Noninvasive assessment of endothelial function and ST segment changes during exercise testing in coronary artery disease

Detalhes bibliográficos
Autor(a) principal: Chequer,G.
Data de Publicação: 2009
Outros Autores: Navarro,T.P., Nascimento,B.R., Falqueto,E.B., Nascimento,D.C., Alencar,M.C.N., Mandil,A., Saad,J.A., Fonseca,C.P., Ribeiro,A.L.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Medical and Biological Research
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000500003
Resumo: Endothelial function (EF) plays an important role in the onset and clinical course of atherosclerosis, although its relationship with the presence and extent of coronary artery disease (CAD) has not been well defined. We evaluated EF and the ST segment response to an exercise test in patients with a broad spectrum of CAD defined by coronary angiography. Sixty-two patients submitted to diagnostic catheterization for the evaluation of chest pain or ischemia in a provocative test were divided into three groups according to the presence and severity of atherosclerotic lesions (AL): group 1: normal coronaries (N = 19); group 2: CAD with AL <70% (N = 17); group 3: CAD with AL ≥70% (N = 26). EF was evaluated by the percentage of flow-mediated dilatation (%FMD) in the brachial artery during reactive hyperemia induced by occlusion of the forearm with a pneumatic cuff for 5 min. Fifty-four patients were subjected to an exercise test. Gender and age were not significantly correlated with %FMD. EF was markedly reduced in both groups with CAD (76.5 and 73.1% vs 31.6% in group 1) and a higher frequency of ischemic alterations in the ST segment (70.8%) was observed in the group with obstructive CAD with AL ≥70% during the exercise test. Endothelial dysfunction was observed in patients with CAD, irrespective of the severity of injury. A significantly higher frequency of ischemic alterations in the ST segment was observed in the group with obstructive CAD. EF and exercise ECG differed among the three groups and may provide complementary information for the assessment of CAD.
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spelling Noninvasive assessment of endothelial function and ST segment changes during exercise testing in coronary artery diseaseCoronary artery diseaseEndothelial functionExercise testingEndothelial function (EF) plays an important role in the onset and clinical course of atherosclerosis, although its relationship with the presence and extent of coronary artery disease (CAD) has not been well defined. We evaluated EF and the ST segment response to an exercise test in patients with a broad spectrum of CAD defined by coronary angiography. Sixty-two patients submitted to diagnostic catheterization for the evaluation of chest pain or ischemia in a provocative test were divided into three groups according to the presence and severity of atherosclerotic lesions (AL): group 1: normal coronaries (N = 19); group 2: CAD with AL <70% (N = 17); group 3: CAD with AL ≥70% (N = 26). EF was evaluated by the percentage of flow-mediated dilatation (%FMD) in the brachial artery during reactive hyperemia induced by occlusion of the forearm with a pneumatic cuff for 5 min. Fifty-four patients were subjected to an exercise test. Gender and age were not significantly correlated with %FMD. EF was markedly reduced in both groups with CAD (76.5 and 73.1% vs 31.6% in group 1) and a higher frequency of ischemic alterations in the ST segment (70.8%) was observed in the group with obstructive CAD with AL ≥70% during the exercise test. Endothelial dysfunction was observed in patients with CAD, irrespective of the severity of injury. A significantly higher frequency of ischemic alterations in the ST segment was observed in the group with obstructive CAD. EF and exercise ECG differed among the three groups and may provide complementary information for the assessment of CAD.Associação Brasileira de Divulgação Científica2009-05-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000500003Brazilian Journal of Medical and Biological Research v.42 n.5 2009reponame:Brazilian Journal of Medical and Biological Researchinstname:Associação Brasileira de Divulgação Científica (ABDC)instacron:ABDC10.1590/S0100-879X2009000500003info:eu-repo/semantics/openAccessChequer,G.Navarro,T.P.Nascimento,B.R.Falqueto,E.B.Nascimento,D.C.Alencar,M.C.N.Mandil,A.Saad,J.A.Fonseca,C.P.Ribeiro,A.L.eng2009-04-13T00:00:00Zoai:scielo:S0100-879X2009000500003Revistahttps://www.bjournal.org/https://old.scielo.br/oai/scielo-oai.phpbjournal@terra.com.br||bjournal@terra.com.br1414-431X0100-879Xopendoar:2009-04-13T00:00Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)false
dc.title.none.fl_str_mv Noninvasive assessment of endothelial function and ST segment changes during exercise testing in coronary artery disease
title Noninvasive assessment of endothelial function and ST segment changes during exercise testing in coronary artery disease
spellingShingle Noninvasive assessment of endothelial function and ST segment changes during exercise testing in coronary artery disease
Chequer,G.
Coronary artery disease
Endothelial function
Exercise testing
title_short Noninvasive assessment of endothelial function and ST segment changes during exercise testing in coronary artery disease
title_full Noninvasive assessment of endothelial function and ST segment changes during exercise testing in coronary artery disease
title_fullStr Noninvasive assessment of endothelial function and ST segment changes during exercise testing in coronary artery disease
title_full_unstemmed Noninvasive assessment of endothelial function and ST segment changes during exercise testing in coronary artery disease
title_sort Noninvasive assessment of endothelial function and ST segment changes during exercise testing in coronary artery disease
author Chequer,G.
author_facet Chequer,G.
Navarro,T.P.
Nascimento,B.R.
Falqueto,E.B.
Nascimento,D.C.
Alencar,M.C.N.
Mandil,A.
Saad,J.A.
Fonseca,C.P.
Ribeiro,A.L.
author_role author
author2 Navarro,T.P.
Nascimento,B.R.
Falqueto,E.B.
Nascimento,D.C.
Alencar,M.C.N.
Mandil,A.
Saad,J.A.
Fonseca,C.P.
Ribeiro,A.L.
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Chequer,G.
Navarro,T.P.
Nascimento,B.R.
Falqueto,E.B.
Nascimento,D.C.
Alencar,M.C.N.
Mandil,A.
Saad,J.A.
Fonseca,C.P.
Ribeiro,A.L.
dc.subject.por.fl_str_mv Coronary artery disease
Endothelial function
Exercise testing
topic Coronary artery disease
Endothelial function
Exercise testing
description Endothelial function (EF) plays an important role in the onset and clinical course of atherosclerosis, although its relationship with the presence and extent of coronary artery disease (CAD) has not been well defined. We evaluated EF and the ST segment response to an exercise test in patients with a broad spectrum of CAD defined by coronary angiography. Sixty-two patients submitted to diagnostic catheterization for the evaluation of chest pain or ischemia in a provocative test were divided into three groups according to the presence and severity of atherosclerotic lesions (AL): group 1: normal coronaries (N = 19); group 2: CAD with AL <70% (N = 17); group 3: CAD with AL ≥70% (N = 26). EF was evaluated by the percentage of flow-mediated dilatation (%FMD) in the brachial artery during reactive hyperemia induced by occlusion of the forearm with a pneumatic cuff for 5 min. Fifty-four patients were subjected to an exercise test. Gender and age were not significantly correlated with %FMD. EF was markedly reduced in both groups with CAD (76.5 and 73.1% vs 31.6% in group 1) and a higher frequency of ischemic alterations in the ST segment (70.8%) was observed in the group with obstructive CAD with AL ≥70% during the exercise test. Endothelial dysfunction was observed in patients with CAD, irrespective of the severity of injury. A significantly higher frequency of ischemic alterations in the ST segment was observed in the group with obstructive CAD. EF and exercise ECG differed among the three groups and may provide complementary information for the assessment of CAD.
publishDate 2009
dc.date.none.fl_str_mv 2009-05-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000500003
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000500003
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0100-879X2009000500003
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
dc.source.none.fl_str_mv Brazilian Journal of Medical and Biological Research v.42 n.5 2009
reponame:Brazilian Journal of Medical and Biological Research
instname:Associação Brasileira de Divulgação Científica (ABDC)
instacron:ABDC
instname_str Associação Brasileira de Divulgação Científica (ABDC)
instacron_str ABDC
institution ABDC
reponame_str Brazilian Journal of Medical and Biological Research
collection Brazilian Journal of Medical and Biological Research
repository.name.fl_str_mv Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)
repository.mail.fl_str_mv bjournal@terra.com.br||bjournal@terra.com.br
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