Is there a higher frequency of anal dysplasia and infection by human papillomavirus in Crohn's disease patients?

Detalhes bibliográficos
Autor(a) principal: Guzela,V.R.
Data de Publicação: 2022
Outros Autores: Sobrado Junior,C.W., Nadal,S.R., Villa,L.L., Mota,G.R., Gonçalves,A.P., Nadal,C.R.M., Nahas,C.S.R., Nahas,S.C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Medical and Biological Research
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2022000100671
Resumo: The aim of this study was to compare the frequency of dysplasia and human papillomavirus (HPV) infection in the anal canal of patients with Crohn's disease (CD) with a control group and assess whether there is a correlation between use of immunosuppressants and anal manifestation of CD. Patients with CD and control individuals were submitted to anal cytology and material collection for polymerase chain reaction (PCR). The cytology was classified as normal, atypical squamous cells of undetermined significance (ASCUS), low-grade squamous intraepithelial lesion (LSIL), or high-grade (HSIL). PCR was considered positive or negative according to virus presence or absence. A total of 117 patients were included (54 in the control group and 63 in the CD group, being 32 without and 31 with immunosuppressants). ASCUS and LSIL were found in 25.9 and 22.2% of control patients and 28.6 and 39.7% of CD patients. HPV was identified in 14.8% of the control group and 27% of the CD group. In CD patients, HPV was found in 37.5 and 16.1% of those without and with immunosuppressants, respectively. Patients with perianal involvement had 15.6% of PCR positivity. There was no statistical difference in dysplasia and infection by HPV between the groups. Use of immunosuppressants did not influence the result, but anal manifestation was inversely proportional to viral detection.
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spelling Is there a higher frequency of anal dysplasia and infection by human papillomavirus in Crohn's disease patients?Anal cytologyPolymerase chain reactionDysplasiaCase-controlHuman papillomavirusCrohn's diseaseThe aim of this study was to compare the frequency of dysplasia and human papillomavirus (HPV) infection in the anal canal of patients with Crohn's disease (CD) with a control group and assess whether there is a correlation between use of immunosuppressants and anal manifestation of CD. Patients with CD and control individuals were submitted to anal cytology and material collection for polymerase chain reaction (PCR). The cytology was classified as normal, atypical squamous cells of undetermined significance (ASCUS), low-grade squamous intraepithelial lesion (LSIL), or high-grade (HSIL). PCR was considered positive or negative according to virus presence or absence. A total of 117 patients were included (54 in the control group and 63 in the CD group, being 32 without and 31 with immunosuppressants). ASCUS and LSIL were found in 25.9 and 22.2% of control patients and 28.6 and 39.7% of CD patients. HPV was identified in 14.8% of the control group and 27% of the CD group. In CD patients, HPV was found in 37.5 and 16.1% of those without and with immunosuppressants, respectively. Patients with perianal involvement had 15.6% of PCR positivity. There was no statistical difference in dysplasia and infection by HPV between the groups. Use of immunosuppressants did not influence the result, but anal manifestation was inversely proportional to viral detection.Associação Brasileira de Divulgação Científica2022-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2022000100671Brazilian Journal of Medical and Biological Research v.55 2022reponame:Brazilian Journal of Medical and Biological Researchinstname:Associação Brasileira de Divulgação Científica (ABDC)instacron:ABDC10.1590/1414-431x2022e12141info:eu-repo/semantics/openAccessGuzela,V.R.Sobrado Junior,C.W.Nadal,S.R.Villa,L.L.Mota,G.R.Gonçalves,A.P.Nadal,C.R.M.Nahas,C.S.R.Nahas,S.C.eng2022-10-26T00:00:00Zoai:scielo:S0100-879X2022000100671Revistahttps://www.bjournal.org/https://old.scielo.br/oai/scielo-oai.phpbjournal@terra.com.br||bjournal@terra.com.br1414-431X0100-879Xopendoar:2022-10-26T00:00Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)false
dc.title.none.fl_str_mv Is there a higher frequency of anal dysplasia and infection by human papillomavirus in Crohn's disease patients?
title Is there a higher frequency of anal dysplasia and infection by human papillomavirus in Crohn's disease patients?
spellingShingle Is there a higher frequency of anal dysplasia and infection by human papillomavirus in Crohn's disease patients?
Guzela,V.R.
Anal cytology
Polymerase chain reaction
Dysplasia
Case-control
Human papillomavirus
Crohn's disease
title_short Is there a higher frequency of anal dysplasia and infection by human papillomavirus in Crohn's disease patients?
title_full Is there a higher frequency of anal dysplasia and infection by human papillomavirus in Crohn's disease patients?
title_fullStr Is there a higher frequency of anal dysplasia and infection by human papillomavirus in Crohn's disease patients?
title_full_unstemmed Is there a higher frequency of anal dysplasia and infection by human papillomavirus in Crohn's disease patients?
title_sort Is there a higher frequency of anal dysplasia and infection by human papillomavirus in Crohn's disease patients?
author Guzela,V.R.
author_facet Guzela,V.R.
Sobrado Junior,C.W.
Nadal,S.R.
Villa,L.L.
Mota,G.R.
Gonçalves,A.P.
Nadal,C.R.M.
Nahas,C.S.R.
Nahas,S.C.
author_role author
author2 Sobrado Junior,C.W.
Nadal,S.R.
Villa,L.L.
Mota,G.R.
Gonçalves,A.P.
Nadal,C.R.M.
Nahas,C.S.R.
Nahas,S.C.
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Guzela,V.R.
Sobrado Junior,C.W.
Nadal,S.R.
Villa,L.L.
Mota,G.R.
Gonçalves,A.P.
Nadal,C.R.M.
Nahas,C.S.R.
Nahas,S.C.
dc.subject.por.fl_str_mv Anal cytology
Polymerase chain reaction
Dysplasia
Case-control
Human papillomavirus
Crohn's disease
topic Anal cytology
Polymerase chain reaction
Dysplasia
Case-control
Human papillomavirus
Crohn's disease
description The aim of this study was to compare the frequency of dysplasia and human papillomavirus (HPV) infection in the anal canal of patients with Crohn's disease (CD) with a control group and assess whether there is a correlation between use of immunosuppressants and anal manifestation of CD. Patients with CD and control individuals were submitted to anal cytology and material collection for polymerase chain reaction (PCR). The cytology was classified as normal, atypical squamous cells of undetermined significance (ASCUS), low-grade squamous intraepithelial lesion (LSIL), or high-grade (HSIL). PCR was considered positive or negative according to virus presence or absence. A total of 117 patients were included (54 in the control group and 63 in the CD group, being 32 without and 31 with immunosuppressants). ASCUS and LSIL were found in 25.9 and 22.2% of control patients and 28.6 and 39.7% of CD patients. HPV was identified in 14.8% of the control group and 27% of the CD group. In CD patients, HPV was found in 37.5 and 16.1% of those without and with immunosuppressants, respectively. Patients with perianal involvement had 15.6% of PCR positivity. There was no statistical difference in dysplasia and infection by HPV between the groups. Use of immunosuppressants did not influence the result, but anal manifestation was inversely proportional to viral detection.
publishDate 2022
dc.date.none.fl_str_mv 2022-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2022000100671
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2022000100671
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/1414-431x2022e12141
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
dc.source.none.fl_str_mv Brazilian Journal of Medical and Biological Research v.55 2022
reponame:Brazilian Journal of Medical and Biological Research
instname:Associação Brasileira de Divulgação Científica (ABDC)
instacron:ABDC
instname_str Associação Brasileira de Divulgação Científica (ABDC)
instacron_str ABDC
institution ABDC
reponame_str Brazilian Journal of Medical and Biological Research
collection Brazilian Journal of Medical and Biological Research
repository.name.fl_str_mv Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)
repository.mail.fl_str_mv bjournal@terra.com.br||bjournal@terra.com.br
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