Mapping and signaling of neural pathways involved in the regulation of hydromineral homeostasis
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Medical and Biological Research |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013000400327 |
Resumo: | Several forebrain and brainstem neurochemical circuitries interact with peripheral neural and humoral signals to collaboratively maintain both the volume and osmolality of extracellular fluids. Although much progress has been made over the past decades in the understanding of complex mechanisms underlying neuroendocrine control of hydromineral homeostasis, several issues still remain to be clarified. The use of techniques such as molecular biology, neuronal tracing, electrophysiology, immunohistochemistry, and microinfusions has significantly improved our ability to identify neuronal phenotypes and their signals, including those related to neuron-glia interactions. Accordingly, neurons have been shown to produce and release a large number of chemical mediators (neurotransmitters, neurohormones and neuromodulators) into the interstitial space, which include not only classic neurotransmitters, such as acetylcholine, amines (noradrenaline, serotonin) and amino acids (glutamate, GABA), but also gaseous (nitric oxide, carbon monoxide and hydrogen sulfide) and lipid-derived (endocannabinoids) mediators. This efferent response, initiated within the neuronal environment, recruits several peripheral effectors, such as hormones (glucocorticoids, angiotensin II, estrogen), which in turn modulate central nervous system responsiveness to systemic challenges. Therefore, in this review, we shall evaluate in an integrated manner the physiological control of body fluid homeostasis from the molecular aspects to the systemic and integrated responses. |
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Mapping and signaling of neural pathways involved in the regulation of hydromineral homeostasisHypothalamusGaseous neuromodulatorsNeuropeptidesEndocannabinoidsGlial cellsNeurotransmittersSeveral forebrain and brainstem neurochemical circuitries interact with peripheral neural and humoral signals to collaboratively maintain both the volume and osmolality of extracellular fluids. Although much progress has been made over the past decades in the understanding of complex mechanisms underlying neuroendocrine control of hydromineral homeostasis, several issues still remain to be clarified. The use of techniques such as molecular biology, neuronal tracing, electrophysiology, immunohistochemistry, and microinfusions has significantly improved our ability to identify neuronal phenotypes and their signals, including those related to neuron-glia interactions. Accordingly, neurons have been shown to produce and release a large number of chemical mediators (neurotransmitters, neurohormones and neuromodulators) into the interstitial space, which include not only classic neurotransmitters, such as acetylcholine, amines (noradrenaline, serotonin) and amino acids (glutamate, GABA), but also gaseous (nitric oxide, carbon monoxide and hydrogen sulfide) and lipid-derived (endocannabinoids) mediators. This efferent response, initiated within the neuronal environment, recruits several peripheral effectors, such as hormones (glucocorticoids, angiotensin II, estrogen), which in turn modulate central nervous system responsiveness to systemic challenges. Therefore, in this review, we shall evaluate in an integrated manner the physiological control of body fluid homeostasis from the molecular aspects to the systemic and integrated responses.Associação Brasileira de Divulgação Científica2013-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013000400327Brazilian Journal of Medical and Biological Research v.46 n.4 2013reponame:Brazilian Journal of Medical and Biological Researchinstname:Associação Brasileira de Divulgação Científica (ABDC)instacron:ABDC10.1590/1414-431X20132788info:eu-repo/semantics/openAccessAntunes-Rodrigues,J.Ruginsk,S.G.Mecawi,A.S.Margatho,L.O.Cruz,J.C.Vilhena-Franco,T.Reis,W.L.Ventura,R.R.Reis,L.C.Vivas,L.M.Elias,L.L.K.eng2015-10-08T00:00:00Zoai:scielo:S0100-879X2013000400327Revistahttps://www.bjournal.org/https://old.scielo.br/oai/scielo-oai.phpbjournal@terra.com.br||bjournal@terra.com.br1414-431X0100-879Xopendoar:2015-10-08T00:00Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)false |
dc.title.none.fl_str_mv |
Mapping and signaling of neural pathways involved in the regulation of hydromineral homeostasis |
title |
Mapping and signaling of neural pathways involved in the regulation of hydromineral homeostasis |
spellingShingle |
Mapping and signaling of neural pathways involved in the regulation of hydromineral homeostasis Antunes-Rodrigues,J. Hypothalamus Gaseous neuromodulators Neuropeptides Endocannabinoids Glial cells Neurotransmitters |
title_short |
Mapping and signaling of neural pathways involved in the regulation of hydromineral homeostasis |
title_full |
Mapping and signaling of neural pathways involved in the regulation of hydromineral homeostasis |
title_fullStr |
Mapping and signaling of neural pathways involved in the regulation of hydromineral homeostasis |
title_full_unstemmed |
Mapping and signaling of neural pathways involved in the regulation of hydromineral homeostasis |
title_sort |
Mapping and signaling of neural pathways involved in the regulation of hydromineral homeostasis |
author |
Antunes-Rodrigues,J. |
author_facet |
Antunes-Rodrigues,J. Ruginsk,S.G. Mecawi,A.S. Margatho,L.O. Cruz,J.C. Vilhena-Franco,T. Reis,W.L. Ventura,R.R. Reis,L.C. Vivas,L.M. Elias,L.L.K. |
author_role |
author |
author2 |
Ruginsk,S.G. Mecawi,A.S. Margatho,L.O. Cruz,J.C. Vilhena-Franco,T. Reis,W.L. Ventura,R.R. Reis,L.C. Vivas,L.M. Elias,L.L.K. |
author2_role |
author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Antunes-Rodrigues,J. Ruginsk,S.G. Mecawi,A.S. Margatho,L.O. Cruz,J.C. Vilhena-Franco,T. Reis,W.L. Ventura,R.R. Reis,L.C. Vivas,L.M. Elias,L.L.K. |
dc.subject.por.fl_str_mv |
Hypothalamus Gaseous neuromodulators Neuropeptides Endocannabinoids Glial cells Neurotransmitters |
topic |
Hypothalamus Gaseous neuromodulators Neuropeptides Endocannabinoids Glial cells Neurotransmitters |
description |
Several forebrain and brainstem neurochemical circuitries interact with peripheral neural and humoral signals to collaboratively maintain both the volume and osmolality of extracellular fluids. Although much progress has been made over the past decades in the understanding of complex mechanisms underlying neuroendocrine control of hydromineral homeostasis, several issues still remain to be clarified. The use of techniques such as molecular biology, neuronal tracing, electrophysiology, immunohistochemistry, and microinfusions has significantly improved our ability to identify neuronal phenotypes and their signals, including those related to neuron-glia interactions. Accordingly, neurons have been shown to produce and release a large number of chemical mediators (neurotransmitters, neurohormones and neuromodulators) into the interstitial space, which include not only classic neurotransmitters, such as acetylcholine, amines (noradrenaline, serotonin) and amino acids (glutamate, GABA), but also gaseous (nitric oxide, carbon monoxide and hydrogen sulfide) and lipid-derived (endocannabinoids) mediators. This efferent response, initiated within the neuronal environment, recruits several peripheral effectors, such as hormones (glucocorticoids, angiotensin II, estrogen), which in turn modulate central nervous system responsiveness to systemic challenges. Therefore, in this review, we shall evaluate in an integrated manner the physiological control of body fluid homeostasis from the molecular aspects to the systemic and integrated responses. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-04-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013000400327 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013000400327 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1414-431X20132788 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
dc.source.none.fl_str_mv |
Brazilian Journal of Medical and Biological Research v.46 n.4 2013 reponame:Brazilian Journal of Medical and Biological Research instname:Associação Brasileira de Divulgação Científica (ABDC) instacron:ABDC |
instname_str |
Associação Brasileira de Divulgação Científica (ABDC) |
instacron_str |
ABDC |
institution |
ABDC |
reponame_str |
Brazilian Journal of Medical and Biological Research |
collection |
Brazilian Journal of Medical and Biological Research |
repository.name.fl_str_mv |
Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC) |
repository.mail.fl_str_mv |
bjournal@terra.com.br||bjournal@terra.com.br |
_version_ |
1754302942059429888 |