Surface morphology of spray-dried nanoparticle-coated microparticles designed as an oral drug delivery system

Detalhes bibliográficos
Autor(a) principal: Beck,R. C. R.
Data de Publicação: 2008
Outros Autores: Lionzo,M. I. Z., Costa,T. M. H., Benvenutti,E. V., Ré,M. I., Gallas,M. R., Pohlmann,A. R., Guterres,S. S.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Chemical Engineering
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-66322008000200016
Resumo: This paper was devoted to studying the influence of coating material (nanocapsules or nanospheres), drug model (diclofenac, acid or salt) and method of preparation on the morphological characteristics of nanoparticle-coated microparticles. The cores of microparticles were obtained by spray drying or evaporation and the coating was applied by spray drying. SEM analyses showed nanostructures coating the surface of nanocapsule-coated microparticles and a rugged surface for nanosphere-coated microparticles. The decrease in their surface areas was controlled by the nanoparticulated system, which was not dependent on microparticle size. Optical microscopy and X-ray analyses indicated that acid diclofenac crystals were present in formulations prepared with the acid as well as in the nanocapsule-coated microparticles prepared with the salt. The control of coating is dependent on the use of nanocapsules or nanospheres and independent of either the characteristics of the drug or the method of preparing the core.
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spelling Surface morphology of spray-dried nanoparticle-coated microparticles designed as an oral drug delivery systemCoated microparticlesNanoparticlesNanocapsulesSpray dryingX-ray diffractionSEMThis paper was devoted to studying the influence of coating material (nanocapsules or nanospheres), drug model (diclofenac, acid or salt) and method of preparation on the morphological characteristics of nanoparticle-coated microparticles. The cores of microparticles were obtained by spray drying or evaporation and the coating was applied by spray drying. SEM analyses showed nanostructures coating the surface of nanocapsule-coated microparticles and a rugged surface for nanosphere-coated microparticles. The decrease in their surface areas was controlled by the nanoparticulated system, which was not dependent on microparticle size. Optical microscopy and X-ray analyses indicated that acid diclofenac crystals were present in formulations prepared with the acid as well as in the nanocapsule-coated microparticles prepared with the salt. The control of coating is dependent on the use of nanocapsules or nanospheres and independent of either the characteristics of the drug or the method of preparing the core.Brazilian Society of Chemical Engineering2008-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-66322008000200016Brazilian Journal of Chemical Engineering v.25 n.2 2008reponame:Brazilian Journal of Chemical Engineeringinstname:Associação Brasileira de Engenharia Química (ABEQ)instacron:ABEQ10.1590/S0104-66322008000200016info:eu-repo/semantics/openAccessBeck,R. C. R.Lionzo,M. I. Z.Costa,T. M. H.Benvenutti,E. V.Ré,M. I.Gallas,M. R.Pohlmann,A. R.Guterres,S. S.eng2008-07-03T00:00:00Zoai:scielo:S0104-66322008000200016Revistahttps://www.scielo.br/j/bjce/https://old.scielo.br/oai/scielo-oai.phprgiudici@usp.br||rgiudici@usp.br1678-43830104-6632opendoar:2008-07-03T00:00Brazilian Journal of Chemical Engineering - Associação Brasileira de Engenharia Química (ABEQ)false
dc.title.none.fl_str_mv Surface morphology of spray-dried nanoparticle-coated microparticles designed as an oral drug delivery system
title Surface morphology of spray-dried nanoparticle-coated microparticles designed as an oral drug delivery system
spellingShingle Surface morphology of spray-dried nanoparticle-coated microparticles designed as an oral drug delivery system
Beck,R. C. R.
Coated microparticles
Nanoparticles
Nanocapsules
Spray drying
X-ray diffraction
SEM
title_short Surface morphology of spray-dried nanoparticle-coated microparticles designed as an oral drug delivery system
title_full Surface morphology of spray-dried nanoparticle-coated microparticles designed as an oral drug delivery system
title_fullStr Surface morphology of spray-dried nanoparticle-coated microparticles designed as an oral drug delivery system
title_full_unstemmed Surface morphology of spray-dried nanoparticle-coated microparticles designed as an oral drug delivery system
title_sort Surface morphology of spray-dried nanoparticle-coated microparticles designed as an oral drug delivery system
author Beck,R. C. R.
author_facet Beck,R. C. R.
Lionzo,M. I. Z.
Costa,T. M. H.
Benvenutti,E. V.
Ré,M. I.
Gallas,M. R.
Pohlmann,A. R.
Guterres,S. S.
author_role author
author2 Lionzo,M. I. Z.
Costa,T. M. H.
Benvenutti,E. V.
Ré,M. I.
Gallas,M. R.
Pohlmann,A. R.
Guterres,S. S.
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Beck,R. C. R.
Lionzo,M. I. Z.
Costa,T. M. H.
Benvenutti,E. V.
Ré,M. I.
Gallas,M. R.
Pohlmann,A. R.
Guterres,S. S.
dc.subject.por.fl_str_mv Coated microparticles
Nanoparticles
Nanocapsules
Spray drying
X-ray diffraction
SEM
topic Coated microparticles
Nanoparticles
Nanocapsules
Spray drying
X-ray diffraction
SEM
description This paper was devoted to studying the influence of coating material (nanocapsules or nanospheres), drug model (diclofenac, acid or salt) and method of preparation on the morphological characteristics of nanoparticle-coated microparticles. The cores of microparticles were obtained by spray drying or evaporation and the coating was applied by spray drying. SEM analyses showed nanostructures coating the surface of nanocapsule-coated microparticles and a rugged surface for nanosphere-coated microparticles. The decrease in their surface areas was controlled by the nanoparticulated system, which was not dependent on microparticle size. Optical microscopy and X-ray analyses indicated that acid diclofenac crystals were present in formulations prepared with the acid as well as in the nanocapsule-coated microparticles prepared with the salt. The control of coating is dependent on the use of nanocapsules or nanospheres and independent of either the characteristics of the drug or the method of preparing the core.
publishDate 2008
dc.date.none.fl_str_mv 2008-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-66322008000200016
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-66322008000200016
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0104-66322008000200016
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Brazilian Society of Chemical Engineering
publisher.none.fl_str_mv Brazilian Society of Chemical Engineering
dc.source.none.fl_str_mv Brazilian Journal of Chemical Engineering v.25 n.2 2008
reponame:Brazilian Journal of Chemical Engineering
instname:Associação Brasileira de Engenharia Química (ABEQ)
instacron:ABEQ
instname_str Associação Brasileira de Engenharia Química (ABEQ)
instacron_str ABEQ
institution ABEQ
reponame_str Brazilian Journal of Chemical Engineering
collection Brazilian Journal of Chemical Engineering
repository.name.fl_str_mv Brazilian Journal of Chemical Engineering - Associação Brasileira de Engenharia Química (ABEQ)
repository.mail.fl_str_mv rgiudici@usp.br||rgiudici@usp.br
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