Evasion of immune responses by Trypanosoma cruzi, the etiological agent of Chagas disease
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Medical and Biological Research |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000200001 |
Resumo: | Infection with the protozoan parasite Trypanosoma cruzi leads to Chagas disease, which affects millions of people in Latin America. Infection with T. cruzi cannot be eliminated by the immune system. A better understanding of immune evasion mechanisms is required in order to develop more effective vaccines. During the acute phase, parasites replicate extensively and release immunomodulatory molecules that delay parasite-specific responses mediated by T cells. This immune evasion allows the parasite to spread in the host. In the chronic phase, parasite evasion relies on its replication strategy of hijacking the TGF-β signaling pathway involved in inflammation and tissue regeneration. In this article, the mechanisms of immune evasion described for T. cruzi are reviewed. |
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Brazilian Journal of Medical and Biological Research |
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Evasion of immune responses by Trypanosoma cruzi, the etiological agent of Chagas diseaseTrypanosoma cruziT cellsGPI-anchorsTGF-βMucinApoptosisInfection with the protozoan parasite Trypanosoma cruzi leads to Chagas disease, which affects millions of people in Latin America. Infection with T. cruzi cannot be eliminated by the immune system. A better understanding of immune evasion mechanisms is required in order to develop more effective vaccines. During the acute phase, parasites replicate extensively and release immunomodulatory molecules that delay parasite-specific responses mediated by T cells. This immune evasion allows the parasite to spread in the host. In the chronic phase, parasite evasion relies on its replication strategy of hijacking the TGF-β signaling pathway involved in inflammation and tissue regeneration. In this article, the mechanisms of immune evasion described for T. cruzi are reviewed.Associação Brasileira de Divulgação Científica2011-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000200001Brazilian Journal of Medical and Biological Research v.44 n.2 2011reponame:Brazilian Journal of Medical and Biological Researchinstname:Associação Brasileira de Divulgação Científica (ABDC)instacron:ABDC10.1590/S0100-879X2011007500005info:eu-repo/semantics/openAccessDosReis,G.A.eng2011-02-04T00:00:00Zoai:scielo:S0100-879X2011000200001Revistahttps://www.bjournal.org/https://old.scielo.br/oai/scielo-oai.phpbjournal@terra.com.br||bjournal@terra.com.br1414-431X0100-879Xopendoar:2011-02-04T00:00Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)false |
dc.title.none.fl_str_mv |
Evasion of immune responses by Trypanosoma cruzi, the etiological agent of Chagas disease |
title |
Evasion of immune responses by Trypanosoma cruzi, the etiological agent of Chagas disease |
spellingShingle |
Evasion of immune responses by Trypanosoma cruzi, the etiological agent of Chagas disease DosReis,G.A. Trypanosoma cruzi T cells GPI-anchors TGF-β Mucin Apoptosis |
title_short |
Evasion of immune responses by Trypanosoma cruzi, the etiological agent of Chagas disease |
title_full |
Evasion of immune responses by Trypanosoma cruzi, the etiological agent of Chagas disease |
title_fullStr |
Evasion of immune responses by Trypanosoma cruzi, the etiological agent of Chagas disease |
title_full_unstemmed |
Evasion of immune responses by Trypanosoma cruzi, the etiological agent of Chagas disease |
title_sort |
Evasion of immune responses by Trypanosoma cruzi, the etiological agent of Chagas disease |
author |
DosReis,G.A. |
author_facet |
DosReis,G.A. |
author_role |
author |
dc.contributor.author.fl_str_mv |
DosReis,G.A. |
dc.subject.por.fl_str_mv |
Trypanosoma cruzi T cells GPI-anchors TGF-β Mucin Apoptosis |
topic |
Trypanosoma cruzi T cells GPI-anchors TGF-β Mucin Apoptosis |
description |
Infection with the protozoan parasite Trypanosoma cruzi leads to Chagas disease, which affects millions of people in Latin America. Infection with T. cruzi cannot be eliminated by the immune system. A better understanding of immune evasion mechanisms is required in order to develop more effective vaccines. During the acute phase, parasites replicate extensively and release immunomodulatory molecules that delay parasite-specific responses mediated by T cells. This immune evasion allows the parasite to spread in the host. In the chronic phase, parasite evasion relies on its replication strategy of hijacking the TGF-β signaling pathway involved in inflammation and tissue regeneration. In this article, the mechanisms of immune evasion described for T. cruzi are reviewed. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-02-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000200001 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000200001 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0100-879X2011007500005 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
dc.source.none.fl_str_mv |
Brazilian Journal of Medical and Biological Research v.44 n.2 2011 reponame:Brazilian Journal of Medical and Biological Research instname:Associação Brasileira de Divulgação Científica (ABDC) instacron:ABDC |
instname_str |
Associação Brasileira de Divulgação Científica (ABDC) |
instacron_str |
ABDC |
institution |
ABDC |
reponame_str |
Brazilian Journal of Medical and Biological Research |
collection |
Brazilian Journal of Medical and Biological Research |
repository.name.fl_str_mv |
Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC) |
repository.mail.fl_str_mv |
bjournal@terra.com.br||bjournal@terra.com.br |
_version_ |
1754302939911946240 |