A ROBUST COMBINATORIAL APPROACH BASED ON P-GRAPH FOR SUPERSTRUCTURE GENERATION IN DOWNSTREAM BIOPROCESSES
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Chemical Engineering |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-66322015000100259 |
Resumo: | Abstract In the production of chemicals from fermentation, the cost of downstream purification constitutes the major portion of the total production cost. Since the bioprocess generally contains a large amount of biochemical separation units, its flowsheets are complex. How to generate the rigorous superstructure of the downstream bioprocess is a primary problem and key step. In this work, a robust combined approach based on the P-graph was proposed to generate the rigorous superstructure of the downstream process of fermentation. This method integrates the hierarchical decomposition of the heuristics with P-graph-based algorithm MSG with the advantages including: (1) Different design flowsheets could be evaluated simultaneously; (2) An unique bipartite graph, P-graph, was introduced, which could represent the maximum structure clearly and intuitively; (3) The rigorous superstructure could be automatically generated. The validity of the present method was verified with two practical bioprocesses. Results show that the effective processes and the adequate operation units could be determined in the beginning stage of the design, and the tedious reforming steps during process synthesis could be avoided. |
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Brazilian Journal of Chemical Engineering |
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|
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A ROBUST COMBINATORIAL APPROACH BASED ON P-GRAPH FOR SUPERSTRUCTURE GENERATION IN DOWNSTREAM BIOPROCESSESProcess synthesisP-graphRigorous superstructureSeparation network synthesisBioprocessAbstract In the production of chemicals from fermentation, the cost of downstream purification constitutes the major portion of the total production cost. Since the bioprocess generally contains a large amount of biochemical separation units, its flowsheets are complex. How to generate the rigorous superstructure of the downstream bioprocess is a primary problem and key step. In this work, a robust combined approach based on the P-graph was proposed to generate the rigorous superstructure of the downstream process of fermentation. This method integrates the hierarchical decomposition of the heuristics with P-graph-based algorithm MSG with the advantages including: (1) Different design flowsheets could be evaluated simultaneously; (2) An unique bipartite graph, P-graph, was introduced, which could represent the maximum structure clearly and intuitively; (3) The rigorous superstructure could be automatically generated. The validity of the present method was verified with two practical bioprocesses. Results show that the effective processes and the adequate operation units could be determined in the beginning stage of the design, and the tedious reforming steps during process synthesis could be avoided.Brazilian Society of Chemical Engineering2015-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-66322015000100259Brazilian Journal of Chemical Engineering v.32 n.1 2015reponame:Brazilian Journal of Chemical Engineeringinstname:Associação Brasileira de Engenharia Química (ABEQ)instacron:ABEQ10.1590/0104-6632.20150321s00003113info:eu-repo/semantics/openAccessXu,XiaohuiZhu,ChunyingMa,YouguangSong,Haihuaeng2015-05-12T00:00:00Zoai:scielo:S0104-66322015000100259Revistahttps://www.scielo.br/j/bjce/https://old.scielo.br/oai/scielo-oai.phprgiudici@usp.br||rgiudici@usp.br1678-43830104-6632opendoar:2015-05-12T00:00Brazilian Journal of Chemical Engineering - Associação Brasileira de Engenharia Química (ABEQ)false |
dc.title.none.fl_str_mv |
A ROBUST COMBINATORIAL APPROACH BASED ON P-GRAPH FOR SUPERSTRUCTURE GENERATION IN DOWNSTREAM BIOPROCESSES |
title |
A ROBUST COMBINATORIAL APPROACH BASED ON P-GRAPH FOR SUPERSTRUCTURE GENERATION IN DOWNSTREAM BIOPROCESSES |
spellingShingle |
A ROBUST COMBINATORIAL APPROACH BASED ON P-GRAPH FOR SUPERSTRUCTURE GENERATION IN DOWNSTREAM BIOPROCESSES Xu,Xiaohui Process synthesis P-graph Rigorous superstructure Separation network synthesis Bioprocess |
title_short |
A ROBUST COMBINATORIAL APPROACH BASED ON P-GRAPH FOR SUPERSTRUCTURE GENERATION IN DOWNSTREAM BIOPROCESSES |
title_full |
A ROBUST COMBINATORIAL APPROACH BASED ON P-GRAPH FOR SUPERSTRUCTURE GENERATION IN DOWNSTREAM BIOPROCESSES |
title_fullStr |
A ROBUST COMBINATORIAL APPROACH BASED ON P-GRAPH FOR SUPERSTRUCTURE GENERATION IN DOWNSTREAM BIOPROCESSES |
title_full_unstemmed |
A ROBUST COMBINATORIAL APPROACH BASED ON P-GRAPH FOR SUPERSTRUCTURE GENERATION IN DOWNSTREAM BIOPROCESSES |
title_sort |
A ROBUST COMBINATORIAL APPROACH BASED ON P-GRAPH FOR SUPERSTRUCTURE GENERATION IN DOWNSTREAM BIOPROCESSES |
author |
Xu,Xiaohui |
author_facet |
Xu,Xiaohui Zhu,Chunying Ma,Youguang Song,Haihua |
author_role |
author |
author2 |
Zhu,Chunying Ma,Youguang Song,Haihua |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Xu,Xiaohui Zhu,Chunying Ma,Youguang Song,Haihua |
dc.subject.por.fl_str_mv |
Process synthesis P-graph Rigorous superstructure Separation network synthesis Bioprocess |
topic |
Process synthesis P-graph Rigorous superstructure Separation network synthesis Bioprocess |
description |
Abstract In the production of chemicals from fermentation, the cost of downstream purification constitutes the major portion of the total production cost. Since the bioprocess generally contains a large amount of biochemical separation units, its flowsheets are complex. How to generate the rigorous superstructure of the downstream bioprocess is a primary problem and key step. In this work, a robust combined approach based on the P-graph was proposed to generate the rigorous superstructure of the downstream process of fermentation. This method integrates the hierarchical decomposition of the heuristics with P-graph-based algorithm MSG with the advantages including: (1) Different design flowsheets could be evaluated simultaneously; (2) An unique bipartite graph, P-graph, was introduced, which could represent the maximum structure clearly and intuitively; (3) The rigorous superstructure could be automatically generated. The validity of the present method was verified with two practical bioprocesses. Results show that the effective processes and the adequate operation units could be determined in the beginning stage of the design, and the tedious reforming steps during process synthesis could be avoided. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-03-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-66322015000100259 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-66322015000100259 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/0104-6632.20150321s00003113 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Brazilian Society of Chemical Engineering |
publisher.none.fl_str_mv |
Brazilian Society of Chemical Engineering |
dc.source.none.fl_str_mv |
Brazilian Journal of Chemical Engineering v.32 n.1 2015 reponame:Brazilian Journal of Chemical Engineering instname:Associação Brasileira de Engenharia Química (ABEQ) instacron:ABEQ |
instname_str |
Associação Brasileira de Engenharia Química (ABEQ) |
instacron_str |
ABEQ |
institution |
ABEQ |
reponame_str |
Brazilian Journal of Chemical Engineering |
collection |
Brazilian Journal of Chemical Engineering |
repository.name.fl_str_mv |
Brazilian Journal of Chemical Engineering - Associação Brasileira de Engenharia Química (ABEQ) |
repository.mail.fl_str_mv |
rgiudici@usp.br||rgiudici@usp.br |
_version_ |
1754213174673932288 |