Efficient retrovirus-mediated transfer of cell-cycle control genes to transformed cells

Detalhes bibliográficos
Autor(a) principal: Strauss,B.E.
Data de Publicação: 1999
Outros Autores: Costanzi-Strauss,E.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Medical and Biological Research
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000700016
Resumo: The use of gene therapy continues to be a promising, yet elusive, alternative for the treatment of cancer. The origins of cancer must be well understood so that the therapeutic gene can be chosen with the highest chance of successful tumor regression. The gene delivery system must be tailored for optimum transfer of the therapeutic gene to the target tissue. In order to accomplish this, we study models of G1 cell-cycle control in both normal and transformed cells in order to understand the reasons for uncontrolled cellular proliferation. We then use this information to choose the gene to be delivered to the cells. We have chosen to study p16, p21, p53 and pRb gene transfer using the pCL-retrovirus. Described here are some general concepts and specific results of our work that indicate continued hope for the development of genetically based cancer treatments.
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spelling Efficient retrovirus-mediated transfer of cell-cycle control genes to transformed cellsgene therapyclinical trialretrovirusanimal modelcell cyclegrowth arrestThe use of gene therapy continues to be a promising, yet elusive, alternative for the treatment of cancer. The origins of cancer must be well understood so that the therapeutic gene can be chosen with the highest chance of successful tumor regression. The gene delivery system must be tailored for optimum transfer of the therapeutic gene to the target tissue. In order to accomplish this, we study models of G1 cell-cycle control in both normal and transformed cells in order to understand the reasons for uncontrolled cellular proliferation. We then use this information to choose the gene to be delivered to the cells. We have chosen to study p16, p21, p53 and pRb gene transfer using the pCL-retrovirus. Described here are some general concepts and specific results of our work that indicate continued hope for the development of genetically based cancer treatments.Associação Brasileira de Divulgação Científica1999-07-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000700016Brazilian Journal of Medical and Biological Research v.32 n.7 1999reponame:Brazilian Journal of Medical and Biological Researchinstname:Associação Brasileira de Divulgação Científica (ABDC)instacron:ABDC10.1590/S0100-879X1999000700016info:eu-repo/semantics/openAccessStrauss,B.E.Costanzi-Strauss,E.eng1999-06-25T00:00:00Zoai:scielo:S0100-879X1999000700016Revistahttps://www.bjournal.org/https://old.scielo.br/oai/scielo-oai.phpbjournal@terra.com.br||bjournal@terra.com.br1414-431X0100-879Xopendoar:1999-06-25T00:00Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)false
dc.title.none.fl_str_mv Efficient retrovirus-mediated transfer of cell-cycle control genes to transformed cells
title Efficient retrovirus-mediated transfer of cell-cycle control genes to transformed cells
spellingShingle Efficient retrovirus-mediated transfer of cell-cycle control genes to transformed cells
Strauss,B.E.
gene therapy
clinical trial
retrovirus
animal model
cell cycle
growth arrest
title_short Efficient retrovirus-mediated transfer of cell-cycle control genes to transformed cells
title_full Efficient retrovirus-mediated transfer of cell-cycle control genes to transformed cells
title_fullStr Efficient retrovirus-mediated transfer of cell-cycle control genes to transformed cells
title_full_unstemmed Efficient retrovirus-mediated transfer of cell-cycle control genes to transformed cells
title_sort Efficient retrovirus-mediated transfer of cell-cycle control genes to transformed cells
author Strauss,B.E.
author_facet Strauss,B.E.
Costanzi-Strauss,E.
author_role author
author2 Costanzi-Strauss,E.
author2_role author
dc.contributor.author.fl_str_mv Strauss,B.E.
Costanzi-Strauss,E.
dc.subject.por.fl_str_mv gene therapy
clinical trial
retrovirus
animal model
cell cycle
growth arrest
topic gene therapy
clinical trial
retrovirus
animal model
cell cycle
growth arrest
description The use of gene therapy continues to be a promising, yet elusive, alternative for the treatment of cancer. The origins of cancer must be well understood so that the therapeutic gene can be chosen with the highest chance of successful tumor regression. The gene delivery system must be tailored for optimum transfer of the therapeutic gene to the target tissue. In order to accomplish this, we study models of G1 cell-cycle control in both normal and transformed cells in order to understand the reasons for uncontrolled cellular proliferation. We then use this information to choose the gene to be delivered to the cells. We have chosen to study p16, p21, p53 and pRb gene transfer using the pCL-retrovirus. Described here are some general concepts and specific results of our work that indicate continued hope for the development of genetically based cancer treatments.
publishDate 1999
dc.date.none.fl_str_mv 1999-07-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000700016
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000700016
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0100-879X1999000700016
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
dc.source.none.fl_str_mv Brazilian Journal of Medical and Biological Research v.32 n.7 1999
reponame:Brazilian Journal of Medical and Biological Research
instname:Associação Brasileira de Divulgação Científica (ABDC)
instacron:ABDC
instname_str Associação Brasileira de Divulgação Científica (ABDC)
instacron_str ABDC
institution ABDC
reponame_str Brazilian Journal of Medical and Biological Research
collection Brazilian Journal of Medical and Biological Research
repository.name.fl_str_mv Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)
repository.mail.fl_str_mv bjournal@terra.com.br||bjournal@terra.com.br
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