High prevalence of the GSTM3*A/B polymorphism in sub-Sarahan African populations
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Medical and Biological Research |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000700010 |
Resumo: | A 3-bp insertion/deletion polymorphism in intron 6 of GSTM3 (rs1799735, GSTM3*A/*B) affects the activity of the phase 2 xenobiotic metabolizing enzyme GSTM3 and has been associated with increased cancer risk. The GSTM3*B allele is rare or absent in Southeast Asians, occurs in 5-20% of Europeans but was detected in 80% of Bantu from South Africa. The wide genetic diversity among Africans led us to investigate whether the high frequency of GSTM3*B prevailed in other sub-Saharan African populations. In 168 healthy individuals from Angola, Mozambique and the São Tomé e Príncipe islands, the GSTM3*B allele was three times more frequent (0.74-0.78) than the GSTM3*A allele (0.22-0.26), with no significant differences in allele frequency across the three groups. We combined these data with previously published results to carry out a multidimensional scaling analysis, which provided a visualization of the worldwide population affinities based on the GSTM3 *A/*B polymorphism. |
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Brazilian Journal of Medical and Biological Research |
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High prevalence of the GSTM3*A/B polymorphism in sub-Sarahan African populationsAfrican populationsGSTM3 polymorphismsMultidimensional scaling analysisPharmacogeneticsPopulation diversityA 3-bp insertion/deletion polymorphism in intron 6 of GSTM3 (rs1799735, GSTM3*A/*B) affects the activity of the phase 2 xenobiotic metabolizing enzyme GSTM3 and has been associated with increased cancer risk. The GSTM3*B allele is rare or absent in Southeast Asians, occurs in 5-20% of Europeans but was detected in 80% of Bantu from South Africa. The wide genetic diversity among Africans led us to investigate whether the high frequency of GSTM3*B prevailed in other sub-Saharan African populations. In 168 healthy individuals from Angola, Mozambique and the São Tomé e Príncipe islands, the GSTM3*B allele was three times more frequent (0.74-0.78) than the GSTM3*A allele (0.22-0.26), with no significant differences in allele frequency across the three groups. We combined these data with previously published results to carry out a multidimensional scaling analysis, which provided a visualization of the worldwide population affinities based on the GSTM3 *A/*B polymorphism.Associação Brasileira de Divulgação Científica2010-07-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000700010Brazilian Journal of Medical and Biological Research v.43 n.7 2010reponame:Brazilian Journal of Medical and Biological Researchinstname:Associação Brasileira de Divulgação Científica (ABDC)instacron:ABDC10.1590/S0100-879X2010007500056info:eu-repo/semantics/openAccessTeixeira,D.Vargens,D.Príncipe,A.Oliveira,E.Amorim,A.Prata,M.J.Suarez-Kurtz,G.eng2010-07-02T00:00:00Zoai:scielo:S0100-879X2010000700010Revistahttps://www.bjournal.org/https://old.scielo.br/oai/scielo-oai.phpbjournal@terra.com.br||bjournal@terra.com.br1414-431X0100-879Xopendoar:2010-07-02T00:00Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)false |
dc.title.none.fl_str_mv |
High prevalence of the GSTM3*A/B polymorphism in sub-Sarahan African populations |
title |
High prevalence of the GSTM3*A/B polymorphism in sub-Sarahan African populations |
spellingShingle |
High prevalence of the GSTM3*A/B polymorphism in sub-Sarahan African populations Teixeira,D. African populations GSTM3 polymorphisms Multidimensional scaling analysis Pharmacogenetics Population diversity |
title_short |
High prevalence of the GSTM3*A/B polymorphism in sub-Sarahan African populations |
title_full |
High prevalence of the GSTM3*A/B polymorphism in sub-Sarahan African populations |
title_fullStr |
High prevalence of the GSTM3*A/B polymorphism in sub-Sarahan African populations |
title_full_unstemmed |
High prevalence of the GSTM3*A/B polymorphism in sub-Sarahan African populations |
title_sort |
High prevalence of the GSTM3*A/B polymorphism in sub-Sarahan African populations |
author |
Teixeira,D. |
author_facet |
Teixeira,D. Vargens,D. Príncipe,A. Oliveira,E. Amorim,A. Prata,M.J. Suarez-Kurtz,G. |
author_role |
author |
author2 |
Vargens,D. Príncipe,A. Oliveira,E. Amorim,A. Prata,M.J. Suarez-Kurtz,G. |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Teixeira,D. Vargens,D. Príncipe,A. Oliveira,E. Amorim,A. Prata,M.J. Suarez-Kurtz,G. |
dc.subject.por.fl_str_mv |
African populations GSTM3 polymorphisms Multidimensional scaling analysis Pharmacogenetics Population diversity |
topic |
African populations GSTM3 polymorphisms Multidimensional scaling analysis Pharmacogenetics Population diversity |
description |
A 3-bp insertion/deletion polymorphism in intron 6 of GSTM3 (rs1799735, GSTM3*A/*B) affects the activity of the phase 2 xenobiotic metabolizing enzyme GSTM3 and has been associated with increased cancer risk. The GSTM3*B allele is rare or absent in Southeast Asians, occurs in 5-20% of Europeans but was detected in 80% of Bantu from South Africa. The wide genetic diversity among Africans led us to investigate whether the high frequency of GSTM3*B prevailed in other sub-Saharan African populations. In 168 healthy individuals from Angola, Mozambique and the São Tomé e Príncipe islands, the GSTM3*B allele was three times more frequent (0.74-0.78) than the GSTM3*A allele (0.22-0.26), with no significant differences in allele frequency across the three groups. We combined these data with previously published results to carry out a multidimensional scaling analysis, which provided a visualization of the worldwide population affinities based on the GSTM3 *A/*B polymorphism. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-07-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000700010 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000700010 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0100-879X2010007500056 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
dc.source.none.fl_str_mv |
Brazilian Journal of Medical and Biological Research v.43 n.7 2010 reponame:Brazilian Journal of Medical and Biological Research instname:Associação Brasileira de Divulgação Científica (ABDC) instacron:ABDC |
instname_str |
Associação Brasileira de Divulgação Científica (ABDC) |
instacron_str |
ABDC |
institution |
ABDC |
reponame_str |
Brazilian Journal of Medical and Biological Research |
collection |
Brazilian Journal of Medical and Biological Research |
repository.name.fl_str_mv |
Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC) |
repository.mail.fl_str_mv |
bjournal@terra.com.br||bjournal@terra.com.br |
_version_ |
1754302938930479104 |