Effect of process variables on the preparation of artificial bone cements
Autor(a) principal: | |
---|---|
Data de Publicação: | 2013 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Chemical Engineering |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-66322013000400018 |
Resumo: | The present work concerns the preparation of bone cements based on poly(methyl methacrylate) (PMMA), used mainly for prosthesis fixation and cavity filling for correction of human bone failures. A typical bone cement recipe contains methyl methacrylate, which polymerizes in situ during cement application. An inherent problem of this reaction is the large amount of heat released during the cement preparation, which may lead to irreparable damage of living tissues. Optimization of PMMA-based bone cement recipes is thus an important step towards safe and reliable clinical usage of these materials. Important process variables related to the reaction temperature profile and the mixing of the recipe constituents were studied in order to allow for the adequate production of bone cements. It is shown that the average molar mass and size of the PMMA particles used in the production of the bone cement, as well as incorporation of radiopaque contrast, co-monomers and fillers into the bone recipe play fundamental roles in the course of the polymerization reaction. Furthermore, the injection vessel geometry may interfere dramatically with the temperature profile and the time for its occurrence. Finally, it has been observed that the morphology of the PMMA particles strongly affects the mixing of the bone cement components. |
id |
ABEQ-1_210deffa34bbac5066db233e2f5d0ae5 |
---|---|
oai_identifier_str |
oai:scielo:S0104-66322013000400018 |
network_acronym_str |
ABEQ-1 |
network_name_str |
Brazilian Journal of Chemical Engineering |
repository_id_str |
|
spelling |
Effect of process variables on the preparation of artificial bone cementsBiomaterialsBone cementMixingPMMASuspension polymerizationThe present work concerns the preparation of bone cements based on poly(methyl methacrylate) (PMMA), used mainly for prosthesis fixation and cavity filling for correction of human bone failures. A typical bone cement recipe contains methyl methacrylate, which polymerizes in situ during cement application. An inherent problem of this reaction is the large amount of heat released during the cement preparation, which may lead to irreparable damage of living tissues. Optimization of PMMA-based bone cement recipes is thus an important step towards safe and reliable clinical usage of these materials. Important process variables related to the reaction temperature profile and the mixing of the recipe constituents were studied in order to allow for the adequate production of bone cements. It is shown that the average molar mass and size of the PMMA particles used in the production of the bone cement, as well as incorporation of radiopaque contrast, co-monomers and fillers into the bone recipe play fundamental roles in the course of the polymerization reaction. Furthermore, the injection vessel geometry may interfere dramatically with the temperature profile and the time for its occurrence. Finally, it has been observed that the morphology of the PMMA particles strongly affects the mixing of the bone cement components.Brazilian Society of Chemical Engineering2013-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-66322013000400018Brazilian Journal of Chemical Engineering v.30 n.4 2013reponame:Brazilian Journal of Chemical Engineeringinstname:Associação Brasileira de Engenharia Química (ABEQ)instacron:ABEQ10.1590/S0104-66322013000400018info:eu-repo/semantics/openAccessSantos Jr.,J. G. F.Pita,V. J. R. R.Melo,P. A.Nele,M.Pinto,J. C.eng2014-01-10T00:00:00Zoai:scielo:S0104-66322013000400018Revistahttps://www.scielo.br/j/bjce/https://old.scielo.br/oai/scielo-oai.phprgiudici@usp.br||rgiudici@usp.br1678-43830104-6632opendoar:2014-01-10T00:00Brazilian Journal of Chemical Engineering - Associação Brasileira de Engenharia Química (ABEQ)false |
dc.title.none.fl_str_mv |
Effect of process variables on the preparation of artificial bone cements |
title |
Effect of process variables on the preparation of artificial bone cements |
spellingShingle |
Effect of process variables on the preparation of artificial bone cements Santos Jr.,J. G. F. Biomaterials Bone cement Mixing PMMA Suspension polymerization |
title_short |
Effect of process variables on the preparation of artificial bone cements |
title_full |
Effect of process variables on the preparation of artificial bone cements |
title_fullStr |
Effect of process variables on the preparation of artificial bone cements |
title_full_unstemmed |
Effect of process variables on the preparation of artificial bone cements |
title_sort |
Effect of process variables on the preparation of artificial bone cements |
author |
Santos Jr.,J. G. F. |
author_facet |
Santos Jr.,J. G. F. Pita,V. J. R. R. Melo,P. A. Nele,M. Pinto,J. C. |
author_role |
author |
author2 |
Pita,V. J. R. R. Melo,P. A. Nele,M. Pinto,J. C. |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Santos Jr.,J. G. F. Pita,V. J. R. R. Melo,P. A. Nele,M. Pinto,J. C. |
dc.subject.por.fl_str_mv |
Biomaterials Bone cement Mixing PMMA Suspension polymerization |
topic |
Biomaterials Bone cement Mixing PMMA Suspension polymerization |
description |
The present work concerns the preparation of bone cements based on poly(methyl methacrylate) (PMMA), used mainly for prosthesis fixation and cavity filling for correction of human bone failures. A typical bone cement recipe contains methyl methacrylate, which polymerizes in situ during cement application. An inherent problem of this reaction is the large amount of heat released during the cement preparation, which may lead to irreparable damage of living tissues. Optimization of PMMA-based bone cement recipes is thus an important step towards safe and reliable clinical usage of these materials. Important process variables related to the reaction temperature profile and the mixing of the recipe constituents were studied in order to allow for the adequate production of bone cements. It is shown that the average molar mass and size of the PMMA particles used in the production of the bone cement, as well as incorporation of radiopaque contrast, co-monomers and fillers into the bone recipe play fundamental roles in the course of the polymerization reaction. Furthermore, the injection vessel geometry may interfere dramatically with the temperature profile and the time for its occurrence. Finally, it has been observed that the morphology of the PMMA particles strongly affects the mixing of the bone cement components. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-66322013000400018 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-66322013000400018 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0104-66322013000400018 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Brazilian Society of Chemical Engineering |
publisher.none.fl_str_mv |
Brazilian Society of Chemical Engineering |
dc.source.none.fl_str_mv |
Brazilian Journal of Chemical Engineering v.30 n.4 2013 reponame:Brazilian Journal of Chemical Engineering instname:Associação Brasileira de Engenharia Química (ABEQ) instacron:ABEQ |
instname_str |
Associação Brasileira de Engenharia Química (ABEQ) |
instacron_str |
ABEQ |
institution |
ABEQ |
reponame_str |
Brazilian Journal of Chemical Engineering |
collection |
Brazilian Journal of Chemical Engineering |
repository.name.fl_str_mv |
Brazilian Journal of Chemical Engineering - Associação Brasileira de Engenharia Química (ABEQ) |
repository.mail.fl_str_mv |
rgiudici@usp.br||rgiudici@usp.br |
_version_ |
1754213174234578944 |