STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg

Detalhes bibliográficos
Autor(a) principal: Giachini,F.R.
Data de Publicação: 2011
Outros Autores: Lima,V.V., Hannan,J.L., Carneiro,F.S., Webb,R.C., Tostes,R.C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Medical and Biological Research
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011001100002
Resumo: Highly efficient mechanisms regulate intracellular calcium (Ca2+) levels. The recent discovery of new components linking intracellular Ca2+ stores to plasma membrane Ca2+ entry channels has brought new insight into the understanding of Ca2+ homeostasis. Stromal interaction molecule 1 (STIM1) was identified as a Ca2+ sensor essential for Ca2+ store depletion-triggered Ca2+ influx. Orai1 was recognized as being an essential component for the Ca2+ release-activated Ca2+ (CRAC) channel. Together, these proteins participate in store-operated Ca2+ channel function. Defective regulation of intracellular Ca2+ is a hallmark of several diseases. In this review, we focus on Ca2+ regulation by the STIM1/Orai1 pathway and review evidence that implicates STIM1/Orai1 in several pathological conditions including cardiovascular and pulmonary diseases, among others.
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spelling STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the icebergCa2+ release-activated Ca2+ channelSarcoplasmic reticulumIntracellular Ca2+ storeCa2+ influxHighly efficient mechanisms regulate intracellular calcium (Ca2+) levels. The recent discovery of new components linking intracellular Ca2+ stores to plasma membrane Ca2+ entry channels has brought new insight into the understanding of Ca2+ homeostasis. Stromal interaction molecule 1 (STIM1) was identified as a Ca2+ sensor essential for Ca2+ store depletion-triggered Ca2+ influx. Orai1 was recognized as being an essential component for the Ca2+ release-activated Ca2+ (CRAC) channel. Together, these proteins participate in store-operated Ca2+ channel function. Defective regulation of intracellular Ca2+ is a hallmark of several diseases. In this review, we focus on Ca2+ regulation by the STIM1/Orai1 pathway and review evidence that implicates STIM1/Orai1 in several pathological conditions including cardiovascular and pulmonary diseases, among others.Associação Brasileira de Divulgação Científica2011-11-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011001100002Brazilian Journal of Medical and Biological Research v.44 n.11 2011reponame:Brazilian Journal of Medical and Biological Researchinstname:Associação Brasileira de Divulgação Científica (ABDC)instacron:ABDC10.1590/S0100-879X2011007500133info:eu-repo/semantics/openAccessGiachini,F.R.Lima,V.V.Hannan,J.L.Carneiro,F.S.Webb,R.C.Tostes,R.C.eng2011-11-01T00:00:00Zoai:scielo:S0100-879X2011001100002Revistahttps://www.bjournal.org/https://old.scielo.br/oai/scielo-oai.phpbjournal@terra.com.br||bjournal@terra.com.br1414-431X0100-879Xopendoar:2011-11-01T00:00Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)false
dc.title.none.fl_str_mv STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg
title STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg
spellingShingle STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg
Giachini,F.R.
Ca2+ release-activated Ca2+ channel
Sarcoplasmic reticulum
Intracellular Ca2+ store
Ca2+ influx
title_short STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg
title_full STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg
title_fullStr STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg
title_full_unstemmed STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg
title_sort STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg
author Giachini,F.R.
author_facet Giachini,F.R.
Lima,V.V.
Hannan,J.L.
Carneiro,F.S.
Webb,R.C.
Tostes,R.C.
author_role author
author2 Lima,V.V.
Hannan,J.L.
Carneiro,F.S.
Webb,R.C.
Tostes,R.C.
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Giachini,F.R.
Lima,V.V.
Hannan,J.L.
Carneiro,F.S.
Webb,R.C.
Tostes,R.C.
dc.subject.por.fl_str_mv Ca2+ release-activated Ca2+ channel
Sarcoplasmic reticulum
Intracellular Ca2+ store
Ca2+ influx
topic Ca2+ release-activated Ca2+ channel
Sarcoplasmic reticulum
Intracellular Ca2+ store
Ca2+ influx
description Highly efficient mechanisms regulate intracellular calcium (Ca2+) levels. The recent discovery of new components linking intracellular Ca2+ stores to plasma membrane Ca2+ entry channels has brought new insight into the understanding of Ca2+ homeostasis. Stromal interaction molecule 1 (STIM1) was identified as a Ca2+ sensor essential for Ca2+ store depletion-triggered Ca2+ influx. Orai1 was recognized as being an essential component for the Ca2+ release-activated Ca2+ (CRAC) channel. Together, these proteins participate in store-operated Ca2+ channel function. Defective regulation of intracellular Ca2+ is a hallmark of several diseases. In this review, we focus on Ca2+ regulation by the STIM1/Orai1 pathway and review evidence that implicates STIM1/Orai1 in several pathological conditions including cardiovascular and pulmonary diseases, among others.
publishDate 2011
dc.date.none.fl_str_mv 2011-11-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011001100002
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011001100002
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0100-879X2011007500133
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
dc.source.none.fl_str_mv Brazilian Journal of Medical and Biological Research v.44 n.11 2011
reponame:Brazilian Journal of Medical and Biological Research
instname:Associação Brasileira de Divulgação Científica (ABDC)
instacron:ABDC
instname_str Associação Brasileira de Divulgação Científica (ABDC)
instacron_str ABDC
institution ABDC
reponame_str Brazilian Journal of Medical and Biological Research
collection Brazilian Journal of Medical and Biological Research
repository.name.fl_str_mv Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)
repository.mail.fl_str_mv bjournal@terra.com.br||bjournal@terra.com.br
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