Human papillomavirus detection and p16 methylation pattern in a case of esophageal papilloma
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , |
Tipo de documento: | Relatório |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Medical and Biological Research |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000700013 |
Resumo: | Esophageal cancer is a prevalent cancer worldwide. Some studies have reported the possible etiology of human papillomavirus (HPV) in benign and malignant papillomas of the esophagus but the conclusions are controversial. In the present study, we investigated an esophageal papilloma from a 30-year-old male patient presenting aphasia. HPV DNA was detected by generic PCR using MY09/11 primers, and restriction fragment length polymorphism revealed the presence of HPV54, usually associated with benign genital lesions. Hypermethylation of the pINK4A gene was also investigated due to its relation to malignant transformation, but no modification was detected in the host gene. Except for an incipient reflux, no risk factors such as cigarette smoking, alcohol abuse or an infected sexual partner were recorded. Since esophageal lesions may have a malignant potential, HPV detection and typing are useful tools for patient follow-up. |
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Human papillomavirus detection and p16 methylation pattern in a case of esophageal papillomaHuman papillomavirusEsophageal cancerRestriction fragment length polymorphismEsophageal cancer is a prevalent cancer worldwide. Some studies have reported the possible etiology of human papillomavirus (HPV) in benign and malignant papillomas of the esophagus but the conclusions are controversial. In the present study, we investigated an esophageal papilloma from a 30-year-old male patient presenting aphasia. HPV DNA was detected by generic PCR using MY09/11 primers, and restriction fragment length polymorphism revealed the presence of HPV54, usually associated with benign genital lesions. Hypermethylation of the pINK4A gene was also investigated due to its relation to malignant transformation, but no modification was detected in the host gene. Except for an incipient reflux, no risk factors such as cigarette smoking, alcohol abuse or an infected sexual partner were recorded. Since esophageal lesions may have a malignant potential, HPV detection and typing are useful tools for patient follow-up.Associação Brasileira de Divulgação Científica2010-07-01info:eu-repo/semantics/reportinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000700013Brazilian Journal of Medical and Biological Research v.43 n.7 2010reponame:Brazilian Journal of Medical and Biological Researchinstname:Associação Brasileira de Divulgação Científica (ABDC)instacron:ABDC10.1590/S0100-879X2010007500055info:eu-repo/semantics/openAccessAfonso,L.A.Moysés,N.Cavalcanti,S.M.B.eng2010-07-02T00:00:00Zoai:scielo:S0100-879X2010000700013Revistahttps://www.bjournal.org/https://old.scielo.br/oai/scielo-oai.phpbjournal@terra.com.br||bjournal@terra.com.br1414-431X0100-879Xopendoar:2010-07-02T00:00Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)false |
dc.title.none.fl_str_mv |
Human papillomavirus detection and p16 methylation pattern in a case of esophageal papilloma |
title |
Human papillomavirus detection and p16 methylation pattern in a case of esophageal papilloma |
spellingShingle |
Human papillomavirus detection and p16 methylation pattern in a case of esophageal papilloma Afonso,L.A. Human papillomavirus Esophageal cancer Restriction fragment length polymorphism |
title_short |
Human papillomavirus detection and p16 methylation pattern in a case of esophageal papilloma |
title_full |
Human papillomavirus detection and p16 methylation pattern in a case of esophageal papilloma |
title_fullStr |
Human papillomavirus detection and p16 methylation pattern in a case of esophageal papilloma |
title_full_unstemmed |
Human papillomavirus detection and p16 methylation pattern in a case of esophageal papilloma |
title_sort |
Human papillomavirus detection and p16 methylation pattern in a case of esophageal papilloma |
author |
Afonso,L.A. |
author_facet |
Afonso,L.A. Moysés,N. Cavalcanti,S.M.B. |
author_role |
author |
author2 |
Moysés,N. Cavalcanti,S.M.B. |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Afonso,L.A. Moysés,N. Cavalcanti,S.M.B. |
dc.subject.por.fl_str_mv |
Human papillomavirus Esophageal cancer Restriction fragment length polymorphism |
topic |
Human papillomavirus Esophageal cancer Restriction fragment length polymorphism |
description |
Esophageal cancer is a prevalent cancer worldwide. Some studies have reported the possible etiology of human papillomavirus (HPV) in benign and malignant papillomas of the esophagus but the conclusions are controversial. In the present study, we investigated an esophageal papilloma from a 30-year-old male patient presenting aphasia. HPV DNA was detected by generic PCR using MY09/11 primers, and restriction fragment length polymorphism revealed the presence of HPV54, usually associated with benign genital lesions. Hypermethylation of the pINK4A gene was also investigated due to its relation to malignant transformation, but no modification was detected in the host gene. Except for an incipient reflux, no risk factors such as cigarette smoking, alcohol abuse or an infected sexual partner were recorded. Since esophageal lesions may have a malignant potential, HPV detection and typing are useful tools for patient follow-up. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-07-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/report |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
report |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000700013 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000700013 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0100-879X2010007500055 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
dc.source.none.fl_str_mv |
Brazilian Journal of Medical and Biological Research v.43 n.7 2010 reponame:Brazilian Journal of Medical and Biological Research instname:Associação Brasileira de Divulgação Científica (ABDC) instacron:ABDC |
instname_str |
Associação Brasileira de Divulgação Científica (ABDC) |
instacron_str |
ABDC |
institution |
ABDC |
reponame_str |
Brazilian Journal of Medical and Biological Research |
collection |
Brazilian Journal of Medical and Biological Research |
repository.name.fl_str_mv |
Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC) |
repository.mail.fl_str_mv |
bjournal@terra.com.br||bjournal@terra.com.br |
_version_ |
1754302938928381952 |