Functional role of a specific ganglioside in neuronal migration and neurite outgrowth

Detalhes bibliográficos
Autor(a) principal: Mendez-Otero,R.
Data de Publicação: 2003
Outros Autores: Santiago,M.F.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Medical and Biological Research
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000800006
Resumo: Cell migration occurs extensively during mammalian brain development and persists in a few regions in the adult brain. Defective migratory behavior of neurons is thought to be the underlying cause of several congenital disorders. Knowledge of the dynamics and molecular mechanisms of neuronal movement could expand our understanding of the normal development of the nervous system as well as help decipher the pathogenesis of neurological developmental disorders. In our studies we have identified and characterized a specific ganglioside (9-O-acetyl GD3) localized to the membrane of neurons and glial cells that is expressed in regions of cell migration and neurite outgrowth in the developing and adult rat nervous system. In the present article we review our findings that demonstrate the functional role of this molecule in neuronal motility.
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spelling Functional role of a specific ganglioside in neuronal migration and neurite outgrowthNeuronal migrationGangliosidesDevelopment9-O-acetyl GD3Neurite outgrowthCell migration occurs extensively during mammalian brain development and persists in a few regions in the adult brain. Defective migratory behavior of neurons is thought to be the underlying cause of several congenital disorders. Knowledge of the dynamics and molecular mechanisms of neuronal movement could expand our understanding of the normal development of the nervous system as well as help decipher the pathogenesis of neurological developmental disorders. In our studies we have identified and characterized a specific ganglioside (9-O-acetyl GD3) localized to the membrane of neurons and glial cells that is expressed in regions of cell migration and neurite outgrowth in the developing and adult rat nervous system. In the present article we review our findings that demonstrate the functional role of this molecule in neuronal motility.Associação Brasileira de Divulgação Científica2003-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000800006Brazilian Journal of Medical and Biological Research v.36 n.8 2003reponame:Brazilian Journal of Medical and Biological Researchinstname:Associação Brasileira de Divulgação Científica (ABDC)instacron:ABDC10.1590/S0100-879X2003000800006info:eu-repo/semantics/openAccessMendez-Otero,R.Santiago,M.F.eng2003-07-23T00:00:00Zoai:scielo:S0100-879X2003000800006Revistahttps://www.bjournal.org/https://old.scielo.br/oai/scielo-oai.phpbjournal@terra.com.br||bjournal@terra.com.br1414-431X0100-879Xopendoar:2003-07-23T00:00Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)false
dc.title.none.fl_str_mv Functional role of a specific ganglioside in neuronal migration and neurite outgrowth
title Functional role of a specific ganglioside in neuronal migration and neurite outgrowth
spellingShingle Functional role of a specific ganglioside in neuronal migration and neurite outgrowth
Mendez-Otero,R.
Neuronal migration
Gangliosides
Development
9-O-acetyl GD3
Neurite outgrowth
title_short Functional role of a specific ganglioside in neuronal migration and neurite outgrowth
title_full Functional role of a specific ganglioside in neuronal migration and neurite outgrowth
title_fullStr Functional role of a specific ganglioside in neuronal migration and neurite outgrowth
title_full_unstemmed Functional role of a specific ganglioside in neuronal migration and neurite outgrowth
title_sort Functional role of a specific ganglioside in neuronal migration and neurite outgrowth
author Mendez-Otero,R.
author_facet Mendez-Otero,R.
Santiago,M.F.
author_role author
author2 Santiago,M.F.
author2_role author
dc.contributor.author.fl_str_mv Mendez-Otero,R.
Santiago,M.F.
dc.subject.por.fl_str_mv Neuronal migration
Gangliosides
Development
9-O-acetyl GD3
Neurite outgrowth
topic Neuronal migration
Gangliosides
Development
9-O-acetyl GD3
Neurite outgrowth
description Cell migration occurs extensively during mammalian brain development and persists in a few regions in the adult brain. Defective migratory behavior of neurons is thought to be the underlying cause of several congenital disorders. Knowledge of the dynamics and molecular mechanisms of neuronal movement could expand our understanding of the normal development of the nervous system as well as help decipher the pathogenesis of neurological developmental disorders. In our studies we have identified and characterized a specific ganglioside (9-O-acetyl GD3) localized to the membrane of neurons and glial cells that is expressed in regions of cell migration and neurite outgrowth in the developing and adult rat nervous system. In the present article we review our findings that demonstrate the functional role of this molecule in neuronal motility.
publishDate 2003
dc.date.none.fl_str_mv 2003-08-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000800006
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000800006
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0100-879X2003000800006
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
dc.source.none.fl_str_mv Brazilian Journal of Medical and Biological Research v.36 n.8 2003
reponame:Brazilian Journal of Medical and Biological Research
instname:Associação Brasileira de Divulgação Científica (ABDC)
instacron:ABDC
instname_str Associação Brasileira de Divulgação Científica (ABDC)
instacron_str ABDC
institution ABDC
reponame_str Brazilian Journal of Medical and Biological Research
collection Brazilian Journal of Medical and Biological Research
repository.name.fl_str_mv Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)
repository.mail.fl_str_mv bjournal@terra.com.br||bjournal@terra.com.br
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