Alternative mitochondrial functions in cell physiopathology: beyond ATP production

Detalhes bibliográficos
Autor(a) principal: Kowaltowski,A.J.
Data de Publicação: 2000
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Medical and Biological Research
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000200014
Resumo: It is well known that mitochondria are the main site for ATP generation within most tissues. However, mitochondria also participate in a surprising number of alternative activities, including intracellular Ca2+ regulation, thermogenesis and the control of apoptosis. In addition, mitochondria are the main cellular generators of reactive oxygen species, and may trigger necrotic cell death under conditions of oxidative stress. This review concentrates on these alternative mitochondrial functions, and their role in cell physiopathology.
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spelling Alternative mitochondrial functions in cell physiopathology: beyond ATP productionmitochondrial permeability transitionuncoupling proteinsalternative oxidasecardioprotectionfree radicalsagingIt is well known that mitochondria are the main site for ATP generation within most tissues. However, mitochondria also participate in a surprising number of alternative activities, including intracellular Ca2+ regulation, thermogenesis and the control of apoptosis. In addition, mitochondria are the main cellular generators of reactive oxygen species, and may trigger necrotic cell death under conditions of oxidative stress. This review concentrates on these alternative mitochondrial functions, and their role in cell physiopathology.Associação Brasileira de Divulgação Científica2000-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000200014Brazilian Journal of Medical and Biological Research v.33 n.2 2000reponame:Brazilian Journal of Medical and Biological Researchinstname:Associação Brasileira de Divulgação Científica (ABDC)instacron:ABDC10.1590/S0100-879X2000000200014info:eu-repo/semantics/openAccessKowaltowski,A.J.eng2000-02-02T00:00:00Zoai:scielo:S0100-879X2000000200014Revistahttps://www.bjournal.org/https://old.scielo.br/oai/scielo-oai.phpbjournal@terra.com.br||bjournal@terra.com.br1414-431X0100-879Xopendoar:2000-02-02T00:00Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)false
dc.title.none.fl_str_mv Alternative mitochondrial functions in cell physiopathology: beyond ATP production
title Alternative mitochondrial functions in cell physiopathology: beyond ATP production
spellingShingle Alternative mitochondrial functions in cell physiopathology: beyond ATP production
Kowaltowski,A.J.
mitochondrial permeability transition
uncoupling proteins
alternative oxidase
cardioprotection
free radicals
aging
title_short Alternative mitochondrial functions in cell physiopathology: beyond ATP production
title_full Alternative mitochondrial functions in cell physiopathology: beyond ATP production
title_fullStr Alternative mitochondrial functions in cell physiopathology: beyond ATP production
title_full_unstemmed Alternative mitochondrial functions in cell physiopathology: beyond ATP production
title_sort Alternative mitochondrial functions in cell physiopathology: beyond ATP production
author Kowaltowski,A.J.
author_facet Kowaltowski,A.J.
author_role author
dc.contributor.author.fl_str_mv Kowaltowski,A.J.
dc.subject.por.fl_str_mv mitochondrial permeability transition
uncoupling proteins
alternative oxidase
cardioprotection
free radicals
aging
topic mitochondrial permeability transition
uncoupling proteins
alternative oxidase
cardioprotection
free radicals
aging
description It is well known that mitochondria are the main site for ATP generation within most tissues. However, mitochondria also participate in a surprising number of alternative activities, including intracellular Ca2+ regulation, thermogenesis and the control of apoptosis. In addition, mitochondria are the main cellular generators of reactive oxygen species, and may trigger necrotic cell death under conditions of oxidative stress. This review concentrates on these alternative mitochondrial functions, and their role in cell physiopathology.
publishDate 2000
dc.date.none.fl_str_mv 2000-02-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000200014
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000200014
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0100-879X2000000200014
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
dc.source.none.fl_str_mv Brazilian Journal of Medical and Biological Research v.33 n.2 2000
reponame:Brazilian Journal of Medical and Biological Research
instname:Associação Brasileira de Divulgação Científica (ABDC)
instacron:ABDC
instname_str Associação Brasileira de Divulgação Científica (ABDC)
instacron_str ABDC
institution ABDC
reponame_str Brazilian Journal of Medical and Biological Research
collection Brazilian Journal of Medical and Biological Research
repository.name.fl_str_mv Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)
repository.mail.fl_str_mv bjournal@terra.com.br||bjournal@terra.com.br
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