Human papillomavirus detection and p16 methylation pattern in a case of esophageal papilloma

Detalhes bibliográficos
Autor(a) principal: Afonso,L.A.
Data de Publicação: 2010
Outros Autores: Moysés,N., Cavalcanti,S.M.B.
Tipo de documento: Relatório
Idioma: eng
Título da fonte: Brazilian Journal of Medical and Biological Research
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000700013
Resumo: Esophageal cancer is a prevalent cancer worldwide. Some studies have reported the possible etiology of human papillomavirus (HPV) in benign and malignant papillomas of the esophagus but the conclusions are controversial. In the present study, we investigated an esophageal papilloma from a 30-year-old male patient presenting aphasia. HPV DNA was detected by generic PCR using MY09/11 primers, and restriction fragment length polymorphism revealed the presence of HPV54, usually associated with benign genital lesions. Hypermethylation of the pINK4A gene was also investigated due to its relation to malignant transformation, but no modification was detected in the host gene. Except for an incipient reflux, no risk factors such as cigarette smoking, alcohol abuse or an infected sexual partner were recorded. Since esophageal lesions may have a malignant potential, HPV detection and typing are useful tools for patient follow-up.
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spelling Human papillomavirus detection and p16 methylation pattern in a case of esophageal papillomaHuman papillomavirusEsophageal cancerRestriction fragment length polymorphismEsophageal cancer is a prevalent cancer worldwide. Some studies have reported the possible etiology of human papillomavirus (HPV) in benign and malignant papillomas of the esophagus but the conclusions are controversial. In the present study, we investigated an esophageal papilloma from a 30-year-old male patient presenting aphasia. HPV DNA was detected by generic PCR using MY09/11 primers, and restriction fragment length polymorphism revealed the presence of HPV54, usually associated with benign genital lesions. Hypermethylation of the pINK4A gene was also investigated due to its relation to malignant transformation, but no modification was detected in the host gene. Except for an incipient reflux, no risk factors such as cigarette smoking, alcohol abuse or an infected sexual partner were recorded. Since esophageal lesions may have a malignant potential, HPV detection and typing are useful tools for patient follow-up.Associação Brasileira de Divulgação Científica2010-07-01info:eu-repo/semantics/reportinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000700013Brazilian Journal of Medical and Biological Research v.43 n.7 2010reponame:Brazilian Journal of Medical and Biological Researchinstname:Associação Brasileira de Divulgação Científica (ABDC)instacron:ABDC10.1590/S0100-879X2010007500055info:eu-repo/semantics/openAccessAfonso,L.A.Moysés,N.Cavalcanti,S.M.B.eng2010-07-02T00:00:00Zoai:scielo:S0100-879X2010000700013Revistahttps://www.bjournal.org/https://old.scielo.br/oai/scielo-oai.phpbjournal@terra.com.br||bjournal@terra.com.br1414-431X0100-879Xopendoar:2010-07-02T00:00Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)false
dc.title.none.fl_str_mv Human papillomavirus detection and p16 methylation pattern in a case of esophageal papilloma
title Human papillomavirus detection and p16 methylation pattern in a case of esophageal papilloma
spellingShingle Human papillomavirus detection and p16 methylation pattern in a case of esophageal papilloma
Afonso,L.A.
Human papillomavirus
Esophageal cancer
Restriction fragment length polymorphism
title_short Human papillomavirus detection and p16 methylation pattern in a case of esophageal papilloma
title_full Human papillomavirus detection and p16 methylation pattern in a case of esophageal papilloma
title_fullStr Human papillomavirus detection and p16 methylation pattern in a case of esophageal papilloma
title_full_unstemmed Human papillomavirus detection and p16 methylation pattern in a case of esophageal papilloma
title_sort Human papillomavirus detection and p16 methylation pattern in a case of esophageal papilloma
author Afonso,L.A.
author_facet Afonso,L.A.
Moysés,N.
Cavalcanti,S.M.B.
author_role author
author2 Moysés,N.
Cavalcanti,S.M.B.
author2_role author
author
dc.contributor.author.fl_str_mv Afonso,L.A.
Moysés,N.
Cavalcanti,S.M.B.
dc.subject.por.fl_str_mv Human papillomavirus
Esophageal cancer
Restriction fragment length polymorphism
topic Human papillomavirus
Esophageal cancer
Restriction fragment length polymorphism
description Esophageal cancer is a prevalent cancer worldwide. Some studies have reported the possible etiology of human papillomavirus (HPV) in benign and malignant papillomas of the esophagus but the conclusions are controversial. In the present study, we investigated an esophageal papilloma from a 30-year-old male patient presenting aphasia. HPV DNA was detected by generic PCR using MY09/11 primers, and restriction fragment length polymorphism revealed the presence of HPV54, usually associated with benign genital lesions. Hypermethylation of the pINK4A gene was also investigated due to its relation to malignant transformation, but no modification was detected in the host gene. Except for an incipient reflux, no risk factors such as cigarette smoking, alcohol abuse or an infected sexual partner were recorded. Since esophageal lesions may have a malignant potential, HPV detection and typing are useful tools for patient follow-up.
publishDate 2010
dc.date.none.fl_str_mv 2010-07-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/report
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000700013
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dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0100-879X2010007500055
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
dc.source.none.fl_str_mv Brazilian Journal of Medical and Biological Research v.43 n.7 2010
reponame:Brazilian Journal of Medical and Biological Research
instname:Associação Brasileira de Divulgação Científica (ABDC)
instacron:ABDC
instname_str Associação Brasileira de Divulgação Científica (ABDC)
instacron_str ABDC
institution ABDC
reponame_str Brazilian Journal of Medical and Biological Research
collection Brazilian Journal of Medical and Biological Research
repository.name.fl_str_mv Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)
repository.mail.fl_str_mv bjournal@terra.com.br||bjournal@terra.com.br
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