Chronic granulomatous disease: why an inflammatory disease?

Detalhes bibliográficos
Autor(a) principal: Roxo-Junior,P.
Data de Publicação: 2014
Outros Autores: Simão,H.M.L.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Medical and Biological Research
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2014001100924
Resumo: Chronic granulomatous disease is a primary immunodeficiency caused by mutations in the genes encoding subunits of the phagocytic NADPH oxidase system. Patients can present with severe, recurrent infections and noninfectious conditions. Among the latter, inflammatory manifestations are predominant, especially granulomas and colitis. In this article, we systematically review the possible mechanisms of hyperinflammation in this rare primary immunodeficiency condition and their correlations with clinical aspects.
id ABDC-1_1b7e3e0b657e5de2872317fe71455f90
oai_identifier_str oai:scielo:S0100-879X2014001100924
network_acronym_str ABDC-1
network_name_str Brazilian Journal of Medical and Biological Research
repository_id_str
spelling Chronic granulomatous disease: why an inflammatory disease?Chronic granulomatous diseaseInflammationInfectionGranulomasNADPH oxidaseChronic granulomatous disease is a primary immunodeficiency caused by mutations in the genes encoding subunits of the phagocytic NADPH oxidase system. Patients can present with severe, recurrent infections and noninfectious conditions. Among the latter, inflammatory manifestations are predominant, especially granulomas and colitis. In this article, we systematically review the possible mechanisms of hyperinflammation in this rare primary immunodeficiency condition and their correlations with clinical aspects.Associação Brasileira de Divulgação Científica2014-11-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2014001100924Brazilian Journal of Medical and Biological Research v.47 n.11 2014reponame:Brazilian Journal of Medical and Biological Researchinstname:Associação Brasileira de Divulgação Científica (ABDC)instacron:ABDC10.1590/1414-431X20143735info:eu-repo/semantics/openAccessRoxo-Junior,P.Simão,H.M.L.eng2015-09-04T00:00:00Zoai:scielo:S0100-879X2014001100924Revistahttps://www.bjournal.org/https://old.scielo.br/oai/scielo-oai.phpbjournal@terra.com.br||bjournal@terra.com.br1414-431X0100-879Xopendoar:2015-09-04T00:00Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)false
dc.title.none.fl_str_mv Chronic granulomatous disease: why an inflammatory disease?
title Chronic granulomatous disease: why an inflammatory disease?
spellingShingle Chronic granulomatous disease: why an inflammatory disease?
Roxo-Junior,P.
Chronic granulomatous disease
Inflammation
Infection
Granulomas
NADPH oxidase
title_short Chronic granulomatous disease: why an inflammatory disease?
title_full Chronic granulomatous disease: why an inflammatory disease?
title_fullStr Chronic granulomatous disease: why an inflammatory disease?
title_full_unstemmed Chronic granulomatous disease: why an inflammatory disease?
title_sort Chronic granulomatous disease: why an inflammatory disease?
author Roxo-Junior,P.
author_facet Roxo-Junior,P.
Simão,H.M.L.
author_role author
author2 Simão,H.M.L.
author2_role author
dc.contributor.author.fl_str_mv Roxo-Junior,P.
Simão,H.M.L.
dc.subject.por.fl_str_mv Chronic granulomatous disease
Inflammation
Infection
Granulomas
NADPH oxidase
topic Chronic granulomatous disease
Inflammation
Infection
Granulomas
NADPH oxidase
description Chronic granulomatous disease is a primary immunodeficiency caused by mutations in the genes encoding subunits of the phagocytic NADPH oxidase system. Patients can present with severe, recurrent infections and noninfectious conditions. Among the latter, inflammatory manifestations are predominant, especially granulomas and colitis. In this article, we systematically review the possible mechanisms of hyperinflammation in this rare primary immunodeficiency condition and their correlations with clinical aspects.
publishDate 2014
dc.date.none.fl_str_mv 2014-11-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2014001100924
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2014001100924
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/1414-431X20143735
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
dc.source.none.fl_str_mv Brazilian Journal of Medical and Biological Research v.47 n.11 2014
reponame:Brazilian Journal of Medical and Biological Research
instname:Associação Brasileira de Divulgação Científica (ABDC)
instacron:ABDC
instname_str Associação Brasileira de Divulgação Científica (ABDC)
instacron_str ABDC
institution ABDC
reponame_str Brazilian Journal of Medical and Biological Research
collection Brazilian Journal of Medical and Biological Research
repository.name.fl_str_mv Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)
repository.mail.fl_str_mv bjournal@terra.com.br||bjournal@terra.com.br
_version_ 1754302943377489920

Registros relacionados