Subacute combined degeneration of the spinal cord with concomitant autoimmune disease: report of 2 cases
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , |
Tipo de documento: | Relatório |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Medical and Biological Research |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2021001000501 |
Resumo: | The etiology of subacute combined degeneration (SCD) of the spinal cord is closely associated with vitamin B12 (VitB12) deficiency. The clinical manifestations of SCD are complex and vary substantially. Due to some SCD patients with atypical manifestations and concomitant autoimmune disorders, the probability of misdiagnosis and missed diagnosis is still relatively high in the early stage. We report the cases of two patients who were missed or misdiagnosed at another hospital because of the normal initial VitB12 level and partial overlap of clinical manifestations, finally diagnosed as SCD with atypical manifestations and concomitant autoimmune disorders, pharyngeal-cervical-brachial Guillain-Barre syndrome in Case 1 and SCD with autoimmune thyroiditis in Case 2. After undergoing corresponding treatment, death was reported in Case 1 and improvement in Case 2. Analysis of the clinical manifestations and investigation of the underlying pathogenesis in such patients could help improve the rate of early diagnosis and allow timely treatment of SCD, thereby preventing disease progression and poor clinical outcomes. |
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Brazilian Journal of Medical and Biological Research |
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Subacute combined degeneration of the spinal cord with concomitant autoimmune disease: report of 2 casesSubacute combined degeneration of spinal cordVitamin B12Anti-intrinsic factor antibodyAutoimmune diseaseCase reportThe etiology of subacute combined degeneration (SCD) of the spinal cord is closely associated with vitamin B12 (VitB12) deficiency. The clinical manifestations of SCD are complex and vary substantially. Due to some SCD patients with atypical manifestations and concomitant autoimmune disorders, the probability of misdiagnosis and missed diagnosis is still relatively high in the early stage. We report the cases of two patients who were missed or misdiagnosed at another hospital because of the normal initial VitB12 level and partial overlap of clinical manifestations, finally diagnosed as SCD with atypical manifestations and concomitant autoimmune disorders, pharyngeal-cervical-brachial Guillain-Barre syndrome in Case 1 and SCD with autoimmune thyroiditis in Case 2. After undergoing corresponding treatment, death was reported in Case 1 and improvement in Case 2. Analysis of the clinical manifestations and investigation of the underlying pathogenesis in such patients could help improve the rate of early diagnosis and allow timely treatment of SCD, thereby preventing disease progression and poor clinical outcomes.Associação Brasileira de Divulgação Científica2021-01-01info:eu-repo/semantics/reportinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2021001000501Brazilian Journal of Medical and Biological Research v.54 n.10 2021reponame:Brazilian Journal of Medical and Biological Researchinstname:Associação Brasileira de Divulgação Científica (ABDC)instacron:ABDC10.1590/1414-431x2021e11355info:eu-repo/semantics/openAccessJiang,Tian-FangZheng,JiaChen,Xueng2021-07-13T00:00:00Zoai:scielo:S0100-879X2021001000501Revistahttps://www.bjournal.org/https://old.scielo.br/oai/scielo-oai.phpbjournal@terra.com.br||bjournal@terra.com.br1414-431X0100-879Xopendoar:2021-07-13T00:00Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)false |
dc.title.none.fl_str_mv |
Subacute combined degeneration of the spinal cord with concomitant autoimmune disease: report of 2 cases |
title |
Subacute combined degeneration of the spinal cord with concomitant autoimmune disease: report of 2 cases |
spellingShingle |
Subacute combined degeneration of the spinal cord with concomitant autoimmune disease: report of 2 cases Jiang,Tian-Fang Subacute combined degeneration of spinal cord Vitamin B12 Anti-intrinsic factor antibody Autoimmune disease Case report |
title_short |
Subacute combined degeneration of the spinal cord with concomitant autoimmune disease: report of 2 cases |
title_full |
Subacute combined degeneration of the spinal cord with concomitant autoimmune disease: report of 2 cases |
title_fullStr |
Subacute combined degeneration of the spinal cord with concomitant autoimmune disease: report of 2 cases |
title_full_unstemmed |
Subacute combined degeneration of the spinal cord with concomitant autoimmune disease: report of 2 cases |
title_sort |
Subacute combined degeneration of the spinal cord with concomitant autoimmune disease: report of 2 cases |
author |
Jiang,Tian-Fang |
author_facet |
Jiang,Tian-Fang Zheng,Jia Chen,Xu |
author_role |
author |
author2 |
Zheng,Jia Chen,Xu |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Jiang,Tian-Fang Zheng,Jia Chen,Xu |
dc.subject.por.fl_str_mv |
Subacute combined degeneration of spinal cord Vitamin B12 Anti-intrinsic factor antibody Autoimmune disease Case report |
topic |
Subacute combined degeneration of spinal cord Vitamin B12 Anti-intrinsic factor antibody Autoimmune disease Case report |
description |
The etiology of subacute combined degeneration (SCD) of the spinal cord is closely associated with vitamin B12 (VitB12) deficiency. The clinical manifestations of SCD are complex and vary substantially. Due to some SCD patients with atypical manifestations and concomitant autoimmune disorders, the probability of misdiagnosis and missed diagnosis is still relatively high in the early stage. We report the cases of two patients who were missed or misdiagnosed at another hospital because of the normal initial VitB12 level and partial overlap of clinical manifestations, finally diagnosed as SCD with atypical manifestations and concomitant autoimmune disorders, pharyngeal-cervical-brachial Guillain-Barre syndrome in Case 1 and SCD with autoimmune thyroiditis in Case 2. After undergoing corresponding treatment, death was reported in Case 1 and improvement in Case 2. Analysis of the clinical manifestations and investigation of the underlying pathogenesis in such patients could help improve the rate of early diagnosis and allow timely treatment of SCD, thereby preventing disease progression and poor clinical outcomes. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/report |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
report |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2021001000501 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2021001000501 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1414-431x2021e11355 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
dc.source.none.fl_str_mv |
Brazilian Journal of Medical and Biological Research v.54 n.10 2021 reponame:Brazilian Journal of Medical and Biological Research instname:Associação Brasileira de Divulgação Científica (ABDC) instacron:ABDC |
instname_str |
Associação Brasileira de Divulgação Científica (ABDC) |
instacron_str |
ABDC |
institution |
ABDC |
reponame_str |
Brazilian Journal of Medical and Biological Research |
collection |
Brazilian Journal of Medical and Biological Research |
repository.name.fl_str_mv |
Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC) |
repository.mail.fl_str_mv |
bjournal@terra.com.br||bjournal@terra.com.br |
_version_ |
1754302948533338112 |