Is there a higher frequency of anal dysplasia and infection by human papillomavirus in Crohn's disease patients?
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Medical and Biological Research |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2022000100671 |
Resumo: | The aim of this study was to compare the frequency of dysplasia and human papillomavirus (HPV) infection in the anal canal of patients with Crohn's disease (CD) with a control group and assess whether there is a correlation between use of immunosuppressants and anal manifestation of CD. Patients with CD and control individuals were submitted to anal cytology and material collection for polymerase chain reaction (PCR). The cytology was classified as normal, atypical squamous cells of undetermined significance (ASCUS), low-grade squamous intraepithelial lesion (LSIL), or high-grade (HSIL). PCR was considered positive or negative according to virus presence or absence. A total of 117 patients were included (54 in the control group and 63 in the CD group, being 32 without and 31 with immunosuppressants). ASCUS and LSIL were found in 25.9 and 22.2% of control patients and 28.6 and 39.7% of CD patients. HPV was identified in 14.8% of the control group and 27% of the CD group. In CD patients, HPV was found in 37.5 and 16.1% of those without and with immunosuppressants, respectively. Patients with perianal involvement had 15.6% of PCR positivity. There was no statistical difference in dysplasia and infection by HPV between the groups. Use of immunosuppressants did not influence the result, but anal manifestation was inversely proportional to viral detection. |
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Is there a higher frequency of anal dysplasia and infection by human papillomavirus in Crohn's disease patients?Anal cytologyPolymerase chain reactionDysplasiaCase-controlHuman papillomavirusCrohn's diseaseThe aim of this study was to compare the frequency of dysplasia and human papillomavirus (HPV) infection in the anal canal of patients with Crohn's disease (CD) with a control group and assess whether there is a correlation between use of immunosuppressants and anal manifestation of CD. Patients with CD and control individuals were submitted to anal cytology and material collection for polymerase chain reaction (PCR). The cytology was classified as normal, atypical squamous cells of undetermined significance (ASCUS), low-grade squamous intraepithelial lesion (LSIL), or high-grade (HSIL). PCR was considered positive or negative according to virus presence or absence. A total of 117 patients were included (54 in the control group and 63 in the CD group, being 32 without and 31 with immunosuppressants). ASCUS and LSIL were found in 25.9 and 22.2% of control patients and 28.6 and 39.7% of CD patients. HPV was identified in 14.8% of the control group and 27% of the CD group. In CD patients, HPV was found in 37.5 and 16.1% of those without and with immunosuppressants, respectively. Patients with perianal involvement had 15.6% of PCR positivity. There was no statistical difference in dysplasia and infection by HPV between the groups. Use of immunosuppressants did not influence the result, but anal manifestation was inversely proportional to viral detection.Associação Brasileira de Divulgação Científica2022-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2022000100671Brazilian Journal of Medical and Biological Research v.55 2022reponame:Brazilian Journal of Medical and Biological Researchinstname:Associação Brasileira de Divulgação Científica (ABDC)instacron:ABDC10.1590/1414-431x2022e12141info:eu-repo/semantics/openAccessGuzela,V.R.Sobrado Junior,C.W.Nadal,S.R.Villa,L.L.Mota,G.R.Gonçalves,A.P.Nadal,C.R.M.Nahas,C.S.R.Nahas,S.C.eng2022-10-26T00:00:00Zoai:scielo:S0100-879X2022000100671Revistahttps://www.bjournal.org/https://old.scielo.br/oai/scielo-oai.phpbjournal@terra.com.br||bjournal@terra.com.br1414-431X0100-879Xopendoar:2022-10-26T00:00Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)false |
dc.title.none.fl_str_mv |
Is there a higher frequency of anal dysplasia and infection by human papillomavirus in Crohn's disease patients? |
title |
Is there a higher frequency of anal dysplasia and infection by human papillomavirus in Crohn's disease patients? |
spellingShingle |
Is there a higher frequency of anal dysplasia and infection by human papillomavirus in Crohn's disease patients? Guzela,V.R. Anal cytology Polymerase chain reaction Dysplasia Case-control Human papillomavirus Crohn's disease |
title_short |
Is there a higher frequency of anal dysplasia and infection by human papillomavirus in Crohn's disease patients? |
title_full |
Is there a higher frequency of anal dysplasia and infection by human papillomavirus in Crohn's disease patients? |
title_fullStr |
Is there a higher frequency of anal dysplasia and infection by human papillomavirus in Crohn's disease patients? |
title_full_unstemmed |
Is there a higher frequency of anal dysplasia and infection by human papillomavirus in Crohn's disease patients? |
title_sort |
Is there a higher frequency of anal dysplasia and infection by human papillomavirus in Crohn's disease patients? |
author |
Guzela,V.R. |
author_facet |
Guzela,V.R. Sobrado Junior,C.W. Nadal,S.R. Villa,L.L. Mota,G.R. Gonçalves,A.P. Nadal,C.R.M. Nahas,C.S.R. Nahas,S.C. |
author_role |
author |
author2 |
Sobrado Junior,C.W. Nadal,S.R. Villa,L.L. Mota,G.R. Gonçalves,A.P. Nadal,C.R.M. Nahas,C.S.R. Nahas,S.C. |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Guzela,V.R. Sobrado Junior,C.W. Nadal,S.R. Villa,L.L. Mota,G.R. Gonçalves,A.P. Nadal,C.R.M. Nahas,C.S.R. Nahas,S.C. |
dc.subject.por.fl_str_mv |
Anal cytology Polymerase chain reaction Dysplasia Case-control Human papillomavirus Crohn's disease |
topic |
Anal cytology Polymerase chain reaction Dysplasia Case-control Human papillomavirus Crohn's disease |
description |
The aim of this study was to compare the frequency of dysplasia and human papillomavirus (HPV) infection in the anal canal of patients with Crohn's disease (CD) with a control group and assess whether there is a correlation between use of immunosuppressants and anal manifestation of CD. Patients with CD and control individuals were submitted to anal cytology and material collection for polymerase chain reaction (PCR). The cytology was classified as normal, atypical squamous cells of undetermined significance (ASCUS), low-grade squamous intraepithelial lesion (LSIL), or high-grade (HSIL). PCR was considered positive or negative according to virus presence or absence. A total of 117 patients were included (54 in the control group and 63 in the CD group, being 32 without and 31 with immunosuppressants). ASCUS and LSIL were found in 25.9 and 22.2% of control patients and 28.6 and 39.7% of CD patients. HPV was identified in 14.8% of the control group and 27% of the CD group. In CD patients, HPV was found in 37.5 and 16.1% of those without and with immunosuppressants, respectively. Patients with perianal involvement had 15.6% of PCR positivity. There was no statistical difference in dysplasia and infection by HPV between the groups. Use of immunosuppressants did not influence the result, but anal manifestation was inversely proportional to viral detection. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2022000100671 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2022000100671 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1414-431x2022e12141 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
dc.source.none.fl_str_mv |
Brazilian Journal of Medical and Biological Research v.55 2022 reponame:Brazilian Journal of Medical and Biological Research instname:Associação Brasileira de Divulgação Científica (ABDC) instacron:ABDC |
instname_str |
Associação Brasileira de Divulgação Científica (ABDC) |
instacron_str |
ABDC |
institution |
ABDC |
reponame_str |
Brazilian Journal of Medical and Biological Research |
collection |
Brazilian Journal of Medical and Biological Research |
repository.name.fl_str_mv |
Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC) |
repository.mail.fl_str_mv |
bjournal@terra.com.br||bjournal@terra.com.br |
_version_ |
1754302949082791936 |