Regulation of the renal proximal tubule second sodium pump by angiotensins

• Autor(a) principal: Caruso-Neves,C.
• Data de Publicação: 2001
• Outros Autores: Rangel,L.B.A., Lara,L.S., Lopes,A.G.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Brazilian Journal of Medical and Biological Research
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000800015
• topic: Na+-ATPase; angiotensin II; angiotensin-(1-7); furosemide; proximal tubule

For several years it was believed that angiotensin II (Ang II) alone mediated the effects of the renin-angiotensin system. However, it has been observed that other peptides of this system, such as angiotensin-(1-7) (Ang-(1-7)), present biological activity. The effect of Ang II and Ang-(1-7) on renal sodium excretion has been associated, at least in part, with modulation of proximal tubule sodium reabsorption. In the present review, we discuss the evidence for the involvement of Na+-ATPase, called the second sodium pump, as a target for the actions of these compounds in the regulation of proximal tubule sodium reabsorption.