Reviewing physical exercise in non-obese diabetic Goto-Kakizaki rats
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Medical and Biological Research |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2022000100304 |
Resumo: | There is a high incidence of non-obese type 2 diabetes mellitus (non-obese-T2DM) cases, particularly in Asian countries, for which the pathogenesis remains mainly unclear. Interestingly, Goto-Kakizaki (GK) rats spontaneously develop insulin resistance (IR) and non-obese-T2DM, making them a lean diabetes model. Physical exercise is a non-pharmacological therapeutic approach to reduce adipose tissue mass, improving peripheral IR, glycemic control, and quality of life in obese animals or humans with T2DM. In this narrative review, we selected and analyzed the published literature on the effects of physical exercise on the metabolic features associated with non-obese-T2DM. Only randomized controlled trials with regular physical exercise training, freely executed physical activity, or skeletal muscle stimulation protocols in GK rats published after 2008 were included. The results indicated that exercise reduces plasma insulin levels, increases skeletal muscle glycogen content, improves exercise tolerance, protects renal and myocardial function, and enhances blood oxygen flow in GK rats. |
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Brazilian Journal of Medical and Biological Research |
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Reviewing physical exercise in non-obese diabetic Goto-Kakizaki ratsExercise intensityInsulin resistanceGlycemic controlType 2 diabetes mellitusSkeletal muscleMetabolismThere is a high incidence of non-obese type 2 diabetes mellitus (non-obese-T2DM) cases, particularly in Asian countries, for which the pathogenesis remains mainly unclear. Interestingly, Goto-Kakizaki (GK) rats spontaneously develop insulin resistance (IR) and non-obese-T2DM, making them a lean diabetes model. Physical exercise is a non-pharmacological therapeutic approach to reduce adipose tissue mass, improving peripheral IR, glycemic control, and quality of life in obese animals or humans with T2DM. In this narrative review, we selected and analyzed the published literature on the effects of physical exercise on the metabolic features associated with non-obese-T2DM. Only randomized controlled trials with regular physical exercise training, freely executed physical activity, or skeletal muscle stimulation protocols in GK rats published after 2008 were included. The results indicated that exercise reduces plasma insulin levels, increases skeletal muscle glycogen content, improves exercise tolerance, protects renal and myocardial function, and enhances blood oxygen flow in GK rats.Associação Brasileira de Divulgação Científica2022-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2022000100304Brazilian Journal of Medical and Biological Research v.55 2022reponame:Brazilian Journal of Medical and Biological Researchinstname:Associação Brasileira de Divulgação Científica (ABDC)instacron:ABDC10.1590/1414-431x2022e11795info:eu-repo/semantics/openAccessGalán,B.S.M.Serdan,T.D.A.Rodrigues,L.E.Manoel,R.Gorjão,R.Masi,L.N.Pithon-Curi,T.C.Curi,R.Hirabara,S.M.eng2022-05-25T00:00:00Zoai:scielo:S0100-879X2022000100304Revistahttps://www.bjournal.org/https://old.scielo.br/oai/scielo-oai.phpbjournal@terra.com.br||bjournal@terra.com.br1414-431X0100-879Xopendoar:2022-05-25T00:00Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)false |
dc.title.none.fl_str_mv |
Reviewing physical exercise in non-obese diabetic Goto-Kakizaki rats |
title |
Reviewing physical exercise in non-obese diabetic Goto-Kakizaki rats |
spellingShingle |
Reviewing physical exercise in non-obese diabetic Goto-Kakizaki rats Galán,B.S.M. Exercise intensity Insulin resistance Glycemic control Type 2 diabetes mellitus Skeletal muscle Metabolism |
title_short |
Reviewing physical exercise in non-obese diabetic Goto-Kakizaki rats |
title_full |
Reviewing physical exercise in non-obese diabetic Goto-Kakizaki rats |
title_fullStr |
Reviewing physical exercise in non-obese diabetic Goto-Kakizaki rats |
title_full_unstemmed |
Reviewing physical exercise in non-obese diabetic Goto-Kakizaki rats |
title_sort |
Reviewing physical exercise in non-obese diabetic Goto-Kakizaki rats |
author |
Galán,B.S.M. |
author_facet |
Galán,B.S.M. Serdan,T.D.A. Rodrigues,L.E. Manoel,R. Gorjão,R. Masi,L.N. Pithon-Curi,T.C. Curi,R. Hirabara,S.M. |
author_role |
author |
author2 |
Serdan,T.D.A. Rodrigues,L.E. Manoel,R. Gorjão,R. Masi,L.N. Pithon-Curi,T.C. Curi,R. Hirabara,S.M. |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Galán,B.S.M. Serdan,T.D.A. Rodrigues,L.E. Manoel,R. Gorjão,R. Masi,L.N. Pithon-Curi,T.C. Curi,R. Hirabara,S.M. |
dc.subject.por.fl_str_mv |
Exercise intensity Insulin resistance Glycemic control Type 2 diabetes mellitus Skeletal muscle Metabolism |
topic |
Exercise intensity Insulin resistance Glycemic control Type 2 diabetes mellitus Skeletal muscle Metabolism |
description |
There is a high incidence of non-obese type 2 diabetes mellitus (non-obese-T2DM) cases, particularly in Asian countries, for which the pathogenesis remains mainly unclear. Interestingly, Goto-Kakizaki (GK) rats spontaneously develop insulin resistance (IR) and non-obese-T2DM, making them a lean diabetes model. Physical exercise is a non-pharmacological therapeutic approach to reduce adipose tissue mass, improving peripheral IR, glycemic control, and quality of life in obese animals or humans with T2DM. In this narrative review, we selected and analyzed the published literature on the effects of physical exercise on the metabolic features associated with non-obese-T2DM. Only randomized controlled trials with regular physical exercise training, freely executed physical activity, or skeletal muscle stimulation protocols in GK rats published after 2008 were included. The results indicated that exercise reduces plasma insulin levels, increases skeletal muscle glycogen content, improves exercise tolerance, protects renal and myocardial function, and enhances blood oxygen flow in GK rats. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2022000100304 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2022000100304 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1414-431x2022e11795 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
dc.source.none.fl_str_mv |
Brazilian Journal of Medical and Biological Research v.55 2022 reponame:Brazilian Journal of Medical and Biological Research instname:Associação Brasileira de Divulgação Científica (ABDC) instacron:ABDC |
instname_str |
Associação Brasileira de Divulgação Científica (ABDC) |
instacron_str |
ABDC |
institution |
ABDC |
reponame_str |
Brazilian Journal of Medical and Biological Research |
collection |
Brazilian Journal of Medical and Biological Research |
repository.name.fl_str_mv |
Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC) |
repository.mail.fl_str_mv |
bjournal@terra.com.br||bjournal@terra.com.br |
_version_ |
1754302948885659648 |