Influence of intrauterine and extrauterine growth on neurodevelopmental outcome of monozygotic twins

Detalhes bibliográficos
Autor(a) principal: Reolon,R.K.
Data de Publicação: 2008
Outros Autores: Rotta,N.T., Agranonik,M., Silva,A.A. Moura da, Goldani,M.Z.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Medical and Biological Research
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000800010
Resumo: There have been indications that intrauterine and early extrauterine growth can influence childhood mental and motor function. The objective of the present study was to evaluate the influence of intrauterine growth restriction and early extrauterine head growth on the neurodevelopmental outcome of monozygotic twins. Thirty-six monozygous twin pairs were evaluated at the corrected age of 12 to 42 months. Intrauterine growth restriction was quantified using the fetal growth ratio. The effects of birth weight ratio, head circumference at birth and current head circumference on mental and motor outcomes were estimated using mixed-effect linear regression models. Separate estimates of the between (interpair) and within (intrapair) effects of each measure on development were thus obtained. Neurodevelopment was assessed with the Bayley Scales of Infant Development, 2nd edition, by a psychologist blind to the exposure. A standardized neurological examination was performed by a neuropediatrician who was unaware of the exposures under investigation. After adjustment, birth weight ratio and head circumference at birth were not associated with motor or mental outcomes. Current head circumference was associated with mental but not with motor outcomes. Only the intrapair twin effect was significant. An increase of 1 cm in current head circumference of one twin compared with the other was associated with 3.2 points higher in Mental Developmental Index (95%CI = 1.06-5.32; P < 0.03). Thus, no effect of intrauterine growth was found on cognition and only postnatal head growth was associated with cognition. This effect was not shared by the co-twin.
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spelling Influence of intrauterine and extrauterine growth on neurodevelopmental outcome of monozygotic twinsIntrauterine growth restrictionNeurodevelopmentMonozygotic twinsFetal growth ratioHead circumferenceNeurocognitive developmentThere have been indications that intrauterine and early extrauterine growth can influence childhood mental and motor function. The objective of the present study was to evaluate the influence of intrauterine growth restriction and early extrauterine head growth on the neurodevelopmental outcome of monozygotic twins. Thirty-six monozygous twin pairs were evaluated at the corrected age of 12 to 42 months. Intrauterine growth restriction was quantified using the fetal growth ratio. The effects of birth weight ratio, head circumference at birth and current head circumference on mental and motor outcomes were estimated using mixed-effect linear regression models. Separate estimates of the between (interpair) and within (intrapair) effects of each measure on development were thus obtained. Neurodevelopment was assessed with the Bayley Scales of Infant Development, 2nd edition, by a psychologist blind to the exposure. A standardized neurological examination was performed by a neuropediatrician who was unaware of the exposures under investigation. After adjustment, birth weight ratio and head circumference at birth were not associated with motor or mental outcomes. Current head circumference was associated with mental but not with motor outcomes. Only the intrapair twin effect was significant. An increase of 1 cm in current head circumference of one twin compared with the other was associated with 3.2 points higher in Mental Developmental Index (95%CI = 1.06-5.32; P < 0.03). Thus, no effect of intrauterine growth was found on cognition and only postnatal head growth was associated with cognition. This effect was not shared by the co-twin.Associação Brasileira de Divulgação Científica2008-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000800010Brazilian Journal of Medical and Biological Research v.41 n.8 2008reponame:Brazilian Journal of Medical and Biological Researchinstname:Associação Brasileira de Divulgação Científica (ABDC)instacron:ABDC10.1590/S0100-879X2008005000032info:eu-repo/semantics/openAccessReolon,R.K.Rotta,N.T.Agranonik,M.Silva,A.A. Moura daGoldani,M.Z.eng2008-10-13T00:00:00Zoai:scielo:S0100-879X2008000800010Revistahttps://www.bjournal.org/https://old.scielo.br/oai/scielo-oai.phpbjournal@terra.com.br||bjournal@terra.com.br1414-431X0100-879Xopendoar:2008-10-13T00:00Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)false
dc.title.none.fl_str_mv Influence of intrauterine and extrauterine growth on neurodevelopmental outcome of monozygotic twins
title Influence of intrauterine and extrauterine growth on neurodevelopmental outcome of monozygotic twins
spellingShingle Influence of intrauterine and extrauterine growth on neurodevelopmental outcome of monozygotic twins
Reolon,R.K.
Intrauterine growth restriction
Neurodevelopment
Monozygotic twins
Fetal growth ratio
Head circumference
Neurocognitive development
title_short Influence of intrauterine and extrauterine growth on neurodevelopmental outcome of monozygotic twins
title_full Influence of intrauterine and extrauterine growth on neurodevelopmental outcome of monozygotic twins
title_fullStr Influence of intrauterine and extrauterine growth on neurodevelopmental outcome of monozygotic twins
title_full_unstemmed Influence of intrauterine and extrauterine growth on neurodevelopmental outcome of monozygotic twins
title_sort Influence of intrauterine and extrauterine growth on neurodevelopmental outcome of monozygotic twins
author Reolon,R.K.
author_facet Reolon,R.K.
Rotta,N.T.
Agranonik,M.
Silva,A.A. Moura da
Goldani,M.Z.
author_role author
author2 Rotta,N.T.
Agranonik,M.
Silva,A.A. Moura da
Goldani,M.Z.
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Reolon,R.K.
Rotta,N.T.
Agranonik,M.
Silva,A.A. Moura da
Goldani,M.Z.
dc.subject.por.fl_str_mv Intrauterine growth restriction
Neurodevelopment
Monozygotic twins
Fetal growth ratio
Head circumference
Neurocognitive development
topic Intrauterine growth restriction
Neurodevelopment
Monozygotic twins
Fetal growth ratio
Head circumference
Neurocognitive development
description There have been indications that intrauterine and early extrauterine growth can influence childhood mental and motor function. The objective of the present study was to evaluate the influence of intrauterine growth restriction and early extrauterine head growth on the neurodevelopmental outcome of monozygotic twins. Thirty-six monozygous twin pairs were evaluated at the corrected age of 12 to 42 months. Intrauterine growth restriction was quantified using the fetal growth ratio. The effects of birth weight ratio, head circumference at birth and current head circumference on mental and motor outcomes were estimated using mixed-effect linear regression models. Separate estimates of the between (interpair) and within (intrapair) effects of each measure on development were thus obtained. Neurodevelopment was assessed with the Bayley Scales of Infant Development, 2nd edition, by a psychologist blind to the exposure. A standardized neurological examination was performed by a neuropediatrician who was unaware of the exposures under investigation. After adjustment, birth weight ratio and head circumference at birth were not associated with motor or mental outcomes. Current head circumference was associated with mental but not with motor outcomes. Only the intrapair twin effect was significant. An increase of 1 cm in current head circumference of one twin compared with the other was associated with 3.2 points higher in Mental Developmental Index (95%CI = 1.06-5.32; P < 0.03). Thus, no effect of intrauterine growth was found on cognition and only postnatal head growth was associated with cognition. This effect was not shared by the co-twin.
publishDate 2008
dc.date.none.fl_str_mv 2008-08-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000800010
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000800010
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0100-879X2008005000032
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
dc.source.none.fl_str_mv Brazilian Journal of Medical and Biological Research v.41 n.8 2008
reponame:Brazilian Journal of Medical and Biological Research
instname:Associação Brasileira de Divulgação Científica (ABDC)
instacron:ABDC
instname_str Associação Brasileira de Divulgação Científica (ABDC)
instacron_str ABDC
institution ABDC
reponame_str Brazilian Journal of Medical and Biological Research
collection Brazilian Journal of Medical and Biological Research
repository.name.fl_str_mv Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)
repository.mail.fl_str_mv bjournal@terra.com.br||bjournal@terra.com.br
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