A novel stem cell therapy for hepatitis B virus-related acute-on-chronic liver failure
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Medical and Biological Research |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2020001100613 |
Resumo: | The aim of this study was to propose a stem cell therapy for hepatitis B virus (HBV)-related acute-on-chronic liver failure (ACLF) based on plasma exchange (PE) for peripheral blood stem cell (PBSC) collection and examine its safety and efficacy. Sixty patients (n=20 in each group) were randomized to PE (PE alone), granulocyte colony-stimulating factor (G-CSF) (PE after G-CSF treatment), and PBSC transplantation (PBSCT) (G-CSF, PE, PBSC collection and hepatic artery injection) groups. Patients were followed-up for 24 weeks. Liver function and adverse events were recorded. Survival analysis was performed. PBSCT improved blood ammonia levels at 1 week (P<0.05). The level of total bilirubin, international normalized ratio, and creatinine showed significant differences in the 4th week of treatment (P<0.05). The survival rates of the PE, G-CSF, and PBSCT groups were 50, 65, and 85% at 90 days (P=0.034). There was a significant difference in 90-day survival between the PE and PBSCT groups (P=0.021). The preliminary results suggested that PBSCT was safe, with a possibility of improved 90-day survival in patients with HBV-ACLF. |
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Brazilian Journal of Medical and Biological Research |
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A novel stem cell therapy for hepatitis B virus-related acute-on-chronic liver failureStem cell transplantationHepatic artery transfusionAcute-on-chronic liver failureHepatitis B virusRandomized controlled trialThe aim of this study was to propose a stem cell therapy for hepatitis B virus (HBV)-related acute-on-chronic liver failure (ACLF) based on plasma exchange (PE) for peripheral blood stem cell (PBSC) collection and examine its safety and efficacy. Sixty patients (n=20 in each group) were randomized to PE (PE alone), granulocyte colony-stimulating factor (G-CSF) (PE after G-CSF treatment), and PBSC transplantation (PBSCT) (G-CSF, PE, PBSC collection and hepatic artery injection) groups. Patients were followed-up for 24 weeks. Liver function and adverse events were recorded. Survival analysis was performed. PBSCT improved blood ammonia levels at 1 week (P<0.05). The level of total bilirubin, international normalized ratio, and creatinine showed significant differences in the 4th week of treatment (P<0.05). The survival rates of the PE, G-CSF, and PBSCT groups were 50, 65, and 85% at 90 days (P=0.034). There was a significant difference in 90-day survival between the PE and PBSCT groups (P=0.021). The preliminary results suggested that PBSCT was safe, with a possibility of improved 90-day survival in patients with HBV-ACLF.Associação Brasileira de Divulgação Científica2020-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2020001100613Brazilian Journal of Medical and Biological Research v.53 n.11 2020reponame:Brazilian Journal of Medical and Biological Researchinstname:Associação Brasileira de Divulgação Científica (ABDC)instacron:ABDC10.1590/1414-431x20209728info:eu-repo/semantics/openAccessZhu,BingYou,ShaoliRong,YihuiYu,QiangLv,SaSong,FangjiaoLiu,HonglingWang,HuamingZhao,JunLi,DongzeLiu,WanshuXin,Shaojieeng2020-10-05T00:00:00Zoai:scielo:S0100-879X2020001100613Revistahttps://www.bjournal.org/https://old.scielo.br/oai/scielo-oai.phpbjournal@terra.com.br||bjournal@terra.com.br1414-431X0100-879Xopendoar:2020-10-05T00:00Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)false |
dc.title.none.fl_str_mv |
A novel stem cell therapy for hepatitis B virus-related acute-on-chronic liver failure |
title |
A novel stem cell therapy for hepatitis B virus-related acute-on-chronic liver failure |
spellingShingle |
A novel stem cell therapy for hepatitis B virus-related acute-on-chronic liver failure Zhu,Bing Stem cell transplantation Hepatic artery transfusion Acute-on-chronic liver failure Hepatitis B virus Randomized controlled trial |
title_short |
A novel stem cell therapy for hepatitis B virus-related acute-on-chronic liver failure |
title_full |
A novel stem cell therapy for hepatitis B virus-related acute-on-chronic liver failure |
title_fullStr |
A novel stem cell therapy for hepatitis B virus-related acute-on-chronic liver failure |
title_full_unstemmed |
A novel stem cell therapy for hepatitis B virus-related acute-on-chronic liver failure |
title_sort |
A novel stem cell therapy for hepatitis B virus-related acute-on-chronic liver failure |
author |
Zhu,Bing |
author_facet |
Zhu,Bing You,Shaoli Rong,Yihui Yu,Qiang Lv,Sa Song,Fangjiao Liu,Hongling Wang,Huaming Zhao,Jun Li,Dongze Liu,Wanshu Xin,Shaojie |
author_role |
author |
author2 |
You,Shaoli Rong,Yihui Yu,Qiang Lv,Sa Song,Fangjiao Liu,Hongling Wang,Huaming Zhao,Jun Li,Dongze Liu,Wanshu Xin,Shaojie |
author2_role |
author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Zhu,Bing You,Shaoli Rong,Yihui Yu,Qiang Lv,Sa Song,Fangjiao Liu,Hongling Wang,Huaming Zhao,Jun Li,Dongze Liu,Wanshu Xin,Shaojie |
dc.subject.por.fl_str_mv |
Stem cell transplantation Hepatic artery transfusion Acute-on-chronic liver failure Hepatitis B virus Randomized controlled trial |
topic |
Stem cell transplantation Hepatic artery transfusion Acute-on-chronic liver failure Hepatitis B virus Randomized controlled trial |
description |
The aim of this study was to propose a stem cell therapy for hepatitis B virus (HBV)-related acute-on-chronic liver failure (ACLF) based on plasma exchange (PE) for peripheral blood stem cell (PBSC) collection and examine its safety and efficacy. Sixty patients (n=20 in each group) were randomized to PE (PE alone), granulocyte colony-stimulating factor (G-CSF) (PE after G-CSF treatment), and PBSC transplantation (PBSCT) (G-CSF, PE, PBSC collection and hepatic artery injection) groups. Patients were followed-up for 24 weeks. Liver function and adverse events were recorded. Survival analysis was performed. PBSCT improved blood ammonia levels at 1 week (P<0.05). The level of total bilirubin, international normalized ratio, and creatinine showed significant differences in the 4th week of treatment (P<0.05). The survival rates of the PE, G-CSF, and PBSCT groups were 50, 65, and 85% at 90 days (P=0.034). There was a significant difference in 90-day survival between the PE and PBSCT groups (P=0.021). The preliminary results suggested that PBSCT was safe, with a possibility of improved 90-day survival in patients with HBV-ACLF. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2020001100613 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2020001100613 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1414-431x20209728 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
dc.source.none.fl_str_mv |
Brazilian Journal of Medical and Biological Research v.53 n.11 2020 reponame:Brazilian Journal of Medical and Biological Research instname:Associação Brasileira de Divulgação Científica (ABDC) instacron:ABDC |
instname_str |
Associação Brasileira de Divulgação Científica (ABDC) |
instacron_str |
ABDC |
institution |
ABDC |
reponame_str |
Brazilian Journal of Medical and Biological Research |
collection |
Brazilian Journal of Medical and Biological Research |
repository.name.fl_str_mv |
Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC) |
repository.mail.fl_str_mv |
bjournal@terra.com.br||bjournal@terra.com.br |
_version_ |
1754302947999612928 |