Liposomal photosensitizers: potential platforms for anticancer photodynamic therapy

Detalhes bibliográficos
Autor(a) principal: Muehlmann,L.A.
Data de Publicação: 2011
Outros Autores: Joanitti,G.A., Silva,J.R., Longo,J.P.F., Azevedo,R.B.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Medical and Biological Research
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000800001
Resumo: Photodynamic therapy is a well-established and clinically approved treatment for several types of cancer. Antineoplastic photodynamic therapy is based on photosensitizers, i.e., drugs that absorb photons translating light energy into a chemical potential that damages tumor tissues. Despite the encouraging clinical results with the approved photosensitizers available today, the prolonged skin phototoxicity, poor selectivity for diseased tissues, hydrophobic nature, and extended retention in the host organism shown by these drugs have stimulated researchers to develop new formulations for photodynamic therapy. In this context, due to their amphiphilic characteristic (compatibility with both hydrophobic and hydrophilic substances), liposomes have proven to be suitable carriers for photosensitizers, improving the photophysical properties of the photosensitizers. Moreover, as nanostructured drug delivery systems, liposomes improve the efficiency and safety of antineoplastic photodynamic therapy, mainly by the classical phenomenon of extended permeation and retention. Therefore, the association of photosensitizers with liposomes has been extensively studied. In this review, both current knowledge and future perspectives on liposomal carriers for antineoplastic photodynamic therapy are critically discussed.
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spelling Liposomal photosensitizers: potential platforms for anticancer photodynamic therapyPhotodynamic therapyLiposomeAntineoplastic therapyCancerPhotosensitizerPhotodynamic therapy is a well-established and clinically approved treatment for several types of cancer. Antineoplastic photodynamic therapy is based on photosensitizers, i.e., drugs that absorb photons translating light energy into a chemical potential that damages tumor tissues. Despite the encouraging clinical results with the approved photosensitizers available today, the prolonged skin phototoxicity, poor selectivity for diseased tissues, hydrophobic nature, and extended retention in the host organism shown by these drugs have stimulated researchers to develop new formulations for photodynamic therapy. In this context, due to their amphiphilic characteristic (compatibility with both hydrophobic and hydrophilic substances), liposomes have proven to be suitable carriers for photosensitizers, improving the photophysical properties of the photosensitizers. Moreover, as nanostructured drug delivery systems, liposomes improve the efficiency and safety of antineoplastic photodynamic therapy, mainly by the classical phenomenon of extended permeation and retention. Therefore, the association of photosensitizers with liposomes has been extensively studied. In this review, both current knowledge and future perspectives on liposomal carriers for antineoplastic photodynamic therapy are critically discussed.Associação Brasileira de Divulgação Científica2011-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000800001Brazilian Journal of Medical and Biological Research v.44 n.8 2011reponame:Brazilian Journal of Medical and Biological Researchinstname:Associação Brasileira de Divulgação Científica (ABDC)instacron:ABDC10.1590/S0100-879X2011007500091info:eu-repo/semantics/openAccessMuehlmann,L.A.Joanitti,G.A.Silva,J.R.Longo,J.P.F.Azevedo,R.B.eng2011-09-27T00:00:00Zoai:scielo:S0100-879X2011000800001Revistahttps://www.bjournal.org/https://old.scielo.br/oai/scielo-oai.phpbjournal@terra.com.br||bjournal@terra.com.br1414-431X0100-879Xopendoar:2011-09-27T00:00Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)false
dc.title.none.fl_str_mv Liposomal photosensitizers: potential platforms for anticancer photodynamic therapy
title Liposomal photosensitizers: potential platforms for anticancer photodynamic therapy
spellingShingle Liposomal photosensitizers: potential platforms for anticancer photodynamic therapy
Muehlmann,L.A.
Photodynamic therapy
Liposome
Antineoplastic therapy
Cancer
Photosensitizer
title_short Liposomal photosensitizers: potential platforms for anticancer photodynamic therapy
title_full Liposomal photosensitizers: potential platforms for anticancer photodynamic therapy
title_fullStr Liposomal photosensitizers: potential platforms for anticancer photodynamic therapy
title_full_unstemmed Liposomal photosensitizers: potential platforms for anticancer photodynamic therapy
title_sort Liposomal photosensitizers: potential platforms for anticancer photodynamic therapy
author Muehlmann,L.A.
author_facet Muehlmann,L.A.
Joanitti,G.A.
Silva,J.R.
Longo,J.P.F.
Azevedo,R.B.
author_role author
author2 Joanitti,G.A.
Silva,J.R.
Longo,J.P.F.
Azevedo,R.B.
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Muehlmann,L.A.
Joanitti,G.A.
Silva,J.R.
Longo,J.P.F.
Azevedo,R.B.
dc.subject.por.fl_str_mv Photodynamic therapy
Liposome
Antineoplastic therapy
Cancer
Photosensitizer
topic Photodynamic therapy
Liposome
Antineoplastic therapy
Cancer
Photosensitizer
description Photodynamic therapy is a well-established and clinically approved treatment for several types of cancer. Antineoplastic photodynamic therapy is based on photosensitizers, i.e., drugs that absorb photons translating light energy into a chemical potential that damages tumor tissues. Despite the encouraging clinical results with the approved photosensitizers available today, the prolonged skin phototoxicity, poor selectivity for diseased tissues, hydrophobic nature, and extended retention in the host organism shown by these drugs have stimulated researchers to develop new formulations for photodynamic therapy. In this context, due to their amphiphilic characteristic (compatibility with both hydrophobic and hydrophilic substances), liposomes have proven to be suitable carriers for photosensitizers, improving the photophysical properties of the photosensitizers. Moreover, as nanostructured drug delivery systems, liposomes improve the efficiency and safety of antineoplastic photodynamic therapy, mainly by the classical phenomenon of extended permeation and retention. Therefore, the association of photosensitizers with liposomes has been extensively studied. In this review, both current knowledge and future perspectives on liposomal carriers for antineoplastic photodynamic therapy are critically discussed.
publishDate 2011
dc.date.none.fl_str_mv 2011-08-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000800001
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000800001
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0100-879X2011007500091
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
dc.source.none.fl_str_mv Brazilian Journal of Medical and Biological Research v.44 n.8 2011
reponame:Brazilian Journal of Medical and Biological Research
instname:Associação Brasileira de Divulgação Científica (ABDC)
instacron:ABDC
instname_str Associação Brasileira de Divulgação Científica (ABDC)
instacron_str ABDC
institution ABDC
reponame_str Brazilian Journal of Medical and Biological Research
collection Brazilian Journal of Medical and Biological Research
repository.name.fl_str_mv Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)
repository.mail.fl_str_mv bjournal@terra.com.br||bjournal@terra.com.br
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