Topical application of a melanotropin analogue to vulgar vitiligo dermo-epidermal minigrafts
Autor(a) principal: | |
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Data de Publicação: | 1998 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Medical and Biological Research |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998001200008 |
Resumo: | Human subjects with active vulgar vitiligo do not respond well to autologous dermo-epidermal minigrafting. Eighteen subjects were treated with the <FONT FACE="Symbol">a</FONT>-melanocyte-stimulating hormone (<FONT FACE="Symbol">a</FONT>-MSH) synthetic analogue &#091;Nle4, D-Phe7&#093;-<FONT FACE="Symbol">a</FONT>-MSH. The hormone (50 µl, 0.4 mM) was applied topically to 30-cm2 lesions in which 29-48 minigrafts had been made. The hormone did not improve the success of the minigrafting and no differences were observed in local or distant repigmentation in treated subjects as compared to the placebo group. Aliquots of 24-h urine concentrated by lyophilization irreversibly darkened toad skins, demonstrating the presence of the analogue. This is the first report of the transdermal delivery of a topically applied melanotropin in living human subjects. |
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Brazilian Journal of Medical and Biological Research |
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|
spelling |
Topical application of a melanotropin analogue to vulgar vitiligo dermo-epidermal minigraftsvulgar vitiligo<FONT FACE=Symbol>a</FONT>-MSH synthetic analogueminigraftingHuman subjects with active vulgar vitiligo do not respond well to autologous dermo-epidermal minigrafting. Eighteen subjects were treated with the <FONT FACE="Symbol">a</FONT>-melanocyte-stimulating hormone (<FONT FACE="Symbol">a</FONT>-MSH) synthetic analogue &#091;Nle4, D-Phe7&#093;-<FONT FACE="Symbol">a</FONT>-MSH. The hormone (50 µl, 0.4 mM) was applied topically to 30-cm2 lesions in which 29-48 minigrafts had been made. The hormone did not improve the success of the minigrafting and no differences were observed in local or distant repigmentation in treated subjects as compared to the placebo group. Aliquots of 24-h urine concentrated by lyophilization irreversibly darkened toad skins, demonstrating the presence of the analogue. This is the first report of the transdermal delivery of a topically applied melanotropin in living human subjects.Associação Brasileira de Divulgação Científica1998-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998001200008Brazilian Journal of Medical and Biological Research v.31 n.12 1998reponame:Brazilian Journal of Medical and Biological Researchinstname:Associação Brasileira de Divulgação Científica (ABDC)instacron:ABDC10.1590/S0100-879X1998001200008info:eu-repo/semantics/openAccessSchwartzmann-Solon,A.M.Visconti,M.A.Castrucci,A.M.L.eng1998-12-08T00:00:00Zoai:scielo:S0100-879X1998001200008Revistahttps://www.bjournal.org/https://old.scielo.br/oai/scielo-oai.phpbjournal@terra.com.br||bjournal@terra.com.br1414-431X0100-879Xopendoar:1998-12-08T00:00Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)false |
dc.title.none.fl_str_mv |
Topical application of a melanotropin analogue to vulgar vitiligo dermo-epidermal minigrafts |
title |
Topical application of a melanotropin analogue to vulgar vitiligo dermo-epidermal minigrafts |
spellingShingle |
Topical application of a melanotropin analogue to vulgar vitiligo dermo-epidermal minigrafts Schwartzmann-Solon,A.M. vulgar vitiligo <FONT FACE=Symbol>a</FONT>-MSH synthetic analogue minigrafting |
title_short |
Topical application of a melanotropin analogue to vulgar vitiligo dermo-epidermal minigrafts |
title_full |
Topical application of a melanotropin analogue to vulgar vitiligo dermo-epidermal minigrafts |
title_fullStr |
Topical application of a melanotropin analogue to vulgar vitiligo dermo-epidermal minigrafts |
title_full_unstemmed |
Topical application of a melanotropin analogue to vulgar vitiligo dermo-epidermal minigrafts |
title_sort |
Topical application of a melanotropin analogue to vulgar vitiligo dermo-epidermal minigrafts |
author |
Schwartzmann-Solon,A.M. |
author_facet |
Schwartzmann-Solon,A.M. Visconti,M.A. Castrucci,A.M.L. |
author_role |
author |
author2 |
Visconti,M.A. Castrucci,A.M.L. |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Schwartzmann-Solon,A.M. Visconti,M.A. Castrucci,A.M.L. |
dc.subject.por.fl_str_mv |
vulgar vitiligo <FONT FACE=Symbol>a</FONT>-MSH synthetic analogue minigrafting |
topic |
vulgar vitiligo <FONT FACE=Symbol>a</FONT>-MSH synthetic analogue minigrafting |
description |
Human subjects with active vulgar vitiligo do not respond well to autologous dermo-epidermal minigrafting. Eighteen subjects were treated with the <FONT FACE="Symbol">a</FONT>-melanocyte-stimulating hormone (<FONT FACE="Symbol">a</FONT>-MSH) synthetic analogue &#091;Nle4, D-Phe7&#093;-<FONT FACE="Symbol">a</FONT>-MSH. The hormone (50 µl, 0.4 mM) was applied topically to 30-cm2 lesions in which 29-48 minigrafts had been made. The hormone did not improve the success of the minigrafting and no differences were observed in local or distant repigmentation in treated subjects as compared to the placebo group. Aliquots of 24-h urine concentrated by lyophilization irreversibly darkened toad skins, demonstrating the presence of the analogue. This is the first report of the transdermal delivery of a topically applied melanotropin in living human subjects. |
publishDate |
1998 |
dc.date.none.fl_str_mv |
1998-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998001200008 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998001200008 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0100-879X1998001200008 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
dc.source.none.fl_str_mv |
Brazilian Journal of Medical and Biological Research v.31 n.12 1998 reponame:Brazilian Journal of Medical and Biological Research instname:Associação Brasileira de Divulgação Científica (ABDC) instacron:ABDC |
instname_str |
Associação Brasileira de Divulgação Científica (ABDC) |
instacron_str |
ABDC |
institution |
ABDC |
reponame_str |
Brazilian Journal of Medical and Biological Research |
collection |
Brazilian Journal of Medical and Biological Research |
repository.name.fl_str_mv |
Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC) |
repository.mail.fl_str_mv |
bjournal@terra.com.br||bjournal@terra.com.br |
_version_ |
1754302929629609984 |