Focal adhesion kinase signaling in cardiac hypertrophy and failure

Detalhes bibliográficos
Autor(a) principal: Franchini,K.G.
Data de Publicação: 2009
Outros Autores: Clemente,C.F.M.Z., Marin,T.M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Medical and Biological Research
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000100008
Resumo: Focal adhesion kinase (FAK) is a broadly expressed tyrosine kinase implicated in cellular functions such as migration, growth and survival. Emerging data support a role for FAK in cardiac development, reactive hypertrophy and failure. Data reviewed here indicate that FAK plays a critical role at the cellular level in the responses of cardiomyocytes and cardiac fibroblasts to biomechanical stress and to hypertrophic agonists such as angiotensin II and endothelin. The signaling mechanisms regulated by FAK are discussed to provide insight into its role in the pathophysiology of cardiac hypertrophy and failure.
id ABDC-1_e7a9b24793d277f22bb3c80fe69325e2
oai_identifier_str oai:scielo:S0100-879X2009000100008
network_acronym_str ABDC-1
network_name_str Brazilian Journal of Medical and Biological Research
repository_id_str
spelling Focal adhesion kinase signaling in cardiac hypertrophy and failureFocal adhesion kinaseMechanical signalingCardiovascular systemSignal transductionFocal adhesion kinase (FAK) is a broadly expressed tyrosine kinase implicated in cellular functions such as migration, growth and survival. Emerging data support a role for FAK in cardiac development, reactive hypertrophy and failure. Data reviewed here indicate that FAK plays a critical role at the cellular level in the responses of cardiomyocytes and cardiac fibroblasts to biomechanical stress and to hypertrophic agonists such as angiotensin II and endothelin. The signaling mechanisms regulated by FAK are discussed to provide insight into its role in the pathophysiology of cardiac hypertrophy and failure.Associação Brasileira de Divulgação Científica2009-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000100008Brazilian Journal of Medical and Biological Research v.42 n.1 2009reponame:Brazilian Journal of Medical and Biological Researchinstname:Associação Brasileira de Divulgação Científica (ABDC)instacron:ABDC10.1590/S0100-879X2009000100008info:eu-repo/semantics/openAccessFranchini,K.G.Clemente,C.F.M.Z.Marin,T.M.eng2009-02-12T00:00:00Zoai:scielo:S0100-879X2009000100008Revistahttps://www.bjournal.org/https://old.scielo.br/oai/scielo-oai.phpbjournal@terra.com.br||bjournal@terra.com.br1414-431X0100-879Xopendoar:2009-02-12T00:00Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)false
dc.title.none.fl_str_mv Focal adhesion kinase signaling in cardiac hypertrophy and failure
title Focal adhesion kinase signaling in cardiac hypertrophy and failure
spellingShingle Focal adhesion kinase signaling in cardiac hypertrophy and failure
Franchini,K.G.
Focal adhesion kinase
Mechanical signaling
Cardiovascular system
Signal transduction
title_short Focal adhesion kinase signaling in cardiac hypertrophy and failure
title_full Focal adhesion kinase signaling in cardiac hypertrophy and failure
title_fullStr Focal adhesion kinase signaling in cardiac hypertrophy and failure
title_full_unstemmed Focal adhesion kinase signaling in cardiac hypertrophy and failure
title_sort Focal adhesion kinase signaling in cardiac hypertrophy and failure
author Franchini,K.G.
author_facet Franchini,K.G.
Clemente,C.F.M.Z.
Marin,T.M.
author_role author
author2 Clemente,C.F.M.Z.
Marin,T.M.
author2_role author
author
dc.contributor.author.fl_str_mv Franchini,K.G.
Clemente,C.F.M.Z.
Marin,T.M.
dc.subject.por.fl_str_mv Focal adhesion kinase
Mechanical signaling
Cardiovascular system
Signal transduction
topic Focal adhesion kinase
Mechanical signaling
Cardiovascular system
Signal transduction
description Focal adhesion kinase (FAK) is a broadly expressed tyrosine kinase implicated in cellular functions such as migration, growth and survival. Emerging data support a role for FAK in cardiac development, reactive hypertrophy and failure. Data reviewed here indicate that FAK plays a critical role at the cellular level in the responses of cardiomyocytes and cardiac fibroblasts to biomechanical stress and to hypertrophic agonists such as angiotensin II and endothelin. The signaling mechanisms regulated by FAK are discussed to provide insight into its role in the pathophysiology of cardiac hypertrophy and failure.
publishDate 2009
dc.date.none.fl_str_mv 2009-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000100008
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000100008
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0100-879X2009000100008
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
dc.source.none.fl_str_mv Brazilian Journal of Medical and Biological Research v.42 n.1 2009
reponame:Brazilian Journal of Medical and Biological Research
instname:Associação Brasileira de Divulgação Científica (ABDC)
instacron:ABDC
instname_str Associação Brasileira de Divulgação Científica (ABDC)
instacron_str ABDC
institution ABDC
reponame_str Brazilian Journal of Medical and Biological Research
collection Brazilian Journal of Medical and Biological Research
repository.name.fl_str_mv Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)
repository.mail.fl_str_mv bjournal@terra.com.br||bjournal@terra.com.br
_version_ 1754302937167822848

Registros relacionados