Anticonvulsant and proconvulsant roles of nitric oxide in experimental epilepsy models
Autor(a) principal: | |
---|---|
Data de Publicação: | 1997 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Medical and Biological Research |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997000800010 |
Resumo: | The effect of acute (120 mg/kg) and chronic (25 mg/kg, twice a day, for 4 days) intraperitonial injection of the nitric oxide (NO) synthase (NOS) inhibitor NG-nitro-L-arginine (L-NOARG) was evaluated on seizure induction by drugs such as pilocarpine and pentylenetetrazole (PTZ) and by sound stimulation of audiogenic seizure-resistant (R) and audiogenic seizure-susceptible (S) rats. Seizures were elicited by a subconvulsant dose of pilocarpine (100 mg/kg) only after NOS inhibition. NOS inhibition also simultaneously potentiated the severity of PTZ-induced limbic seizures (60 mg/kg) and protected against PTZ-induced tonic seizures (80 mg/kg). The audiogenic seizure susceptibility of S or R rats did not change after similar treatments. In conclusion, proconvulsant effects of NOS inhibition are suggested to occur in the pilocarpine model and in the limbic components of PTZ-induced seizures, while an anticonvulsant role is suggested for the tonic seizures induced by higher doses of PTZ, revealing inhibitor-specific interactions with convulsant dose and also confirming the hypothesis that the effects of NOS inhibitors vary with the model of seizure |
id |
ABDC-1_41508c2653bc2d38a11e56cf6c3209a3 |
---|---|
oai_identifier_str |
oai:scielo:S0100-879X1997000800010 |
network_acronym_str |
ABDC-1 |
network_name_str |
Brazilian Journal of Medical and Biological Research |
repository_id_str |
|
spelling |
Anticonvulsant and proconvulsant roles of nitric oxide in experimental epilepsy modelsexperimental epilepsyseizuresforebrainbrainstempilocarpinepentylenetetrazolaudiogenic seizuresgenetically epilepsy-prone ratsGEPRnitric oxideThe effect of acute (120 mg/kg) and chronic (25 mg/kg, twice a day, for 4 days) intraperitonial injection of the nitric oxide (NO) synthase (NOS) inhibitor NG-nitro-L-arginine (L-NOARG) was evaluated on seizure induction by drugs such as pilocarpine and pentylenetetrazole (PTZ) and by sound stimulation of audiogenic seizure-resistant (R) and audiogenic seizure-susceptible (S) rats. Seizures were elicited by a subconvulsant dose of pilocarpine (100 mg/kg) only after NOS inhibition. NOS inhibition also simultaneously potentiated the severity of PTZ-induced limbic seizures (60 mg/kg) and protected against PTZ-induced tonic seizures (80 mg/kg). The audiogenic seizure susceptibility of S or R rats did not change after similar treatments. In conclusion, proconvulsant effects of NOS inhibition are suggested to occur in the pilocarpine model and in the limbic components of PTZ-induced seizures, while an anticonvulsant role is suggested for the tonic seizures induced by higher doses of PTZ, revealing inhibitor-specific interactions with convulsant dose and also confirming the hypothesis that the effects of NOS inhibitors vary with the model of seizureAssociação Brasileira de Divulgação Científica1997-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997000800010Brazilian Journal of Medical and Biological Research v.30 n.8 1997reponame:Brazilian Journal of Medical and Biological Researchinstname:Associação Brasileira de Divulgação Científica (ABDC)instacron:ABDC10.1590/S0100-879X1997000800010info:eu-repo/semantics/openAccessDel-Bel,E.A.Oliveira,P.R.Oliveira,J.A.C.Mishra,P.K.Jobe,P.C.Garcia-Cairasco,N.eng1998-10-07T00:00:00Zoai:scielo:S0100-879X1997000800010Revistahttps://www.bjournal.org/https://old.scielo.br/oai/scielo-oai.phpbjournal@terra.com.br||bjournal@terra.com.br1414-431X0100-879Xopendoar:1998-10-07T00:00Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)false |
dc.title.none.fl_str_mv |
Anticonvulsant and proconvulsant roles of nitric oxide in experimental epilepsy models |
title |
Anticonvulsant and proconvulsant roles of nitric oxide in experimental epilepsy models |
spellingShingle |
Anticonvulsant and proconvulsant roles of nitric oxide in experimental epilepsy models Del-Bel,E.A. experimental epilepsy seizures forebrain brainstem pilocarpine pentylenetetrazol audiogenic seizures genetically epilepsy-prone rats GEPR nitric oxide |
title_short |
Anticonvulsant and proconvulsant roles of nitric oxide in experimental epilepsy models |
title_full |
Anticonvulsant and proconvulsant roles of nitric oxide in experimental epilepsy models |
title_fullStr |
Anticonvulsant and proconvulsant roles of nitric oxide in experimental epilepsy models |
title_full_unstemmed |
Anticonvulsant and proconvulsant roles of nitric oxide in experimental epilepsy models |
title_sort |
Anticonvulsant and proconvulsant roles of nitric oxide in experimental epilepsy models |
author |
Del-Bel,E.A. |
author_facet |
Del-Bel,E.A. Oliveira,P.R. Oliveira,J.A.C. Mishra,P.K. Jobe,P.C. Garcia-Cairasco,N. |
author_role |
author |
author2 |
Oliveira,P.R. Oliveira,J.A.C. Mishra,P.K. Jobe,P.C. Garcia-Cairasco,N. |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Del-Bel,E.A. Oliveira,P.R. Oliveira,J.A.C. Mishra,P.K. Jobe,P.C. Garcia-Cairasco,N. |
dc.subject.por.fl_str_mv |
experimental epilepsy seizures forebrain brainstem pilocarpine pentylenetetrazol audiogenic seizures genetically epilepsy-prone rats GEPR nitric oxide |
topic |
experimental epilepsy seizures forebrain brainstem pilocarpine pentylenetetrazol audiogenic seizures genetically epilepsy-prone rats GEPR nitric oxide |
description |
The effect of acute (120 mg/kg) and chronic (25 mg/kg, twice a day, for 4 days) intraperitonial injection of the nitric oxide (NO) synthase (NOS) inhibitor NG-nitro-L-arginine (L-NOARG) was evaluated on seizure induction by drugs such as pilocarpine and pentylenetetrazole (PTZ) and by sound stimulation of audiogenic seizure-resistant (R) and audiogenic seizure-susceptible (S) rats. Seizures were elicited by a subconvulsant dose of pilocarpine (100 mg/kg) only after NOS inhibition. NOS inhibition also simultaneously potentiated the severity of PTZ-induced limbic seizures (60 mg/kg) and protected against PTZ-induced tonic seizures (80 mg/kg). The audiogenic seizure susceptibility of S or R rats did not change after similar treatments. In conclusion, proconvulsant effects of NOS inhibition are suggested to occur in the pilocarpine model and in the limbic components of PTZ-induced seizures, while an anticonvulsant role is suggested for the tonic seizures induced by higher doses of PTZ, revealing inhibitor-specific interactions with convulsant dose and also confirming the hypothesis that the effects of NOS inhibitors vary with the model of seizure |
publishDate |
1997 |
dc.date.none.fl_str_mv |
1997-08-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997000800010 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997000800010 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0100-879X1997000800010 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
dc.source.none.fl_str_mv |
Brazilian Journal of Medical and Biological Research v.30 n.8 1997 reponame:Brazilian Journal of Medical and Biological Research instname:Associação Brasileira de Divulgação Científica (ABDC) instacron:ABDC |
instname_str |
Associação Brasileira de Divulgação Científica (ABDC) |
instacron_str |
ABDC |
institution |
ABDC |
reponame_str |
Brazilian Journal of Medical and Biological Research |
collection |
Brazilian Journal of Medical and Biological Research |
repository.name.fl_str_mv |
Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC) |
repository.mail.fl_str_mv |
bjournal@terra.com.br||bjournal@terra.com.br |
_version_ |
1754302928778166272 |