In vitro anti-inflammatory effects of naturally-occurring compounds from two Lauraceae plants

Detalhes bibliográficos
Autor(a) principal: Coy-Barrera,Ericsson D.
Data de Publicação: 2011
Outros Autores: Cuca-Suarez,Luis E.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Anais da Academia Brasileira de Ciências (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652011000400026
Resumo: The in vitro anti-inflammatory effects of seven known lignans and one dihydrochalcone isolated from the leaves of two Lauraceae species (Pleurothyrium cinereum and Ocotea macrophylla), were evaluated through the inhibition of COX-1, COX-2, 5-LOX and the aggregation of rabbit platelets induced by PAF, AA and ADP. (+)-de-4"-O--methylmagnolin 4 was found to be a potent COX-2/5-LOX dual inhibitor and PAF-antagonist (COX-2 IC50 2.27 µM; 5-LOX IC50 5.05 µM; PAF IC50 2.51 µM). However, all compounds exhibited an activity at different levels, indicating good anti-inflammatory properties to be considered in further structural optimization studies.
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spelling In vitro anti-inflammatory effects of naturally-occurring compounds from two Lauraceae plantsCOXfurofuran lignans5-LOXOcotea macrophyllaplatelet aggregationPleurothyrium cinereumThe in vitro anti-inflammatory effects of seven known lignans and one dihydrochalcone isolated from the leaves of two Lauraceae species (Pleurothyrium cinereum and Ocotea macrophylla), were evaluated through the inhibition of COX-1, COX-2, 5-LOX and the aggregation of rabbit platelets induced by PAF, AA and ADP. (+)-de-4"-O--methylmagnolin 4 was found to be a potent COX-2/5-LOX dual inhibitor and PAF-antagonist (COX-2 IC50 2.27 µM; 5-LOX IC50 5.05 µM; PAF IC50 2.51 µM). However, all compounds exhibited an activity at different levels, indicating good anti-inflammatory properties to be considered in further structural optimization studies.Academia Brasileira de Ciências2011-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652011000400026Anais da Academia Brasileira de Ciências v.83 n.4 2011reponame:Anais da Academia Brasileira de Ciências (Online)instname:Academia Brasileira de Ciências (ABC)instacron:ABC10.1590/S0001-37652011005000044info:eu-repo/semantics/openAccessCoy-Barrera,Ericsson D.Cuca-Suarez,Luis E.eng2011-11-29T00:00:00Zoai:scielo:S0001-37652011000400026Revistahttp://www.scielo.br/aabchttps://old.scielo.br/oai/scielo-oai.php||aabc@abc.org.br1678-26900001-3765opendoar:2011-11-29T00:00Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC)false
dc.title.none.fl_str_mv In vitro anti-inflammatory effects of naturally-occurring compounds from two Lauraceae plants
title In vitro anti-inflammatory effects of naturally-occurring compounds from two Lauraceae plants
spellingShingle In vitro anti-inflammatory effects of naturally-occurring compounds from two Lauraceae plants
Coy-Barrera,Ericsson D.
COX
furofuran lignans
5-LOX
Ocotea macrophylla
platelet aggregation
Pleurothyrium cinereum
title_short In vitro anti-inflammatory effects of naturally-occurring compounds from two Lauraceae plants
title_full In vitro anti-inflammatory effects of naturally-occurring compounds from two Lauraceae plants
title_fullStr In vitro anti-inflammatory effects of naturally-occurring compounds from two Lauraceae plants
title_full_unstemmed In vitro anti-inflammatory effects of naturally-occurring compounds from two Lauraceae plants
title_sort In vitro anti-inflammatory effects of naturally-occurring compounds from two Lauraceae plants
author Coy-Barrera,Ericsson D.
author_facet Coy-Barrera,Ericsson D.
Cuca-Suarez,Luis E.
author_role author
author2 Cuca-Suarez,Luis E.
author2_role author
dc.contributor.author.fl_str_mv Coy-Barrera,Ericsson D.
Cuca-Suarez,Luis E.
dc.subject.por.fl_str_mv COX
furofuran lignans
5-LOX
Ocotea macrophylla
platelet aggregation
Pleurothyrium cinereum
topic COX
furofuran lignans
5-LOX
Ocotea macrophylla
platelet aggregation
Pleurothyrium cinereum
description The in vitro anti-inflammatory effects of seven known lignans and one dihydrochalcone isolated from the leaves of two Lauraceae species (Pleurothyrium cinereum and Ocotea macrophylla), were evaluated through the inhibition of COX-1, COX-2, 5-LOX and the aggregation of rabbit platelets induced by PAF, AA and ADP. (+)-de-4"-O--methylmagnolin 4 was found to be a potent COX-2/5-LOX dual inhibitor and PAF-antagonist (COX-2 IC50 2.27 µM; 5-LOX IC50 5.05 µM; PAF IC50 2.51 µM). However, all compounds exhibited an activity at different levels, indicating good anti-inflammatory properties to be considered in further structural optimization studies.
publishDate 2011
dc.date.none.fl_str_mv 2011-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652011000400026
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652011000400026
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0001-37652011005000044
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Ciências
publisher.none.fl_str_mv Academia Brasileira de Ciências
dc.source.none.fl_str_mv Anais da Academia Brasileira de Ciências v.83 n.4 2011
reponame:Anais da Academia Brasileira de Ciências (Online)
instname:Academia Brasileira de Ciências (ABC)
instacron:ABC
instname_str Academia Brasileira de Ciências (ABC)
instacron_str ABC
institution ABC
reponame_str Anais da Academia Brasileira de Ciências (Online)
collection Anais da Academia Brasileira de Ciências (Online)
repository.name.fl_str_mv Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC)
repository.mail.fl_str_mv ||aabc@abc.org.br
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