa (Arnica-brasileira) in vivo and its effects on PPARγ activity
title Evaluation of the anti-inflammatory potential of Solidago microglossa (Arnica-brasileira) in vivo and its effects on PPARγ activity
spellingShingle Evaluation of the anti-inflammatory potential of Solidago microglossa (Arnica-brasileira) in vivo and its effects on PPARγ activity
VOGAS,RITYELLO S.
natural products
popular use
Asteraceae
inflammation
chemical profile
title_short Evaluation of the anti-inflammatory potential of Solidago microglossa (Arnica-brasileira) in vivo and its effects on PPARγ activity
title_full Evaluation of the anti-inflammatory potential of Solidago microglossa (Arnica-brasileira) in vivo and its effects on PPARγ activity
title_fullStr Evaluation of the anti-inflammatory potential of Solidago microglossa (Arnica-brasileira) in vivo and its effects on PPARγ activity
title_full_unstemmed Evaluation of the anti-inflammatory potential of Solidago microglossa (Arnica-brasileira) in vivo and its effects on PPARγ activity
title_sort Evaluation of the anti-inflammatory potential of Solidago microglossa (Arnica-brasileira) in vivo and its effects on PPARγ activity
author VOGAS,RITYELLO S.
author_facet VOGAS,RITYELLO S.
PEREIRA,MARIANA T.M.
DUARTE,LUIZA S.
CARNEIRO,MARA J.
FARSURA,ANDREW F.
MACHADO,JOÃO AUGUSTO M.M.
COSTA,INGRID F.
TOMÉ,MAYARA R.N.
MILTON,FLORA A.
NEVES,FRANCISCO A.R.
ANDREO,MARCIO ADRIANO
LOPEZ,BEGOÑA GIMENEZ-CASSINA
SAWAYA,ALEXANDRA CHRISTINE HELENA F.
PASCOAL,VINICIUS D’ÁVILA BITENCOURT
PASCOAL,AISLAN CRISTINA R.F.
author_role author
author2 PEREIRA,MARIANA T.M.
DUARTE,LUIZA S.
CARNEIRO,MARA J.
FARSURA,ANDREW F.
MACHADO,JOÃO AUGUSTO M.M.
COSTA,INGRID F.
TOMÉ,MAYARA R.N.
MILTON,FLORA A.
NEVES,FRANCISCO A.R.
ANDREO,MARCIO ADRIANO
LOPEZ,BEGOÑA GIMENEZ-CASSINA
SAWAYA,ALEXANDRA CHRISTINE HELENA F.
PASCOAL,VINICIUS D’ÁVILA BITENCOURT
PASCOAL,AISLAN CRISTINA R.F.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv VOGAS,RITYELLO S.
PEREIRA,MARIANA T.M.
DUARTE,LUIZA S.
CARNEIRO,MARA J.
FARSURA,ANDREW F.
MACHADO,JOÃO AUGUSTO M.M.
COSTA,INGRID F.
TOMÉ,MAYARA R.N.
MILTON,FLORA A.
NEVES,FRANCISCO A.R.
ANDREO,MARCIO ADRIANO
LOPEZ,BEGOÑA GIMENEZ-CASSINA
SAWAYA,ALEXANDRA CHRISTINE HELENA F.
PASCOAL,VINICIUS D’ÁVILA BITENCOURT
PASCOAL,AISLAN CRISTINA R.F.
dc.subject.por.fl_str_mv natural products
popular use
Asteraceae
inflammation
chemical profile
topic natural products
popular use
Asteraceae
inflammation
chemical profile
description Abstract Solidago microglossa is used as an anti-inflammatory agent in traditional Brazilian medicine, and this work evaluated the anti-inflammatory potential of the crude ethanolic extract of the flowers of S. microglossa in vivo, as assayed by paw edema models induced by carrageenan, prostaglandin E2, bradykinin and compound 48/80. In the chemical profile, we identified compounds by electrospray ionization mass spectrometry and quantified them by HPLC-DAD. Additionally, this study analyzed the potential to activate the in vitro transcriptional activity of PPARγ, which is a nuclear receptor linked to the anti-inflammatory response. It was possible to identify five compounds: quinic acid, quercetin, chlorogenic acid, hyperoside, and rutin. In the paw edema evaluation, it was possible to show the potential of reducing edema during the inflammatory process. The crude ethanolic extract of the flowers of S. microglossa activated PPARγ compared to the full agonist rosiglitazone and in a dose-response manner. It is possible to conclude that the extract of the flowers of S. microglossa showed anti-inflammatory activity, and the phenolic compounds present in this species might be responsible for this activity.
publishDate 2020
dc.date.none.fl_str_mv 2020-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652020000300913
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652020000300913
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0001-3765202020191201
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Ciências
publisher.none.fl_str_mv Academia Brasileira de Ciências
dc.source.none.fl_str_mv Anais da Academia Brasileira de Ciências v.92 n.2 2020
reponame:Anais da Academia Brasileira de Ciências (Online)
instname:Academia Brasileira de Ciências (ABC)
instacron:ABC
instname_str Academia Brasileira de Ciências (ABC)
instacron_str ABC
institution ABC
reponame_str Anais da Academia Brasileira de Ciências (Online)
collection Anais da Academia Brasileira de Ciências (Online)
repository.name.fl_str_mv Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC)
repository.mail.fl_str_mv ||aabc@abc.org.br
_version_ 1754302868924399616