Amifostine protects from the peripheral sensory neuropathy induced by oxaliplatin in mice

Detalhes bibliográficos
Autor(a) principal: Pereira,A.F.
Data de Publicação: 2020
Outros Autores: Lino,J.A., Alves,B.W.F., Lisboa,M.R.P., Pontes,R.B., Leite,C.A.V.G., Nogueira,R.B., Lima-Júnior,R.C.P., Vale,M.L.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Medical and Biological Research
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2020001100601
Resumo: Sensory neuropathy is a dose-limiting side effect of oxaliplatin-based cancer treatment. This study investigated the antinociceptive effect of amifostine and its potential neuroprotective mechanisms on the oxaliplatin-related peripheral sensory neuropathy in mice. Oxaliplatin (1 mg/kg) was injected intravenously in Swiss albino male mice twice a week (total of nine injections), while amifostine (1, 5, 25, 50, and 100 mg/kg) was administered subcutaneously 30 min before oxaliplatin. Mechanical and thermal nociceptive tests were performed once a week for 49 days. Additionally, c-Fos, nitrotyrosine, and activating transcription factor 3 (ATF3) immunoexpressions were assessed in the dorsal root ganglia. In all doses, amifostine prevented the development of mechanical hyperalgesia and thermal allodynia induced by oxaliplatin (P<0.05). Amifostine at the dose of 25 mg/kg provided the best protection (P<0.05). Moreover, amifostine protected against neuronal hyperactivation, nitrosative stress, and neuronal damage in the dorsal root ganglia, detected by the reduced expression of c-Fos, nitrotyrosine, and ATF3 (P<0.05 vs the oxaliplatin-treated group). In conclusion, amifostine reduced the nociception induced by oxaliplatin in mice, suggesting the possible use of amifostine for the management of oxaliplatin-induced peripheral sensory neuropathy.
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spelling Amifostine protects from the peripheral sensory neuropathy induced by oxaliplatin in miceOxaliplatinAmifostineNeuropathyChemotherapyPainSensory neuropathy is a dose-limiting side effect of oxaliplatin-based cancer treatment. This study investigated the antinociceptive effect of amifostine and its potential neuroprotective mechanisms on the oxaliplatin-related peripheral sensory neuropathy in mice. Oxaliplatin (1 mg/kg) was injected intravenously in Swiss albino male mice twice a week (total of nine injections), while amifostine (1, 5, 25, 50, and 100 mg/kg) was administered subcutaneously 30 min before oxaliplatin. Mechanical and thermal nociceptive tests were performed once a week for 49 days. Additionally, c-Fos, nitrotyrosine, and activating transcription factor 3 (ATF3) immunoexpressions were assessed in the dorsal root ganglia. In all doses, amifostine prevented the development of mechanical hyperalgesia and thermal allodynia induced by oxaliplatin (P<0.05). Amifostine at the dose of 25 mg/kg provided the best protection (P<0.05). Moreover, amifostine protected against neuronal hyperactivation, nitrosative stress, and neuronal damage in the dorsal root ganglia, detected by the reduced expression of c-Fos, nitrotyrosine, and ATF3 (P<0.05 vs the oxaliplatin-treated group). In conclusion, amifostine reduced the nociception induced by oxaliplatin in mice, suggesting the possible use of amifostine for the management of oxaliplatin-induced peripheral sensory neuropathy.Associação Brasileira de Divulgação Científica2020-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2020001100601Brazilian Journal of Medical and Biological Research v.53 n.11 2020reponame:Brazilian Journal of Medical and Biological Researchinstname:Associação Brasileira de Divulgação Científica (ABDC)instacron:ABDC10.1590/1414-431x202010263info:eu-repo/semantics/openAccessPereira,A.F.Lino,J.A.Alves,B.W.F.Lisboa,M.R.P.Pontes,R.B.Leite,C.A.V.G.Nogueira,R.B.Lima-Júnior,R.C.P.Vale,M.L.eng2020-09-16T00:00:00Zoai:scielo:S0100-879X2020001100601Revistahttps://www.bjournal.org/https://old.scielo.br/oai/scielo-oai.phpbjournal@terra.com.br||bjournal@terra.com.br1414-431X0100-879Xopendoar:2020-09-16T00:00Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)false
dc.title.none.fl_str_mv Amifostine protects from the peripheral sensory neuropathy induced by oxaliplatin in mice
title Amifostine protects from the peripheral sensory neuropathy induced by oxaliplatin in mice
spellingShingle Amifostine protects from the peripheral sensory neuropathy induced by oxaliplatin in mice
Pereira,A.F.
Oxaliplatin
Amifostine
Neuropathy
Chemotherapy
Pain
title_short Amifostine protects from the peripheral sensory neuropathy induced by oxaliplatin in mice
title_full Amifostine protects from the peripheral sensory neuropathy induced by oxaliplatin in mice
title_fullStr Amifostine protects from the peripheral sensory neuropathy induced by oxaliplatin in mice
title_full_unstemmed Amifostine protects from the peripheral sensory neuropathy induced by oxaliplatin in mice
title_sort Amifostine protects from the peripheral sensory neuropathy induced by oxaliplatin in mice
author Pereira,A.F.
author_facet Pereira,A.F.
Lino,J.A.
Alves,B.W.F.
Lisboa,M.R.P.
Pontes,R.B.
Leite,C.A.V.G.
Nogueira,R.B.
Lima-Júnior,R.C.P.
Vale,M.L.
author_role author
author2 Lino,J.A.
Alves,B.W.F.
Lisboa,M.R.P.
Pontes,R.B.
Leite,C.A.V.G.
Nogueira,R.B.
Lima-Júnior,R.C.P.
Vale,M.L.
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Pereira,A.F.
Lino,J.A.
Alves,B.W.F.
Lisboa,M.R.P.
Pontes,R.B.
Leite,C.A.V.G.
Nogueira,R.B.
Lima-Júnior,R.C.P.
Vale,M.L.
dc.subject.por.fl_str_mv Oxaliplatin
Amifostine
Neuropathy
Chemotherapy
Pain
topic Oxaliplatin
Amifostine
Neuropathy
Chemotherapy
Pain
description Sensory neuropathy is a dose-limiting side effect of oxaliplatin-based cancer treatment. This study investigated the antinociceptive effect of amifostine and its potential neuroprotective mechanisms on the oxaliplatin-related peripheral sensory neuropathy in mice. Oxaliplatin (1 mg/kg) was injected intravenously in Swiss albino male mice twice a week (total of nine injections), while amifostine (1, 5, 25, 50, and 100 mg/kg) was administered subcutaneously 30 min before oxaliplatin. Mechanical and thermal nociceptive tests were performed once a week for 49 days. Additionally, c-Fos, nitrotyrosine, and activating transcription factor 3 (ATF3) immunoexpressions were assessed in the dorsal root ganglia. In all doses, amifostine prevented the development of mechanical hyperalgesia and thermal allodynia induced by oxaliplatin (P<0.05). Amifostine at the dose of 25 mg/kg provided the best protection (P<0.05). Moreover, amifostine protected against neuronal hyperactivation, nitrosative stress, and neuronal damage in the dorsal root ganglia, detected by the reduced expression of c-Fos, nitrotyrosine, and ATF3 (P<0.05 vs the oxaliplatin-treated group). In conclusion, amifostine reduced the nociception induced by oxaliplatin in mice, suggesting the possible use of amifostine for the management of oxaliplatin-induced peripheral sensory neuropathy.
publishDate 2020
dc.date.none.fl_str_mv 2020-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2020001100601
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2020001100601
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/1414-431x202010263
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
dc.source.none.fl_str_mv Brazilian Journal of Medical and Biological Research v.53 n.11 2020
reponame:Brazilian Journal of Medical and Biological Research
instname:Associação Brasileira de Divulgação Científica (ABDC)
instacron:ABDC
instname_str Associação Brasileira de Divulgação Científica (ABDC)
instacron_str ABDC
institution ABDC
reponame_str Brazilian Journal of Medical and Biological Research
collection Brazilian Journal of Medical and Biological Research
repository.name.fl_str_mv Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)
repository.mail.fl_str_mv bjournal@terra.com.br||bjournal@terra.com.br
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