Biophysical characteristics of gap junctions in vascular wall cells: implications for vascular biology and disease

Detalhes bibliográficos
Autor(a) principal: Brink,P.R.
Data de Publicação: 2000
Outros Autores: Ricotta,J., Christ,G.J.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Medical and Biological Research
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000400007
Resumo: The role gap junction channels play in the normal and abnormal functioning of the vascular wall is the subject of much research. The biophysical properties of gap junctions are an essential component in understanding how gap junctions function to allow coordinated relaxation and contraction of vascular smooth muscle. This study reviews the properties thus far elucidated and relates those properties to tissue function. We ask how biophysical and structural properties such as gating, permselectivity, subconductive states and channel type (heteromeric vs homotypic vs heterotypic) might affect vascular smooth muscle tone.
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spelling Biophysical characteristics of gap junctions in vascular wall cells: implications for vascular biology and diseasevascular smooth musclegap junctionsThe role gap junction channels play in the normal and abnormal functioning of the vascular wall is the subject of much research. The biophysical properties of gap junctions are an essential component in understanding how gap junctions function to allow coordinated relaxation and contraction of vascular smooth muscle. This study reviews the properties thus far elucidated and relates those properties to tissue function. We ask how biophysical and structural properties such as gating, permselectivity, subconductive states and channel type (heteromeric vs homotypic vs heterotypic) might affect vascular smooth muscle tone.Associação Brasileira de Divulgação Científica2000-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000400007Brazilian Journal of Medical and Biological Research v.33 n.4 2000reponame:Brazilian Journal of Medical and Biological Researchinstname:Associação Brasileira de Divulgação Científica (ABDC)instacron:ABDC10.1590/S0100-879X2000000400007info:eu-repo/semantics/openAccessBrink,P.R.Ricotta,J.Christ,G.J.eng2000-03-30T00:00:00Zoai:scielo:S0100-879X2000000400007Revistahttps://www.bjournal.org/https://old.scielo.br/oai/scielo-oai.phpbjournal@terra.com.br||bjournal@terra.com.br1414-431X0100-879Xopendoar:2000-03-30T00:00Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)false
dc.title.none.fl_str_mv Biophysical characteristics of gap junctions in vascular wall cells: implications for vascular biology and disease
title Biophysical characteristics of gap junctions in vascular wall cells: implications for vascular biology and disease
spellingShingle Biophysical characteristics of gap junctions in vascular wall cells: implications for vascular biology and disease
Brink,P.R.
vascular smooth muscle
gap junctions
title_short Biophysical characteristics of gap junctions in vascular wall cells: implications for vascular biology and disease
title_full Biophysical characteristics of gap junctions in vascular wall cells: implications for vascular biology and disease
title_fullStr Biophysical characteristics of gap junctions in vascular wall cells: implications for vascular biology and disease
title_full_unstemmed Biophysical characteristics of gap junctions in vascular wall cells: implications for vascular biology and disease
title_sort Biophysical characteristics of gap junctions in vascular wall cells: implications for vascular biology and disease
author Brink,P.R.
author_facet Brink,P.R.
Ricotta,J.
Christ,G.J.
author_role author
author2 Ricotta,J.
Christ,G.J.
author2_role author
author
dc.contributor.author.fl_str_mv Brink,P.R.
Ricotta,J.
Christ,G.J.
dc.subject.por.fl_str_mv vascular smooth muscle
gap junctions
topic vascular smooth muscle
gap junctions
description The role gap junction channels play in the normal and abnormal functioning of the vascular wall is the subject of much research. The biophysical properties of gap junctions are an essential component in understanding how gap junctions function to allow coordinated relaxation and contraction of vascular smooth muscle. This study reviews the properties thus far elucidated and relates those properties to tissue function. We ask how biophysical and structural properties such as gating, permselectivity, subconductive states and channel type (heteromeric vs homotypic vs heterotypic) might affect vascular smooth muscle tone.
publishDate 2000
dc.date.none.fl_str_mv 2000-04-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000400007
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000400007
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0100-879X2000000400007
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
dc.source.none.fl_str_mv Brazilian Journal of Medical and Biological Research v.33 n.4 2000
reponame:Brazilian Journal of Medical and Biological Research
instname:Associação Brasileira de Divulgação Científica (ABDC)
instacron:ABDC
instname_str Associação Brasileira de Divulgação Científica (ABDC)
instacron_str ABDC
institution ABDC
reponame_str Brazilian Journal of Medical and Biological Research
collection Brazilian Journal of Medical and Biological Research
repository.name.fl_str_mv Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)
repository.mail.fl_str_mv bjournal@terra.com.br||bjournal@terra.com.br
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