THE EFFECT OF THE ADDITION OF INVERT SUGAR ON THE PRODUCTION OF CEPHALOSPORIN C IN A FED-BATCH BIOREACTOR
Autor(a) principal: | |
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Data de Publicação: | 1998 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Chemical Engineering |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-66321998000400001 |
Resumo: | Cephalosporin C, a b -lactam antibiotic, is the starting molecule for industrial production of semi-synthetic cephalosporins. The bioprocess for its production is carried out in batch stirred and aerated tank reactors utilizing strains of the filamentous fungus Cephalosporium acremonium. In this work a comparison was made between the processes of production of cephalosporin C in a conventional batch bioreactor, with synthetic medium containing glucose and sucrose, and in a fed-batch reactor at several flowrates of supplementary medium containing invert sucrose. In general, the fed-batch process was shown to be more efficient than the conventional batch one, and the process in which the lowest supplementation flowrate was used presented an antibiotic production significantly higher than those obtained under the other conditions. |
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Brazilian Journal of Chemical Engineering |
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THE EFFECT OF THE ADDITION OF INVERT SUGAR ON THE PRODUCTION OF CEPHALOSPORIN C IN A FED-BATCH BIOREACTORCephalosporium acremoniuminvert sugarcephalosporin Cfed batchCephalosporin C, a b -lactam antibiotic, is the starting molecule for industrial production of semi-synthetic cephalosporins. The bioprocess for its production is carried out in batch stirred and aerated tank reactors utilizing strains of the filamentous fungus Cephalosporium acremonium. In this work a comparison was made between the processes of production of cephalosporin C in a conventional batch bioreactor, with synthetic medium containing glucose and sucrose, and in a fed-batch reactor at several flowrates of supplementary medium containing invert sucrose. In general, the fed-batch process was shown to be more efficient than the conventional batch one, and the process in which the lowest supplementation flowrate was used presented an antibiotic production significantly higher than those obtained under the other conditions.Brazilian Society of Chemical Engineering1998-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-66321998000400001Brazilian Journal of Chemical Engineering v.15 n.4 1998reponame:Brazilian Journal of Chemical Engineeringinstname:Associação Brasileira de Engenharia Química (ABEQ)instacron:ABEQ10.1590/S0104-66321998000400001info:eu-repo/semantics/openAccessSilva,A.S.Cruz,A.J.G.Araujo,M.L.G.C.Hokka,C.O.eng1998-12-07T00:00:00Zoai:scielo:S0104-66321998000400001Revistahttps://www.scielo.br/j/bjce/https://old.scielo.br/oai/scielo-oai.phprgiudici@usp.br||rgiudici@usp.br1678-43830104-6632opendoar:1998-12-07T00:00Brazilian Journal of Chemical Engineering - Associação Brasileira de Engenharia Química (ABEQ)false |
dc.title.none.fl_str_mv |
THE EFFECT OF THE ADDITION OF INVERT SUGAR ON THE PRODUCTION OF CEPHALOSPORIN C IN A FED-BATCH BIOREACTOR |
title |
THE EFFECT OF THE ADDITION OF INVERT SUGAR ON THE PRODUCTION OF CEPHALOSPORIN C IN A FED-BATCH BIOREACTOR |
spellingShingle |
THE EFFECT OF THE ADDITION OF INVERT SUGAR ON THE PRODUCTION OF CEPHALOSPORIN C IN A FED-BATCH BIOREACTOR Silva,A.S. Cephalosporium acremonium invert sugar cephalosporin C fed batch |
title_short |
THE EFFECT OF THE ADDITION OF INVERT SUGAR ON THE PRODUCTION OF CEPHALOSPORIN C IN A FED-BATCH BIOREACTOR |
title_full |
THE EFFECT OF THE ADDITION OF INVERT SUGAR ON THE PRODUCTION OF CEPHALOSPORIN C IN A FED-BATCH BIOREACTOR |
title_fullStr |
THE EFFECT OF THE ADDITION OF INVERT SUGAR ON THE PRODUCTION OF CEPHALOSPORIN C IN A FED-BATCH BIOREACTOR |
title_full_unstemmed |
THE EFFECT OF THE ADDITION OF INVERT SUGAR ON THE PRODUCTION OF CEPHALOSPORIN C IN A FED-BATCH BIOREACTOR |
title_sort |
THE EFFECT OF THE ADDITION OF INVERT SUGAR ON THE PRODUCTION OF CEPHALOSPORIN C IN A FED-BATCH BIOREACTOR |
author |
Silva,A.S. |
author_facet |
Silva,A.S. Cruz,A.J.G. Araujo,M.L.G.C. Hokka,C.O. |
author_role |
author |
author2 |
Cruz,A.J.G. Araujo,M.L.G.C. Hokka,C.O. |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Silva,A.S. Cruz,A.J.G. Araujo,M.L.G.C. Hokka,C.O. |
dc.subject.por.fl_str_mv |
Cephalosporium acremonium invert sugar cephalosporin C fed batch |
topic |
Cephalosporium acremonium invert sugar cephalosporin C fed batch |
description |
Cephalosporin C, a b -lactam antibiotic, is the starting molecule for industrial production of semi-synthetic cephalosporins. The bioprocess for its production is carried out in batch stirred and aerated tank reactors utilizing strains of the filamentous fungus Cephalosporium acremonium. In this work a comparison was made between the processes of production of cephalosporin C in a conventional batch bioreactor, with synthetic medium containing glucose and sucrose, and in a fed-batch reactor at several flowrates of supplementary medium containing invert sucrose. In general, the fed-batch process was shown to be more efficient than the conventional batch one, and the process in which the lowest supplementation flowrate was used presented an antibiotic production significantly higher than those obtained under the other conditions. |
publishDate |
1998 |
dc.date.none.fl_str_mv |
1998-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-66321998000400001 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-66321998000400001 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0104-66321998000400001 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Brazilian Society of Chemical Engineering |
publisher.none.fl_str_mv |
Brazilian Society of Chemical Engineering |
dc.source.none.fl_str_mv |
Brazilian Journal of Chemical Engineering v.15 n.4 1998 reponame:Brazilian Journal of Chemical Engineering instname:Associação Brasileira de Engenharia Química (ABEQ) instacron:ABEQ |
instname_str |
Associação Brasileira de Engenharia Química (ABEQ) |
instacron_str |
ABEQ |
institution |
ABEQ |
reponame_str |
Brazilian Journal of Chemical Engineering |
collection |
Brazilian Journal of Chemical Engineering |
repository.name.fl_str_mv |
Brazilian Journal of Chemical Engineering - Associação Brasileira de Engenharia Química (ABEQ) |
repository.mail.fl_str_mv |
rgiudici@usp.br||rgiudici@usp.br |
_version_ |
1754213170367430656 |