Adipose tissue is less responsive to food restriction anti-inflammatory effects than liver, muscle, and brain in mice
Autor(a) principal: | |
---|---|
Data de Publicação: | 2019 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Medical and Biological Research |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019000100612 |
Resumo: | High caloric intake promotes chronic inflammation, insulin resistance, and chronic diseases such as type-2 diabetes, which may be prevented by food restriction (FR). The effect of FR on expression of pro-inflammatory and anti-inflammatory genes in adipose tissue, liver, muscle, and brain was compared. Male Swiss mice were submitted to FR (FR group) or had free access to food (control group) during 56 days. The liver, gastrocnemius muscle, brain, and epididymal white adipose tissue (WAT) were collected for analysis of gene expressions. FR attenuated inflammation in the liver, brain, and gastrocnemius muscle but did not markedly change inflammatory gene expression in epididymal WAT. We concluded that adipose tissue was less responsive to FR in terms of gene expression of pro-inflammatory and anti-inflammatory genes. |
id |
ABDC-1_2d437c92791127ee7d117b8d65eae6c8 |
---|---|
oai_identifier_str |
oai:scielo:S0100-879X2019000100612 |
network_acronym_str |
ABDC-1 |
network_name_str |
Brazilian Journal of Medical and Biological Research |
repository_id_str |
|
spelling |
Adipose tissue is less responsive to food restriction anti-inflammatory effects than liver, muscle, and brain in miceCaloric restrictionPro-inflammatory cytokinesAnti-inflammatory cytokinesAcetyl-CoA carboxylaseDisease preventionHigh caloric intake promotes chronic inflammation, insulin resistance, and chronic diseases such as type-2 diabetes, which may be prevented by food restriction (FR). The effect of FR on expression of pro-inflammatory and anti-inflammatory genes in adipose tissue, liver, muscle, and brain was compared. Male Swiss mice were submitted to FR (FR group) or had free access to food (control group) during 56 days. The liver, gastrocnemius muscle, brain, and epididymal white adipose tissue (WAT) were collected for analysis of gene expressions. FR attenuated inflammation in the liver, brain, and gastrocnemius muscle but did not markedly change inflammatory gene expression in epididymal WAT. We concluded that adipose tissue was less responsive to FR in terms of gene expression of pro-inflammatory and anti-inflammatory genes.Associação Brasileira de Divulgação Científica2019-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019000100612Brazilian Journal of Medical and Biological Research v.52 n.1 2019reponame:Brazilian Journal of Medical and Biological Researchinstname:Associação Brasileira de Divulgação Científica (ABDC)instacron:ABDC10.1590/1414-431x20188150info:eu-repo/semantics/openAccessAntunes,M.M.de Almeida-Souza,C.B.Godoy,G.Crisma,A.R.Masi,L.N.Curi,R.Bazotte,R.B.eng2019-03-19T00:00:00Zoai:scielo:S0100-879X2019000100612Revistahttps://www.bjournal.org/https://old.scielo.br/oai/scielo-oai.phpbjournal@terra.com.br||bjournal@terra.com.br1414-431X0100-879Xopendoar:2019-03-19T00:00Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)false |
dc.title.none.fl_str_mv |
Adipose tissue is less responsive to food restriction anti-inflammatory effects than liver, muscle, and brain in mice |
title |
Adipose tissue is less responsive to food restriction anti-inflammatory effects than liver, muscle, and brain in mice |
spellingShingle |
Adipose tissue is less responsive to food restriction anti-inflammatory effects than liver, muscle, and brain in mice Antunes,M.M. Caloric restriction Pro-inflammatory cytokines Anti-inflammatory cytokines Acetyl-CoA carboxylase Disease prevention |
title_short |
Adipose tissue is less responsive to food restriction anti-inflammatory effects than liver, muscle, and brain in mice |
title_full |
Adipose tissue is less responsive to food restriction anti-inflammatory effects than liver, muscle, and brain in mice |
title_fullStr |
Adipose tissue is less responsive to food restriction anti-inflammatory effects than liver, muscle, and brain in mice |
title_full_unstemmed |
Adipose tissue is less responsive to food restriction anti-inflammatory effects than liver, muscle, and brain in mice |
title_sort |
Adipose tissue is less responsive to food restriction anti-inflammatory effects than liver, muscle, and brain in mice |
author |
Antunes,M.M. |
author_facet |
Antunes,M.M. de Almeida-Souza,C.B. Godoy,G. Crisma,A.R. Masi,L.N. Curi,R. Bazotte,R.B. |
author_role |
author |
author2 |
de Almeida-Souza,C.B. Godoy,G. Crisma,A.R. Masi,L.N. Curi,R. Bazotte,R.B. |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Antunes,M.M. de Almeida-Souza,C.B. Godoy,G. Crisma,A.R. Masi,L.N. Curi,R. Bazotte,R.B. |
dc.subject.por.fl_str_mv |
Caloric restriction Pro-inflammatory cytokines Anti-inflammatory cytokines Acetyl-CoA carboxylase Disease prevention |
topic |
Caloric restriction Pro-inflammatory cytokines Anti-inflammatory cytokines Acetyl-CoA carboxylase Disease prevention |
description |
High caloric intake promotes chronic inflammation, insulin resistance, and chronic diseases such as type-2 diabetes, which may be prevented by food restriction (FR). The effect of FR on expression of pro-inflammatory and anti-inflammatory genes in adipose tissue, liver, muscle, and brain was compared. Male Swiss mice were submitted to FR (FR group) or had free access to food (control group) during 56 days. The liver, gastrocnemius muscle, brain, and epididymal white adipose tissue (WAT) were collected for analysis of gene expressions. FR attenuated inflammation in the liver, brain, and gastrocnemius muscle but did not markedly change inflammatory gene expression in epididymal WAT. We concluded that adipose tissue was less responsive to FR in terms of gene expression of pro-inflammatory and anti-inflammatory genes. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019000100612 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019000100612 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1414-431x20188150 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
dc.source.none.fl_str_mv |
Brazilian Journal of Medical and Biological Research v.52 n.1 2019 reponame:Brazilian Journal of Medical and Biological Research instname:Associação Brasileira de Divulgação Científica (ABDC) instacron:ABDC |
instname_str |
Associação Brasileira de Divulgação Científica (ABDC) |
instacron_str |
ABDC |
institution |
ABDC |
reponame_str |
Brazilian Journal of Medical and Biological Research |
collection |
Brazilian Journal of Medical and Biological Research |
repository.name.fl_str_mv |
Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC) |
repository.mail.fl_str_mv |
bjournal@terra.com.br||bjournal@terra.com.br |
_version_ |
1754302946825207808 |