Diagnostic validity of biomarkers in Parkinson’s Disease: systematic review and meta-analysis

Detalhes bibliográficos
Autor(a) principal: Costa,Maria Fernanda Baeta Neves Alonso da
Data de Publicação: 2018
Outros Autores: Reisdorfer,Emilene, Kempfer,Silvana Silveira, Fernandes,Gisele Cristina Manfrini, Porporatti,André Luís, Canto,Graziela De Luca
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista Brasileira de Enfermagem (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0034-71672018000603074
Resumo: ABSTRACT Objective: To identify biomarkers for Parkinson’s disease, cerebrospinal fluid, blood, saliva, and urine. Method: The studies were collected from the Cochrane, LILACS, PubMed, SCOPUS, WEB OF SCIENCE, OpenGrey, ProQuest and Google Scholar databases starting from May 3, 2016 and updated on March 20, 2017. Twenty-two studies were evaluated, by the Quality Assessment Tool for Diagnostic Accuracy Studies and Review Manager 5.3. Results: Evidence shows that serum antibodies can be used as highly specific and accurate biomarkers for the diagnosis of Parkinson’s disease at the outset. Biomarkers in the cerebrospinal fluid are related to increased motor severity, postural instability, gait abnormality, and cognitive impairment. Conclusion: Serum and cerebrospinal antibodies can be used as diagnostic biomarkers at the onset of the disease.
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spelling Diagnostic validity of biomarkers in Parkinson’s Disease: systematic review and meta-analysisReviewParkinson’s DiseaseDiagnosticBiomarkersBloodABSTRACT Objective: To identify biomarkers for Parkinson’s disease, cerebrospinal fluid, blood, saliva, and urine. Method: The studies were collected from the Cochrane, LILACS, PubMed, SCOPUS, WEB OF SCIENCE, OpenGrey, ProQuest and Google Scholar databases starting from May 3, 2016 and updated on March 20, 2017. Twenty-two studies were evaluated, by the Quality Assessment Tool for Diagnostic Accuracy Studies and Review Manager 5.3. Results: Evidence shows that serum antibodies can be used as highly specific and accurate biomarkers for the diagnosis of Parkinson’s disease at the outset. Biomarkers in the cerebrospinal fluid are related to increased motor severity, postural instability, gait abnormality, and cognitive impairment. Conclusion: Serum and cerebrospinal antibodies can be used as diagnostic biomarkers at the onset of the disease.Associação Brasileira de Enfermagem2018-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0034-71672018000603074Revista Brasileira de Enfermagem v.71 n.6 2018reponame:Revista Brasileira de Enfermagem (Online)instname:Associação Brasileira de Enfermagem (ABEN)instacron:ABEN10.1590/0034-7167-2017-0822info:eu-repo/semantics/openAccessCosta,Maria Fernanda Baeta Neves Alonso daReisdorfer,EmileneKempfer,Silvana SilveiraFernandes,Gisele Cristina ManfriniPorporatti,André LuísCanto,Graziela De Lucaeng2018-12-10T00:00:00Zoai:scielo:S0034-71672018000603074Revistahttp://www.scielo.br/rebenhttps://old.scielo.br/oai/scielo-oai.phpreben@abennacional.org.br||telma.garcia@abennacional.org.br|| editorreben@abennacional.org.br1984-04460034-7167opendoar:2018-12-10T00:00Revista Brasileira de Enfermagem (Online) - Associação Brasileira de Enfermagem (ABEN)false
dc.title.none.fl_str_mv Diagnostic validity of biomarkers in Parkinson’s Disease: systematic review and meta-analysis
title Diagnostic validity of biomarkers in Parkinson’s Disease: systematic review and meta-analysis
spellingShingle Diagnostic validity of biomarkers in Parkinson’s Disease: systematic review and meta-analysis
Costa,Maria Fernanda Baeta Neves Alonso da
Review
Parkinson’s Disease
Diagnostic
Biomarkers
Blood
title_short Diagnostic validity of biomarkers in Parkinson’s Disease: systematic review and meta-analysis
title_full Diagnostic validity of biomarkers in Parkinson’s Disease: systematic review and meta-analysis
title_fullStr Diagnostic validity of biomarkers in Parkinson’s Disease: systematic review and meta-analysis
title_full_unstemmed Diagnostic validity of biomarkers in Parkinson’s Disease: systematic review and meta-analysis
title_sort Diagnostic validity of biomarkers in Parkinson’s Disease: systematic review and meta-analysis
author Costa,Maria Fernanda Baeta Neves Alonso da
author_facet Costa,Maria Fernanda Baeta Neves Alonso da
Reisdorfer,Emilene
Kempfer,Silvana Silveira
Fernandes,Gisele Cristina Manfrini
Porporatti,André Luís
Canto,Graziela De Luca
author_role author
author2 Reisdorfer,Emilene
Kempfer,Silvana Silveira
Fernandes,Gisele Cristina Manfrini
Porporatti,André Luís
Canto,Graziela De Luca
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Costa,Maria Fernanda Baeta Neves Alonso da
Reisdorfer,Emilene
Kempfer,Silvana Silveira
Fernandes,Gisele Cristina Manfrini
Porporatti,André Luís
Canto,Graziela De Luca
dc.subject.por.fl_str_mv Review
Parkinson’s Disease
Diagnostic
Biomarkers
Blood
topic Review
Parkinson’s Disease
Diagnostic
Biomarkers
Blood
description ABSTRACT Objective: To identify biomarkers for Parkinson’s disease, cerebrospinal fluid, blood, saliva, and urine. Method: The studies were collected from the Cochrane, LILACS, PubMed, SCOPUS, WEB OF SCIENCE, OpenGrey, ProQuest and Google Scholar databases starting from May 3, 2016 and updated on March 20, 2017. Twenty-two studies were evaluated, by the Quality Assessment Tool for Diagnostic Accuracy Studies and Review Manager 5.3. Results: Evidence shows that serum antibodies can be used as highly specific and accurate biomarkers for the diagnosis of Parkinson’s disease at the outset. Biomarkers in the cerebrospinal fluid are related to increased motor severity, postural instability, gait abnormality, and cognitive impairment. Conclusion: Serum and cerebrospinal antibodies can be used as diagnostic biomarkers at the onset of the disease.
publishDate 2018
dc.date.none.fl_str_mv 2018-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0034-71672018000603074
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0034-71672018000603074
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0034-7167-2017-0822
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Associação Brasileira de Enfermagem
publisher.none.fl_str_mv Associação Brasileira de Enfermagem
dc.source.none.fl_str_mv Revista Brasileira de Enfermagem v.71 n.6 2018
reponame:Revista Brasileira de Enfermagem (Online)
instname:Associação Brasileira de Enfermagem (ABEN)
instacron:ABEN
instname_str Associação Brasileira de Enfermagem (ABEN)
instacron_str ABEN
institution ABEN
reponame_str Revista Brasileira de Enfermagem (Online)
collection Revista Brasileira de Enfermagem (Online)
repository.name.fl_str_mv Revista Brasileira de Enfermagem (Online) - Associação Brasileira de Enfermagem (ABEN)
repository.mail.fl_str_mv reben@abennacional.org.br||telma.garcia@abennacional.org.br|| editorreben@abennacional.org.br
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