Extracellular matrix molecules play diverse roles in the growth and guidance of central nervous system axons
Autor(a) principal: | |
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Data de Publicação: | 1999 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Medical and Biological Research |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000500017 |
Resumo: | Axon growth and guidance represent complex biological processes in which probably intervene diverse sets of molecular cues that allow for the appropriate wiring of the central nervous system (CNS). The extracellular matrix (ECM) represents a major contributor of molecular signals either diffusible or membrane-bound that may regulate different stages of neural development. Some of the brain ECM molecules form tridimensional structures (tunnels and boundaries) that appear during time- and space-regulated events, possibly playing relevant roles in the control of axon elongation and pathfinding. This short review focuses mainly on the recognized roles played by proteoglycans, laminin, fibronectin and tenascin in axonal development during ontogenesis. |
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Brazilian Journal of Medical and Biological Research |
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Extracellular matrix molecules play diverse roles in the growth and guidance of central nervous system axonsaxon guidancedevelopmentanterior commissurecorpus callosumbrainAxon growth and guidance represent complex biological processes in which probably intervene diverse sets of molecular cues that allow for the appropriate wiring of the central nervous system (CNS). The extracellular matrix (ECM) represents a major contributor of molecular signals either diffusible or membrane-bound that may regulate different stages of neural development. Some of the brain ECM molecules form tridimensional structures (tunnels and boundaries) that appear during time- and space-regulated events, possibly playing relevant roles in the control of axon elongation and pathfinding. This short review focuses mainly on the recognized roles played by proteoglycans, laminin, fibronectin and tenascin in axonal development during ontogenesis.Associação Brasileira de Divulgação Científica1999-05-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000500017Brazilian Journal of Medical and Biological Research v.32 n.5 1999reponame:Brazilian Journal of Medical and Biological Researchinstname:Associação Brasileira de Divulgação Científica (ABDC)instacron:ABDC10.1590/S0100-879X1999000500017info:eu-repo/semantics/openAccessPires-Neto,M.A.Braga-de-Souza,S.Lent,R.eng1999-04-27T00:00:00Zoai:scielo:S0100-879X1999000500017Revistahttps://www.bjournal.org/https://old.scielo.br/oai/scielo-oai.phpbjournal@terra.com.br||bjournal@terra.com.br1414-431X0100-879Xopendoar:1999-04-27T00:00Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)false |
dc.title.none.fl_str_mv |
Extracellular matrix molecules play diverse roles in the growth and guidance of central nervous system axons |
title |
Extracellular matrix molecules play diverse roles in the growth and guidance of central nervous system axons |
spellingShingle |
Extracellular matrix molecules play diverse roles in the growth and guidance of central nervous system axons Pires-Neto,M.A. axon guidance development anterior commissure corpus callosum brain |
title_short |
Extracellular matrix molecules play diverse roles in the growth and guidance of central nervous system axons |
title_full |
Extracellular matrix molecules play diverse roles in the growth and guidance of central nervous system axons |
title_fullStr |
Extracellular matrix molecules play diverse roles in the growth and guidance of central nervous system axons |
title_full_unstemmed |
Extracellular matrix molecules play diverse roles in the growth and guidance of central nervous system axons |
title_sort |
Extracellular matrix molecules play diverse roles in the growth and guidance of central nervous system axons |
author |
Pires-Neto,M.A. |
author_facet |
Pires-Neto,M.A. Braga-de-Souza,S. Lent,R. |
author_role |
author |
author2 |
Braga-de-Souza,S. Lent,R. |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Pires-Neto,M.A. Braga-de-Souza,S. Lent,R. |
dc.subject.por.fl_str_mv |
axon guidance development anterior commissure corpus callosum brain |
topic |
axon guidance development anterior commissure corpus callosum brain |
description |
Axon growth and guidance represent complex biological processes in which probably intervene diverse sets of molecular cues that allow for the appropriate wiring of the central nervous system (CNS). The extracellular matrix (ECM) represents a major contributor of molecular signals either diffusible or membrane-bound that may regulate different stages of neural development. Some of the brain ECM molecules form tridimensional structures (tunnels and boundaries) that appear during time- and space-regulated events, possibly playing relevant roles in the control of axon elongation and pathfinding. This short review focuses mainly on the recognized roles played by proteoglycans, laminin, fibronectin and tenascin in axonal development during ontogenesis. |
publishDate |
1999 |
dc.date.none.fl_str_mv |
1999-05-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000500017 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000500017 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0100-879X1999000500017 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
dc.source.none.fl_str_mv |
Brazilian Journal of Medical and Biological Research v.32 n.5 1999 reponame:Brazilian Journal of Medical and Biological Research instname:Associação Brasileira de Divulgação Científica (ABDC) instacron:ABDC |
instname_str |
Associação Brasileira de Divulgação Científica (ABDC) |
instacron_str |
ABDC |
institution |
ABDC |
reponame_str |
Brazilian Journal of Medical and Biological Research |
collection |
Brazilian Journal of Medical and Biological Research |
repository.name.fl_str_mv |
Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC) |
repository.mail.fl_str_mv |
bjournal@terra.com.br||bjournal@terra.com.br |
_version_ |
1754302929966202880 |