Ca2+ signaling in pancreatic acinar cells: physiology and pathophysiology

Detalhes bibliográficos
Autor(a) principal: Petersen,O.H.
Data de Publicação: 2009
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Medical and Biological Research
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000100003
Resumo: The pancreatic acinar cell is a classical model for studies of secretion and signal transduction mechanisms. Because of the extensive endoplasmic reticulum and the large granular compartment, it has been possible - by direct measurements - to obtain considerable insights into intracellular Ca2+ handling under both normal and pathological conditions. Recent studies have also revealed important characteristics of stimulus-secretion coupling mechanisms in isolated human pancreatic acinar cells. The acinar cells are potentially dangerous because of the high intra-granular concentration of proteases, which become inappropriately activated in the human disease acute pancreatitis. This disease is due to toxic Ca2+ signals generated by excessive liberation of Ca2+ from both the endoplasmic reticulum and the secretory granules.
id ABDC-1_8bb7de1387e112c8300cd38cb38738c1
oai_identifier_str oai:scielo:S0100-879X2009000100003
network_acronym_str ABDC-1
network_name_str Brazilian Journal of Medical and Biological Research
repository_id_str
spelling Ca2+ signaling in pancreatic acinar cells: physiology and pathophysiologyCa2+ signalingPancreatic acinar cellsStimulus-secretion couplingHuman acinar cellsCa2+ entryCa2+ extrusionThe pancreatic acinar cell is a classical model for studies of secretion and signal transduction mechanisms. Because of the extensive endoplasmic reticulum and the large granular compartment, it has been possible - by direct measurements - to obtain considerable insights into intracellular Ca2+ handling under both normal and pathological conditions. Recent studies have also revealed important characteristics of stimulus-secretion coupling mechanisms in isolated human pancreatic acinar cells. The acinar cells are potentially dangerous because of the high intra-granular concentration of proteases, which become inappropriately activated in the human disease acute pancreatitis. This disease is due to toxic Ca2+ signals generated by excessive liberation of Ca2+ from both the endoplasmic reticulum and the secretory granules.Associação Brasileira de Divulgação Científica2009-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000100003Brazilian Journal of Medical and Biological Research v.42 n.1 2009reponame:Brazilian Journal of Medical and Biological Researchinstname:Associação Brasileira de Divulgação Científica (ABDC)instacron:ABDC10.1590/S0100-879X2009000100003info:eu-repo/semantics/openAccessPetersen,O.H.eng2009-02-12T00:00:00Zoai:scielo:S0100-879X2009000100003Revistahttps://www.bjournal.org/https://old.scielo.br/oai/scielo-oai.phpbjournal@terra.com.br||bjournal@terra.com.br1414-431X0100-879Xopendoar:2009-02-12T00:00Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)false
dc.title.none.fl_str_mv Ca2+ signaling in pancreatic acinar cells: physiology and pathophysiology
title Ca2+ signaling in pancreatic acinar cells: physiology and pathophysiology
spellingShingle Ca2+ signaling in pancreatic acinar cells: physiology and pathophysiology
Petersen,O.H.
Ca2+ signaling
Pancreatic acinar cells
Stimulus-secretion coupling
Human acinar cells
Ca2+ entry
Ca2+ extrusion
title_short Ca2+ signaling in pancreatic acinar cells: physiology and pathophysiology
title_full Ca2+ signaling in pancreatic acinar cells: physiology and pathophysiology
title_fullStr Ca2+ signaling in pancreatic acinar cells: physiology and pathophysiology
title_full_unstemmed Ca2+ signaling in pancreatic acinar cells: physiology and pathophysiology
title_sort Ca2+ signaling in pancreatic acinar cells: physiology and pathophysiology
author Petersen,O.H.
author_facet Petersen,O.H.
author_role author
dc.contributor.author.fl_str_mv Petersen,O.H.
dc.subject.por.fl_str_mv Ca2+ signaling
Pancreatic acinar cells
Stimulus-secretion coupling
Human acinar cells
Ca2+ entry
Ca2+ extrusion
topic Ca2+ signaling
Pancreatic acinar cells
Stimulus-secretion coupling
Human acinar cells
Ca2+ entry
Ca2+ extrusion
description The pancreatic acinar cell is a classical model for studies of secretion and signal transduction mechanisms. Because of the extensive endoplasmic reticulum and the large granular compartment, it has been possible - by direct measurements - to obtain considerable insights into intracellular Ca2+ handling under both normal and pathological conditions. Recent studies have also revealed important characteristics of stimulus-secretion coupling mechanisms in isolated human pancreatic acinar cells. The acinar cells are potentially dangerous because of the high intra-granular concentration of proteases, which become inappropriately activated in the human disease acute pancreatitis. This disease is due to toxic Ca2+ signals generated by excessive liberation of Ca2+ from both the endoplasmic reticulum and the secretory granules.
publishDate 2009
dc.date.none.fl_str_mv 2009-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000100003
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000100003
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0100-879X2009000100003
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
dc.source.none.fl_str_mv Brazilian Journal of Medical and Biological Research v.42 n.1 2009
reponame:Brazilian Journal of Medical and Biological Research
instname:Associação Brasileira de Divulgação Científica (ABDC)
instacron:ABDC
instname_str Associação Brasileira de Divulgação Científica (ABDC)
instacron_str ABDC
institution ABDC
reponame_str Brazilian Journal of Medical and Biological Research
collection Brazilian Journal of Medical and Biological Research
repository.name.fl_str_mv Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)
repository.mail.fl_str_mv bjournal@terra.com.br||bjournal@terra.com.br
_version_ 1754302936929796096

Registros relacionados