Evaluation of factors for predicting risk of uveitis recurrence in Behcet's disease patients
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Medical and Biological Research |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2020000600608 |
Resumo: | This study aimed to investigate the predictive factors for uveitis recurrence (UR) risk in Behcet's disease (BD) patients. BD patients (n=164) with a history of uveitis were recruited, and demographic data, clinical features, and laboratory tests were recorded. Uveitis was defined as anterior uveitis, intermediate uveitis, posterior uveitis, panuveitis referring to the “International Uveitis Study Group recommendations for the evaluation of intraocular inflammatory disease”. In total, there were 70 UR patients and 94 non-UR patients. Compared to non-UR patients, UR patients appeared to be older and presented with increased uveitis occurrence rate and times within 3 months, oral ulcers occurrence rate, as well as higher concentrations of triglycerides (TG), total cholesterol (TC), low-density lipoprotein (LDL), and serum amyloid A (SAA). Multivariate logistic model disclosed that uveitis occurrence times within 3 months, oral ulcers, TG, LDL, and SAA independently predicted higher risk of UR. Furthermore, receiver operating characteristic curve analysis showed that the combination of uveitis occurrence times within 3 months, oral ulcers, TG, LDL, and SAA exhibited a high predictive value for UR risk with an area under the curve of 0.983 (95%CI: 0.969−0.998). In conclusion, uveitis occurrence times within 3 months, oral ulcers, TG, LDL, and SAA might be potential predictive factors for UR risk in BD patients, which can help in prevention and management of the disease. |
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Brazilian Journal of Medical and Biological Research |
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Evaluation of factors for predicting risk of uveitis recurrence in Behcet's disease patientsAnterior uveitis recurrenceBehcet’s diseaseOral ulcersTriglyceridesLow-density lipoproteinSerum amyloid AThis study aimed to investigate the predictive factors for uveitis recurrence (UR) risk in Behcet's disease (BD) patients. BD patients (n=164) with a history of uveitis were recruited, and demographic data, clinical features, and laboratory tests were recorded. Uveitis was defined as anterior uveitis, intermediate uveitis, posterior uveitis, panuveitis referring to the “International Uveitis Study Group recommendations for the evaluation of intraocular inflammatory disease”. In total, there were 70 UR patients and 94 non-UR patients. Compared to non-UR patients, UR patients appeared to be older and presented with increased uveitis occurrence rate and times within 3 months, oral ulcers occurrence rate, as well as higher concentrations of triglycerides (TG), total cholesterol (TC), low-density lipoprotein (LDL), and serum amyloid A (SAA). Multivariate logistic model disclosed that uveitis occurrence times within 3 months, oral ulcers, TG, LDL, and SAA independently predicted higher risk of UR. Furthermore, receiver operating characteristic curve analysis showed that the combination of uveitis occurrence times within 3 months, oral ulcers, TG, LDL, and SAA exhibited a high predictive value for UR risk with an area under the curve of 0.983 (95%CI: 0.969−0.998). In conclusion, uveitis occurrence times within 3 months, oral ulcers, TG, LDL, and SAA might be potential predictive factors for UR risk in BD patients, which can help in prevention and management of the disease.Associação Brasileira de Divulgação Científica2020-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2020000600608Brazilian Journal of Medical and Biological Research v.53 n.6 2020reponame:Brazilian Journal of Medical and Biological Researchinstname:Associação Brasileira de Divulgação Científica (ABDC)instacron:ABDC10.1590/1414-431x20209118info:eu-repo/semantics/openAccessCai,JianfeiQi,LinChen,YongZou,JunShen,YanLuo,DanBao,HuafangYe,JingfenMa,HaifenGuan,Jian-Longeng2020-04-30T00:00:00Zoai:scielo:S0100-879X2020000600608Revistahttps://www.bjournal.org/https://old.scielo.br/oai/scielo-oai.phpbjournal@terra.com.br||bjournal@terra.com.br1414-431X0100-879Xopendoar:2020-04-30T00:00Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)false |
dc.title.none.fl_str_mv |
Evaluation of factors for predicting risk of uveitis recurrence in Behcet's disease patients |
title |
Evaluation of factors for predicting risk of uveitis recurrence in Behcet's disease patients |
spellingShingle |
Evaluation of factors for predicting risk of uveitis recurrence in Behcet's disease patients Cai,Jianfei Anterior uveitis recurrence Behcet’s disease Oral ulcers Triglycerides Low-density lipoprotein Serum amyloid A |
title_short |
Evaluation of factors for predicting risk of uveitis recurrence in Behcet's disease patients |
title_full |
Evaluation of factors for predicting risk of uveitis recurrence in Behcet's disease patients |
title_fullStr |
Evaluation of factors for predicting risk of uveitis recurrence in Behcet's disease patients |
title_full_unstemmed |
Evaluation of factors for predicting risk of uveitis recurrence in Behcet's disease patients |
title_sort |
Evaluation of factors for predicting risk of uveitis recurrence in Behcet's disease patients |
author |
Cai,Jianfei |
author_facet |
Cai,Jianfei Qi,Lin Chen,Yong Zou,Jun Shen,Yan Luo,Dan Bao,Huafang Ye,Jingfen Ma,Haifen Guan,Jian-Long |
author_role |
author |
author2 |
Qi,Lin Chen,Yong Zou,Jun Shen,Yan Luo,Dan Bao,Huafang Ye,Jingfen Ma,Haifen Guan,Jian-Long |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Cai,Jianfei Qi,Lin Chen,Yong Zou,Jun Shen,Yan Luo,Dan Bao,Huafang Ye,Jingfen Ma,Haifen Guan,Jian-Long |
dc.subject.por.fl_str_mv |
Anterior uveitis recurrence Behcet’s disease Oral ulcers Triglycerides Low-density lipoprotein Serum amyloid A |
topic |
Anterior uveitis recurrence Behcet’s disease Oral ulcers Triglycerides Low-density lipoprotein Serum amyloid A |
description |
This study aimed to investigate the predictive factors for uveitis recurrence (UR) risk in Behcet's disease (BD) patients. BD patients (n=164) with a history of uveitis were recruited, and demographic data, clinical features, and laboratory tests were recorded. Uveitis was defined as anterior uveitis, intermediate uveitis, posterior uveitis, panuveitis referring to the “International Uveitis Study Group recommendations for the evaluation of intraocular inflammatory disease”. In total, there were 70 UR patients and 94 non-UR patients. Compared to non-UR patients, UR patients appeared to be older and presented with increased uveitis occurrence rate and times within 3 months, oral ulcers occurrence rate, as well as higher concentrations of triglycerides (TG), total cholesterol (TC), low-density lipoprotein (LDL), and serum amyloid A (SAA). Multivariate logistic model disclosed that uveitis occurrence times within 3 months, oral ulcers, TG, LDL, and SAA independently predicted higher risk of UR. Furthermore, receiver operating characteristic curve analysis showed that the combination of uveitis occurrence times within 3 months, oral ulcers, TG, LDL, and SAA exhibited a high predictive value for UR risk with an area under the curve of 0.983 (95%CI: 0.969−0.998). In conclusion, uveitis occurrence times within 3 months, oral ulcers, TG, LDL, and SAA might be potential predictive factors for UR risk in BD patients, which can help in prevention and management of the disease. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2020000600608 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2020000600608 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1414-431x20209118 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
dc.source.none.fl_str_mv |
Brazilian Journal of Medical and Biological Research v.53 n.6 2020 reponame:Brazilian Journal of Medical and Biological Research instname:Associação Brasileira de Divulgação Científica (ABDC) instacron:ABDC |
instname_str |
Associação Brasileira de Divulgação Científica (ABDC) |
instacron_str |
ABDC |
institution |
ABDC |
reponame_str |
Brazilian Journal of Medical and Biological Research |
collection |
Brazilian Journal of Medical and Biological Research |
repository.name.fl_str_mv |
Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC) |
repository.mail.fl_str_mv |
bjournal@terra.com.br||bjournal@terra.com.br |
_version_ |
1754302947651485696 |