Cytokines as determinants of disease and disease interactions
Autor(a) principal: | |
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Data de Publicação: | 1998 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Medical and Biological Research |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000100011 |
Resumo: | The immune response to pathogens results in both host resistance and immunopathology. Cytokines and in particular those lymphokines produced by Th1 and Th2 cells play a key role in determining the balance between these two immunologic outcomes. Recent data suggest that interleukin-10, a product of both Th2 cells and macrophages, protects the host against excessive immunopathology. The cytokine environment generated by different pathogens may also influence the course and outcome of infections with unrelated organisms. This relationship may be particularly important in the case of HIV-1 where prior Th1 or Th2 biases established by helminth or intracellular infections may influence either initial viral susceptibility or drive progression to AIDS through immune activation |
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Brazilian Journal of Medical and Biological Research |
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Cytokines as determinants of disease and disease interactionscytokinesdiseaseimmunopathologyHIV-Iparasites, interleukin-10The immune response to pathogens results in both host resistance and immunopathology. Cytokines and in particular those lymphokines produced by Th1 and Th2 cells play a key role in determining the balance between these two immunologic outcomes. Recent data suggest that interleukin-10, a product of both Th2 cells and macrophages, protects the host against excessive immunopathology. The cytokine environment generated by different pathogens may also influence the course and outcome of infections with unrelated organisms. This relationship may be particularly important in the case of HIV-1 where prior Th1 or Th2 biases established by helminth or intracellular infections may influence either initial viral susceptibility or drive progression to AIDS through immune activationAssociação Brasileira de Divulgação Científica1998-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000100011Brazilian Journal of Medical and Biological Research v.31 n.1 1998reponame:Brazilian Journal of Medical and Biological Researchinstname:Associação Brasileira de Divulgação Científica (ABDC)instacron:ABDC10.1590/S0100-879X1998000100011info:eu-repo/semantics/openAccessSher,A.Gazzinelli,R.T.Jankovic,D.Scharton-Kersten,T.Yap,G.Doherty,T.M.Wynn,T.eng1998-10-07T00:00:00Zoai:scielo:S0100-879X1998000100011Revistahttps://www.bjournal.org/https://old.scielo.br/oai/scielo-oai.phpbjournal@terra.com.br||bjournal@terra.com.br1414-431X0100-879Xopendoar:1998-10-07T00:00Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)false |
dc.title.none.fl_str_mv |
Cytokines as determinants of disease and disease interactions |
title |
Cytokines as determinants of disease and disease interactions |
spellingShingle |
Cytokines as determinants of disease and disease interactions Sher,A. cytokines disease immunopathology HIV-I parasites, interleukin-10 |
title_short |
Cytokines as determinants of disease and disease interactions |
title_full |
Cytokines as determinants of disease and disease interactions |
title_fullStr |
Cytokines as determinants of disease and disease interactions |
title_full_unstemmed |
Cytokines as determinants of disease and disease interactions |
title_sort |
Cytokines as determinants of disease and disease interactions |
author |
Sher,A. |
author_facet |
Sher,A. Gazzinelli,R.T. Jankovic,D. Scharton-Kersten,T. Yap,G. Doherty,T.M. Wynn,T. |
author_role |
author |
author2 |
Gazzinelli,R.T. Jankovic,D. Scharton-Kersten,T. Yap,G. Doherty,T.M. Wynn,T. |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Sher,A. Gazzinelli,R.T. Jankovic,D. Scharton-Kersten,T. Yap,G. Doherty,T.M. Wynn,T. |
dc.subject.por.fl_str_mv |
cytokines disease immunopathology HIV-I parasites, interleukin-10 |
topic |
cytokines disease immunopathology HIV-I parasites, interleukin-10 |
description |
The immune response to pathogens results in both host resistance and immunopathology. Cytokines and in particular those lymphokines produced by Th1 and Th2 cells play a key role in determining the balance between these two immunologic outcomes. Recent data suggest that interleukin-10, a product of both Th2 cells and macrophages, protects the host against excessive immunopathology. The cytokine environment generated by different pathogens may also influence the course and outcome of infections with unrelated organisms. This relationship may be particularly important in the case of HIV-1 where prior Th1 or Th2 biases established by helminth or intracellular infections may influence either initial viral susceptibility or drive progression to AIDS through immune activation |
publishDate |
1998 |
dc.date.none.fl_str_mv |
1998-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000100011 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000100011 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0100-879X1998000100011 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
dc.source.none.fl_str_mv |
Brazilian Journal of Medical and Biological Research v.31 n.1 1998 reponame:Brazilian Journal of Medical and Biological Research instname:Associação Brasileira de Divulgação Científica (ABDC) instacron:ABDC |
instname_str |
Associação Brasileira de Divulgação Científica (ABDC) |
instacron_str |
ABDC |
institution |
ABDC |
reponame_str |
Brazilian Journal of Medical and Biological Research |
collection |
Brazilian Journal of Medical and Biological Research |
repository.name.fl_str_mv |
Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC) |
repository.mail.fl_str_mv |
bjournal@terra.com.br||bjournal@terra.com.br |
_version_ |
1754302928916578304 |