Modulatory effects of rutin on biochemical and hematological parameters in hypercholesterolemic Golden Syrian hamsters

Detalhes bibliográficos
Autor(a) principal: Kanashiro,Alexandre
Data de Publicação: 2009
Outros Autores: Andrade,Daiani C.O., Kabeya,Luciana M., Turato,Walter M., Faccioli,Lucia H., Uyemura,Sérgio A., Lucisano-Valim,Yara M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Anais da Academia Brasileira de Ciências (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652009000100009
Resumo: Flavonoids have been reported to exhibit several pharmacological properties, mainly in cardiovascular and inflammatory diseases. In the present study, we observed that rutin, a known glycosylated flavonoid isolated from Dimorphandra mollis, had a lowering effect on plasma triglyceride levels of diet-induced hypercholesterolemic Golden Syrian hamsters, but did not change total cholesterol and high-density lipoprotein cholesterol levels. Moreover, high-fat or rutin supplemented diets showed no immunotoxic effects, since no significant changes were observed on total white blood cells, granulocytes and mononuclear cells, as well as on the neutrophil apoptosis degree, when compared to untreated animals. Therefore, rutin seems to be a selective and non-toxic modulator of hypercholesterolemia, which can be promising for the development of new drugs.
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spelling Modulatory effects of rutin on biochemical and hematological parameters in hypercholesterolemic Golden Syrian hamstersrutinGolden Syrian hamsterhypercholesterolemiaatherosclerosisapoptosisDimorphandra mollisFlavonoids have been reported to exhibit several pharmacological properties, mainly in cardiovascular and inflammatory diseases. In the present study, we observed that rutin, a known glycosylated flavonoid isolated from Dimorphandra mollis, had a lowering effect on plasma triglyceride levels of diet-induced hypercholesterolemic Golden Syrian hamsters, but did not change total cholesterol and high-density lipoprotein cholesterol levels. Moreover, high-fat or rutin supplemented diets showed no immunotoxic effects, since no significant changes were observed on total white blood cells, granulocytes and mononuclear cells, as well as on the neutrophil apoptosis degree, when compared to untreated animals. Therefore, rutin seems to be a selective and non-toxic modulator of hypercholesterolemia, which can be promising for the development of new drugs.Academia Brasileira de Ciências2009-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652009000100009Anais da Academia Brasileira de Ciências v.81 n.1 2009reponame:Anais da Academia Brasileira de Ciências (Online)instname:Academia Brasileira de Ciências (ABC)instacron:ABC10.1590/S0001-37652009000100009info:eu-repo/semantics/openAccessKanashiro,AlexandreAndrade,Daiani C.O.Kabeya,Luciana M.Turato,Walter M.Faccioli,Lucia H.Uyemura,Sérgio A.Lucisano-Valim,Yara M.eng2009-02-19T00:00:00Zoai:scielo:S0001-37652009000100009Revistahttp://www.scielo.br/aabchttps://old.scielo.br/oai/scielo-oai.php||aabc@abc.org.br1678-26900001-3765opendoar:2009-02-19T00:00Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC)false
dc.title.none.fl_str_mv Modulatory effects of rutin on biochemical and hematological parameters in hypercholesterolemic Golden Syrian hamsters
title Modulatory effects of rutin on biochemical and hematological parameters in hypercholesterolemic Golden Syrian hamsters
spellingShingle Modulatory effects of rutin on biochemical and hematological parameters in hypercholesterolemic Golden Syrian hamsters
Kanashiro,Alexandre
rutin
Golden Syrian hamster
hypercholesterolemia
atherosclerosis
apoptosis
Dimorphandra mollis
title_short Modulatory effects of rutin on biochemical and hematological parameters in hypercholesterolemic Golden Syrian hamsters
title_full Modulatory effects of rutin on biochemical and hematological parameters in hypercholesterolemic Golden Syrian hamsters
title_fullStr Modulatory effects of rutin on biochemical and hematological parameters in hypercholesterolemic Golden Syrian hamsters
title_full_unstemmed Modulatory effects of rutin on biochemical and hematological parameters in hypercholesterolemic Golden Syrian hamsters
title_sort Modulatory effects of rutin on biochemical and hematological parameters in hypercholesterolemic Golden Syrian hamsters
author Kanashiro,Alexandre
author_facet Kanashiro,Alexandre
Andrade,Daiani C.O.
Kabeya,Luciana M.
Turato,Walter M.
Faccioli,Lucia H.
Uyemura,Sérgio A.
Lucisano-Valim,Yara M.
author_role author
author2 Andrade,Daiani C.O.
Kabeya,Luciana M.
Turato,Walter M.
Faccioli,Lucia H.
Uyemura,Sérgio A.
Lucisano-Valim,Yara M.
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Kanashiro,Alexandre
Andrade,Daiani C.O.
Kabeya,Luciana M.
Turato,Walter M.
Faccioli,Lucia H.
Uyemura,Sérgio A.
Lucisano-Valim,Yara M.
dc.subject.por.fl_str_mv rutin
Golden Syrian hamster
hypercholesterolemia
atherosclerosis
apoptosis
Dimorphandra mollis
topic rutin
Golden Syrian hamster
hypercholesterolemia
atherosclerosis
apoptosis
Dimorphandra mollis
description Flavonoids have been reported to exhibit several pharmacological properties, mainly in cardiovascular and inflammatory diseases. In the present study, we observed that rutin, a known glycosylated flavonoid isolated from Dimorphandra mollis, had a lowering effect on plasma triglyceride levels of diet-induced hypercholesterolemic Golden Syrian hamsters, but did not change total cholesterol and high-density lipoprotein cholesterol levels. Moreover, high-fat or rutin supplemented diets showed no immunotoxic effects, since no significant changes were observed on total white blood cells, granulocytes and mononuclear cells, as well as on the neutrophil apoptosis degree, when compared to untreated animals. Therefore, rutin seems to be a selective and non-toxic modulator of hypercholesterolemia, which can be promising for the development of new drugs.
publishDate 2009
dc.date.none.fl_str_mv 2009-03-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652009000100009
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652009000100009
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0001-37652009000100009
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Ciências
publisher.none.fl_str_mv Academia Brasileira de Ciências
dc.source.none.fl_str_mv Anais da Academia Brasileira de Ciências v.81 n.1 2009
reponame:Anais da Academia Brasileira de Ciências (Online)
instname:Academia Brasileira de Ciências (ABC)
instacron:ABC
instname_str Academia Brasileira de Ciências (ABC)
instacron_str ABC
institution ABC
reponame_str Anais da Academia Brasileira de Ciências (Online)
collection Anais da Academia Brasileira de Ciências (Online)
repository.name.fl_str_mv Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC)
repository.mail.fl_str_mv ||aabc@abc.org.br
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