Treatment of bladder dysfunction with solifenacin: is there a risk of dementia or cognitive impairment?
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Medical and Biological Research |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2022000100302 |
Resumo: | The use of bladder antimuscarinics is very common in the elderly. However, recent population-based studies that assessed the use of anticholinergics or bladder antimuscarinics showed an increased risk of dementia when these drugs were used for a prolonged period. Several of these population-based studies included patients who used solifenacin, which is a bladder antimuscarinic released in 2005 with the prospect of being a more selective antimuscarinic for M3 receptors (M3R), which could make it a safer drug when trying to avoid unwanted effects of older bladder antimuscarinics such as oxybutynin, especially with regard to changes in cognition. Since the various bladder antimuscarinics have distinct pharmacological characteristics, such as in the ability to penetrate the blood-brain barrier, in selectivity for muscarinic receptors, and in brain efflux mechanisms, their effects on the central nervous system (CNS) may vary. Solifenacin was the drug selected in this review, which aims to describe the results of several articles published in recent years reporting the effects of solifenacin on cognition or the risk of dementia development. Although preclinical studies show that solifenacin can also act on brain M1 receptors (M1R), short-term clinical studies have shown it to be safe for cognition. However, there are no long-term randomized studies that prove the safety of this drug for the CNS. Thus, until the safety of solifenacin has been established by long-term studies, it seems advisable to avoid prolonged use of this drug in elderly patients. |
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Treatment of bladder dysfunction with solifenacin: is there a risk of dementia or cognitive impairment?SolifenacinDementiaCognitive impairmentAnticholinergicsBladder antimuscarinicsThe use of bladder antimuscarinics is very common in the elderly. However, recent population-based studies that assessed the use of anticholinergics or bladder antimuscarinics showed an increased risk of dementia when these drugs were used for a prolonged period. Several of these population-based studies included patients who used solifenacin, which is a bladder antimuscarinic released in 2005 with the prospect of being a more selective antimuscarinic for M3 receptors (M3R), which could make it a safer drug when trying to avoid unwanted effects of older bladder antimuscarinics such as oxybutynin, especially with regard to changes in cognition. Since the various bladder antimuscarinics have distinct pharmacological characteristics, such as in the ability to penetrate the blood-brain barrier, in selectivity for muscarinic receptors, and in brain efflux mechanisms, their effects on the central nervous system (CNS) may vary. Solifenacin was the drug selected in this review, which aims to describe the results of several articles published in recent years reporting the effects of solifenacin on cognition or the risk of dementia development. Although preclinical studies show that solifenacin can also act on brain M1 receptors (M1R), short-term clinical studies have shown it to be safe for cognition. However, there are no long-term randomized studies that prove the safety of this drug for the CNS. Thus, until the safety of solifenacin has been established by long-term studies, it seems advisable to avoid prolonged use of this drug in elderly patients.Associação Brasileira de Divulgação Científica2022-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2022000100302Brazilian Journal of Medical and Biological Research v.55 2022reponame:Brazilian Journal of Medical and Biological Researchinstname:Associação Brasileira de Divulgação Científica (ABDC)instacron:ABDC10.1590/1414-431x2021e11721info:eu-repo/semantics/openAccessDantas,L.P.Forte,A.R.C.C.Lima,B.C.Sousa,C.N.S.Vasconcelos,E.C.Lessa,P.H.C.Vieira,R.F.Patrocínio,M.C.A.Vasconcelos,S.M.M.eng2022-02-01T00:00:00Zoai:scielo:S0100-879X2022000100302Revistahttps://www.bjournal.org/https://old.scielo.br/oai/scielo-oai.phpbjournal@terra.com.br||bjournal@terra.com.br1414-431X0100-879Xopendoar:2022-02-01T00:00Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)false |
dc.title.none.fl_str_mv |
Treatment of bladder dysfunction with solifenacin: is there a risk of dementia or cognitive impairment? |
title |
Treatment of bladder dysfunction with solifenacin: is there a risk of dementia or cognitive impairment? |
spellingShingle |
Treatment of bladder dysfunction with solifenacin: is there a risk of dementia or cognitive impairment? Dantas,L.P. Solifenacin Dementia Cognitive impairment Anticholinergics Bladder antimuscarinics |
title_short |
Treatment of bladder dysfunction with solifenacin: is there a risk of dementia or cognitive impairment? |
title_full |
Treatment of bladder dysfunction with solifenacin: is there a risk of dementia or cognitive impairment? |
title_fullStr |
Treatment of bladder dysfunction with solifenacin: is there a risk of dementia or cognitive impairment? |
title_full_unstemmed |
Treatment of bladder dysfunction with solifenacin: is there a risk of dementia or cognitive impairment? |
title_sort |
Treatment of bladder dysfunction with solifenacin: is there a risk of dementia or cognitive impairment? |
author |
Dantas,L.P. |
author_facet |
Dantas,L.P. Forte,A.R.C.C. Lima,B.C. Sousa,C.N.S. Vasconcelos,E.C. Lessa,P.H.C. Vieira,R.F. Patrocínio,M.C.A. Vasconcelos,S.M.M. |
author_role |
author |
author2 |
Forte,A.R.C.C. Lima,B.C. Sousa,C.N.S. Vasconcelos,E.C. Lessa,P.H.C. Vieira,R.F. Patrocínio,M.C.A. Vasconcelos,S.M.M. |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Dantas,L.P. Forte,A.R.C.C. Lima,B.C. Sousa,C.N.S. Vasconcelos,E.C. Lessa,P.H.C. Vieira,R.F. Patrocínio,M.C.A. Vasconcelos,S.M.M. |
dc.subject.por.fl_str_mv |
Solifenacin Dementia Cognitive impairment Anticholinergics Bladder antimuscarinics |
topic |
Solifenacin Dementia Cognitive impairment Anticholinergics Bladder antimuscarinics |
description |
The use of bladder antimuscarinics is very common in the elderly. However, recent population-based studies that assessed the use of anticholinergics or bladder antimuscarinics showed an increased risk of dementia when these drugs were used for a prolonged period. Several of these population-based studies included patients who used solifenacin, which is a bladder antimuscarinic released in 2005 with the prospect of being a more selective antimuscarinic for M3 receptors (M3R), which could make it a safer drug when trying to avoid unwanted effects of older bladder antimuscarinics such as oxybutynin, especially with regard to changes in cognition. Since the various bladder antimuscarinics have distinct pharmacological characteristics, such as in the ability to penetrate the blood-brain barrier, in selectivity for muscarinic receptors, and in brain efflux mechanisms, their effects on the central nervous system (CNS) may vary. Solifenacin was the drug selected in this review, which aims to describe the results of several articles published in recent years reporting the effects of solifenacin on cognition or the risk of dementia development. Although preclinical studies show that solifenacin can also act on brain M1 receptors (M1R), short-term clinical studies have shown it to be safe for cognition. However, there are no long-term randomized studies that prove the safety of this drug for the CNS. Thus, until the safety of solifenacin has been established by long-term studies, it seems advisable to avoid prolonged use of this drug in elderly patients. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2022000100302 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2022000100302 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1414-431x2021e11721 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
dc.source.none.fl_str_mv |
Brazilian Journal of Medical and Biological Research v.55 2022 reponame:Brazilian Journal of Medical and Biological Research instname:Associação Brasileira de Divulgação Científica (ABDC) instacron:ABDC |
instname_str |
Associação Brasileira de Divulgação Científica (ABDC) |
instacron_str |
ABDC |
institution |
ABDC |
reponame_str |
Brazilian Journal of Medical and Biological Research |
collection |
Brazilian Journal of Medical and Biological Research |
repository.name.fl_str_mv |
Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC) |
repository.mail.fl_str_mv |
bjournal@terra.com.br||bjournal@terra.com.br |
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1754302948881465344 |